Abrus precatorius (Grenn-réglis) : medicinal properties in alcoholic extraction

Anderson JDN et al, Plant growth Inhibitor from Abrus precatorius seeds. Plant Physiol 1972; 49: 1024.

Chang HMT et al, Isolation & structure elucidation of Abrus-lactone A: A new oleanene-type triterpene from the roots & vines of Abrus precatorius L. Chem Commun, 1197–8. 1982-

Jadon A et al, Effects of Abrus precatorius Linn. seed extract on biochemical constituents of male mice. 1984;9(1):100–3.

Chukuo S et al, Potent anti-platelet, anti-inflammatory, & anti-allergic isof lavanquinones from the roots of Abrus precatorius. Plant Medica. 1995;61(4):307-12.

Maiti P et al, Chemical examination of seeds of Abrus precatorius. Jl Indian Acad Forensic Sci.1970;9:64.

Ramnath V et al, Immunopotentiating activity of abrin, a lectin from Abrus precatorius L. Indian Jl of Experiment Biol. 2002; 40(8):910-3.

Kinjo JK et al, A new sapogenol & other constituents in abri semen, the seeds of Abrus precatorius L. Chem Pharm Bull, 39(1): 116–9. 1991-

Sinha R. Post-testicular antifertility effects of Abrus precatorius seed extract in albino rats. Jl Ethnopharmacol, 28(2): 173–81. 1990-Abstract: Oral administration of a 50% ethanol extract of Abrus precatorius seeds (250 mg/kg) in albino rats for 30 & 60 days induced an absolute infertility in males which was reversible. Suppression of sperm motility in the cauda epididymis was the most pronounced effect of the treatment. Such treatment may affect the oxidative/energy metabolism of the cauda epididymis. Histological and histo-cytometric observations in testis & para-reproductive tissues a…

Krupe M et al, Immunitatsforsch allerg klin immunol, studies on the "Mitogenic" effect of hemoglutinating extracts of various plants on the human small lymphocytes in peripheral blood cultured in vitro. 1968; 135(1): 19–42.

Liu CL et al, Primary structure & function analysis of the Abrus precatorius agglutinin A chain by site-directed mutagenesis. Pro(199) Of amphiphilic alpha-Helix H impairs protein synthesis inhibitory activity. Jl Biol Chem, 275(3): 1897–901. 2000-

Nath D et al, Commonly used Indian abortifacient plants with special reference to their teratologic effects in rats. Jl Ethnopharmacol. 1992; 36(2):147–54.

Maiti TK et al, In vitro immunostimulatory properties of Abrus lectins derived peptides in tumor bearing mice. Phytomed. 2009;16:776-78.

Gupta NCB et al, Steroids & Triterpènes from Alangium Lamarckii, Allamanda cathartica, Abrus precatorius & Holoptelea integrifolia. Phytochem; 8: 791–2. 1969-

Misra DS et al. Toxic & haemagglutinating properties of Abrus precatorius. Indian Jl Exp Biol, 4(3): 161-3. 1966-

Tung YC et al, Studies on the chemical components of the seed of Abrus precatorius. Taiwan Il Hsueh Huitsa Chih. 1960;59:868.

Limmatvapirat C et al, Antitubercular & antiplasmodial constituents of Abrus precatorius. Planta Med. 2004;70:276-278.

Reddy S et al, Effects of Abrus precatorius on experimental tumors. Cancer Res, 29: 1447–51. 1969-

Bhaumik H L. Hydrocarbons, fatty acids, triterpenoid & sterols in the seeds of Abrus precatorius. Sci Cult 1987; 53(1): 23–24.

Sethi N et al. Teratological aspects of Abrus precatorius seeds in rats. Fitoterapia. 1990;61(1):61–3.

Wei CH et al, Purification & characterization of two major toxic proteins from the seeds of Abrus precatorius. Jl Biol Chem. 249:3061–7.1974-

Khan AH et al, The nteractions of the erythrocytes of various species with agglutinins of Abrus precatorius. Jl Immunol. 1966;96(3):554-

Hedberg I et al. Inventory of plants used in traditional medicine in Tanzania. Part III. Plants of the families Papilionaceae-Vitaceae. Jl Ethnopharmacol. 1983;9(2/3):237–260.

Ross AI. Abrus precatorius L. Medicinal plants of the World, Chemical Constituents, Trad & Modern Med Uses, 2nd edition. 2010;

Wambebe C et al, Some neuromuscular effects of the crude extracts of the leaves of Abrus precatorius. Jl Ethnopharmacol. 1984; 11(1):49–58.

Tripathi S et al, Immunomodulatory role of native & heat denatured agglutinin from Abrus precatorius. The Inter Jl Biochem Cell boil. 2005;37:451- 62,

Ramaswami K et al, Exploring the Protective Effects of Abrus precatorius in HepG2 & N-Nitroso-diethylamine-induced hepatocellular carcinoma in swiss albino rats. Iran Jl Pharm Sci Spring. 6(2):99-114. 2010-Abstract :

Premanand R et al, Neuroprotective effects of Abrus precatorius Linn. Aerial extract on hypoxic neurotoxicity induced rats. Inter Jl Chem & Pharm Sci.1(1) :2010-

Watt JM et al, the medicinal & poisonous plants of Southern & Eastern Africa. 2nd Ed, E. S. Livingstone, Ltd., London; 1962.

Samad FA et al, Effect of alcohol extract of Ratti seeds (Abrus precatorius) on the reproduction of female rats. Jl Math Sci, 12: 157. 1974-

Zia-Ul-Haque AM et al, Studies on the antifertility properties of active components isolated from the seeds of Abrus precatorius Linn. 1. Pak Jl Zool,15(2): 129–39. 1983-Abstract: Seeds of Abrus precatorius have been used for the isolation & characterization of active components affecting the fertility of the female albino rat. A partially purified fraction (PEP-103) when injected precoitum or postcoitum at dose level of 1 mg/animal, induced 100% sterility, but was ineffective when injected between days 2 & 5 postcoitum. Abridine, a highly purified crystalline component isolated from PEP 10…

Singh S et al, Effect of molluscicidal components of Abrus precatorius, Argemone mexicana & Nerium indicum on certain biochemical parameters of Lymnaea acuminata. Phytother Res, 13(3): 210–3. 1999-Abstract: Exposure to 40% & 80% of the 24 h LC50 of the molluscicidal component of Abrus precatorius (abrin & glycyrrhizin), Argemone mexicana (protopine & sanguinarine) & Nerium indicum (oleandrin) caused a significant decrease in the levels of protein, free amino acid, DNA & RNA in the nervous tissue of Lymnaea acuminata. Except for glycyrrhizin, all the above molluscicides caused a significant …

Ghosal S. et al, Alkaloids of Abrus precatorius. Phytochem, 1971; 10: 195.

Lefar MSD et al, Lipids from the seeds of Abrus precatorius. Jl Pharm Sci 1968; 57: 1442.

Lalithakumari H et al, Purification of proteins from Abrus precatorius & their biological properties. Indian Jl Biochem Biophys.8:321.1971-

Hegde RTK et al, Purification & Characterization of three toxins & two agglutinins from Abrus precatorius seed by using lactamyl-Sepharose affinity chromatography. Anal Biochem,194(1): 101–9. 1991-

Ratnasooriya WD et al,. Sperm antimotility properties of a seed extract of Abrus precatorius. Jl Ethnopharmacol. 133(1/2):85–90, 1991-Abstract : This study examined the inhibitory effects of a methanol extract of Abrus precatorius seeds on the motility of washed human spermatozoa. The extract caused a concentration-related impairment of percentage sperm motility; with the EC50 concentration being 2.29 mg/ml. This effect on motility was essentially irreversible. With the highest concentration tested (20.0 mg/ml), the onset of the antimotility action was almost immediate. In addition, this co…

Zambenedetti P et al, Histochemical localization of glycoconjugates on microglial cells in Alzheimer's disease brain samples by using Abrus precatorius, Maackia amurensis, Momordica charantia, & Sambucus nigra Lectins. Experiment Neurolog.153(1):167–71.1996-Abstract: Four lectins (Abrus precatorius (APA), Maackia amurensis (MAA), Momordica charantia (MCA) & Sambucus nigra (SNA)) have been used to identify glyco-histo-chemically the microglial cells (MGC) activation in autoptic brain samples from Alzheimer's disease (AD) subjects. Three of these lectins (APA, MAA and MCA) have utilized as mi…

Talukder S et al, Evaluation of Fertility Disrupting Potentials of Abrus precatorius Seed Extracts in Male Rats for Arresting Spermatogenesis & Suppressed Fertility In Vivo, Pak Vet Jl, 2013-Abstract: his study was aimed to evaluate the contraceptive potentials of different chemical extracts of Abrus precatorius seeds in male albino rats. The active ingredients of crushed seeds were extracted with 60% aqueous acetone & then partitioned consecutively with n-hexane, ethyl acetate, methanol and water. Water suspended chemical fractions at different doses were administered orally to the male ra…

SINHA N et al, p73 induction by Abrus agglutinin facilitates Snail ubiquitination to inhibit epithelial to mesenchymal transition in oral cancer, Phytomed, 55:179-90, 2019-Abstract: Epithelial-to-mesenchymal transition (EMT), a key step in oral cancer progression, is associated with invasion, metastasis, & therapy resistance, thus targeting the EMT represents a critical therapeutic strategy for the treatment of oral cancer metastasis. Our previous study showed that Abrus agglutinin (AGG), a plant lectin, induces both intrinsic & extrinsic apoptosis to activate the tumor inhibitory mechanism…

Markham KR et al, 8-C-Glucosylscutellarein 6,7-dimethyl ether & its 2″-0-apioside from Abrus precatorius. Phytochem 1989; 28(1): 299–301.

Maiti TK et al, In vitro immunostimulatory properties of Abrus lectins derived peptides in tumor bearing mice. Phytomed.16:776-8. 2009-Abstract: In vitro immunostimulatory effect of Abrus lectins derived peptide fractions (AGP & ABP) was investigated in DL bearing mice. Both AGP & ABP were found to activate splenocytes & induced production of cytokines like IL-2, IFN-gamma & TNF-alpha indicating a Th1 type of immune response. Analysis of in vitro treated splenocytes by flow cytometry revealed an increase in percentage of T & B cell with high expression of activation markers (CD25(+) & CD71(…

Prakesh AO et al, Effect of oral doses of Abrus precatorius Linn. seeds on the oestrus cycle, body weight, uterine weight & cellular structures of uterus in albino rats. 1980;19:286–92.

Choi YH et al, Abrososides AD. Four novel sweet-tasting triterpene glycosides from the leaves of Abrus precatorius. Jl Nat Prod. 1989;52(5):1118–27.

Alagesaboopathie C al, Studies on wound healing activity of red d block coloured seed, white coloured seed extracts of Abrus precatorius L. Inter Jl of Pharma & Bio Sci, ;2(1) :2011-abstract: In the present study deals with the wound healing activity of Red & Black coloured seed, White colour seed of Abrus precatorius L. (Fabaceae). The seed crude extract & methanol insoluble fractions of white form resulted in early wound healing activity in with and without infection. This wound-healing activity due to the presence of gums, mucilages, tannins or phenolic compounds in the seeds. The result…

PANIGRAHI DP et al, Abrus agglutinin inhibits oral carcinogenesis through inactivation of NRF2 signaling pathway, Int JL Macromol, 155:1123, 2020-Abstract: Abrus agglutinin (AGG), a heterotetrametric type II ribosome inactivating protein isolated from the seeds of Abrus precatorius shows potent antitumor activity in different cancer models. We examined the role of antioxidant system in modulation of the anticancer activity of AGG in in vitro & in hamster model of oral cancer. AGG promotes apoptosis through accumulation of ROS in CAL33 cells. Interestingly, our data showed that AGG decreases…

Sarwat J et al. Antifertility effects of ethanolic seed extract of Abrus precatorius l on sperm production & DNA integrity in adult mice, Jl Med Plant Res, 3, 2009, 809-1-Abstract: Abrus precatorius is one of the folk medicinal plants widely used as an antifertility agent in various places of Pakistan. The aim of the present study was to investigate the antifertility activity of A. precatorius seed extract intraperitoneally administered on sperm production & DNA integrity of spermatozoa in adult male albino mice of BALB/c strain. The daily sperm production was measured by counting testicula…

Mensah AY et al: Investigation of the bronchodilator activity of Abrus precatorius. Inter Jl of Pharmaceut Sci Review & Res, 2011; 6 (2): 9–13-Abstract: The methanolic extract of the leaves of Abrus precatorius was evaluated for possible bronchodilator activity by using various in vivo & in vitro models in guinea pigs. Animal studies involved the use of histamine induced broncho-constriction in guinea pigs. These studies showed reduced activity at lower concentration but significant protection at higher doses. The extract offered a maximum degree of protection of 41.62% which was comparable…

Ohba HT et al, Spectroscopic analysis of the cyto-agglutinating activity of abrin-b isolated from Abrus precatorius seeds against leukemic cells. Biosci Biotechnol Biochem, 61(4): 737–739. 1997-Abstract: The cytoagglutinating activity of abrin-b, a toxic lectin isolated from Abrus precatorius seeds, against cultured cell strains derived from acute lymphoblast leukemia (ALL) was investigated by visible (VIS) spectroscopy. Upon addition of abrin-b, the turbidity at 600 nm of cell suspension decreased & this change could be recorded as the cytoagglutination curve. From this curve, the cytoaggl…

Desai VB et al, Studies on the toxicity of Abrus precatorius effect of aqueous extracts of seeds on mitosis & meiosis in grasshopper, (Poecilocera picta). Indian Jl Exp Biol. 1966;4:164.

MUKHOPADHYAY S et al, Abrus agglutinin suppresses human hepatocellular carcinoma in vitro & in vivo by inducing caspase-mediated cell death, Acta Pharmacol Sin, 35(6):814-24, 2014-Abstract: Abrus agglutinin (AGG) from the seeds of Indian medicinal plant AP belongs to the class II ribosome inactivating protein family. In this study we investigated the anticancer effects of AGG against human hepatocellular carcinoma in vitro & in vivo. Methods: Cell proliferation, DNA fragmentation, Annexin V binding, immuno-cyto-fluorescence, Western blotting, caspase activity assays & luciferase assays were…

Rao MV. Anti-fertility effects of alcoholic seeds extract of Abrus precatorius Linn. In male albino rats. Acta Eur Fertil. 18(3):217–20. 1987-Abstract: Effects of alcoholic seed extract of Abrus precatorius Linn. were investigated at a dose of 100 mg/Kg body wt./day/rat for 60 days on fertility, semen profile & sperm metabolism of orally administered sexually mature male albino rats using WHO protocols. Serum testosterone levels were also measured using RIA technique. The data revealed that the cauda epididymal sperm motility was significantly lowered with no effect in its sperm concentrati…

Singh S et al, Effect of molluscicidal components of Abrus precatorius, Argemone mexicana & Nerium indicum on certain biochemical parameters of Lymnaea acuminate. Phytother Res.13(3):210–3.1999-Abstract : Exposure to 40% & 80% of the 24 h LC50 of the molluscicidal component of Abrus precatorius (abrin and glycyrrhizin), Argemone mexicana (protopine & sanguinarine) & Nerium indicum (oleandrin) caused a significant decrease in the levels of protein, free amino acid, DNA and RNA in the nervous tissue of Lymnaea acuminata. Except for glycyrrhizin, all the above molluscicides caused a significan…

Panneerselvam K et al, Crystallization of agglutinin from the seeds of Abrus precatorius. Acta Crystallographica Section D Biol Crystallography. 2000;56(7):898–9.

ABU-Sayed M et al, antifertility studies on ethanolic extract of Abrus precatorius L on swiss male albino mice, Int Jl of Pharmaceut Sci, 3:1, 2012-Abstract: Abrus precatorius is one of the folk medicinal plants widely used as an antifertility agent in various places of south Asian countries including Chittagong region of Bangladesh. The aim of the present study was to investigate the antifertility activity of AP seed extract intraperitonially administered in adult Swiss male albino mice. The intraperitonial administration of 40, 80 & 80 mg/kg body weight of ethanolic seed extract of AP sh…

Nwodo OFC. Elucidation of the nature of some pharmacologically active substances in Abrus precatorius seed, Ph. D thesis, Univ of London, U.K 1981.

Okhale S et al, Abrus precatorius Linn (Fabaceae): phytochemistry, ethnomedicinal uses, ethnopharmacology & pharmacological activities. Inter Jl of Pharmaceut Sci & Res. 2016; 1(6):37-43.

Kafle A et al, A brief review on toxicity of Abrus precatorius in animals, Discovery Sci, 2018-Abstract: Although ornamental for humans, Abrus precatorius is not so when it comes to livestock. Plant bears feather like leaves with active ingredient concentrate in the seed mostly. Poisoning in both humans and animals are common due to the attractive appearance of the seed, shiny red color with black eye at the top. Malicious poisoning in cattle is very frequently encountered; the effected animal shows local signs of poisoning as necrosed lesions on the stabbed site. Crushed seeds when consume…

Okoh SO et al, Antioxidant & free radical scavenging capacity of seed & shell essential oils extracted from Abrus precatorius (L). Antioxidants (Basel) 2014; 3:278-87-Abstract: This study evaluated the antioxidant capacity of seed & shell essential oils of Abrus precatorius (L), a herb used for ethno-medicinal practices in Nigeria. The essential oils were obtained by hydro-distillation. The ability of the oils to act as hydrogen/electrons donor or scavenger of radicals were determined by in-vitro antioxidant assays using 2,2-diphenyl-2-picryl-hydrazyl free radical (DPPH.) scavenging; 2,2′-a…

Njoku UO et al, Immunomodulatory Potential of Alkaloid-Rich Fraction of Abrus precatorius seeds Methanol Extract, Australian Jl of Basic & Applied Sci, 15(6):15-20, 2021-Abstract: The aim of this research was to ascertain the immunomodulatory properties of Abrus precatorius alkaloid-rich seed fraction. METHODS: This study employed the delayed-type hypersensitivity reaction in rats, titer of haemagglutinating antibodies (HA), and in-vivo leukocyte mobilization models. The experimental animals were split into five groups of four. Group 1 received the vehicle, while Groups 2, 3, and 4 received…

Ghosh D et al, Immunomodulatory & anti-tumor activities of native & heat denatured Abrus agglutinin, Immunobiology, 212(2):589-99, 2007-Abstract: Abrus agglutinin (AAG), a hetero tetrameric gal β (1–3) NAc gal specific lectin, is isolated from seeds of Abrus precatorius. In our previous studies we found that the protein could act as an immunomodulator & immunoadjuvant in native (NA) & heat denatured (HDA) conditions. An anticancer effect of the lectin is reported, but its mode of action is not clearly known. In the present study, the anti-tumor activity of AAG (NA, HDA) has been evaluated i…

Behera B et al, Cell penetrating peptides from agglutinin protein of Abrus precatorius facilitate the uptake of Imatinib mesylate, Colloids & surfaces B: Bio interfaces, 140:169-75, 2016-Abstract: Targeted drug delivery is of paramount importance for cancer patients. Cell penetrating peptides (CPPs) have emerged as potent vehicles for this purpose. Herein, we demonstrate CPP- like properties of two peptides: NH2-SGASDDEEIAR-COOH (SR11) & NH2-ICSSHYEPTVRIGGR-COOH (IR15), derived from the tryptic digest of Abrus precatorius agglutinin. Both IR15 & SR11 were found to be non-toxic at lower dose…

Sofi SM et al, Cytotoxic & pro-apoptotic effects of Abrus precatorius L. on human metastatic breast cancer cell line, MDA-MB-231, Cyto-Technol, 2013-Abstract: Abrus precatorius is highly regarded as a universal panacea in the herbal medicine with diverse pharmacological activity spectra. This experimental study on the mechanism of the anticancer activity of A. precatorius leaf extracts, may offer new evidence for AP in the treatment of breast cancer in clinical practice. Cell death was determined by using MTT assay. Further analyses were carried out by doing DNA laddering, PARP cleavage, FA…

Oladimeji AO et al, GC-MS analysis & cytotoxic activity of essential oils from the leaves of Abrus precatorius L. Gaertn, Asian Pac J of Trop Dis, 6’5):372-5, 2016-Abstract: To determine the chemical constituents, cytotoxlic activity & possible applications of the essential oils from the leaves of Abrus precatorius. Methods: Hydro-distillation using Clevenger-type apparatus was employed to obtain the essential oils. Oil analysis was performed using an HP 6890 gas chromatograph coupled with an HP 5973 mass selective detector. The cytotoxicity bioassay was carried out using the brine shrimp l…

Akin-Obasola B et al, Reproduction Control in Coptodon zillii using Abrus precatorius Root Bark Diets as Fertility Inhibitor Agent, Agric & food Sci, 2021-Abstract: The antifertility effects of Abrus precatorius root bark meal (APRB) on Coptodon zillii juvenile was determined by 42 days feeding experiment, with the inclusion levels of 0g, 6g, 12g, 18g and 24g/kg diet. Water volume of 20 litres in a plastic tank (50cm x 27cm x 35 cm dimension) was maintained throughout the period of experiment. Coptodon zilli was fed at 4% body weight. In male fish, testis weight, milt volume, milt count & m…

Modi C et al, immunomodulatory effect of the hydroalcoholic extract of Abrus precatorius L. leaves against cyclophosphamide-induced immunosuppression in mice, Archive of Biol Sci, 73(00):22, 2021-Abstract: This study presents the immunomodulatory potential of Abrus precatorius Linn. (Indian wild licorice) leaves. A hydroalcoholic extract of AP leaves (EAPL) was prepared by maceration. Thirty male mice were divided into five groups as follows: control group, model control group (cyclophosphamide-treated), & three treatment groups (treated with EAPL at doses of 100, 200 and 300 mg/kg, per os,…

Talukder S et al, Investigation into effect of crude mixture of Abrus precatorius seed on hypothalamopituitary gonadal axis & development of antifertility in male rats, Bangladesh Jl Agric Res, 36 (1) (2011),103-9-Abstract: To evaluate the antifertility effect of crude mixture of A. precatorius seeds at the dose level of 50 mg/kg body weight in adult male rats, after oral administration to male rats for 40 days, the rats were sacrificed & hormonal profiles, serum biochemistry, sperm count & histological changes were recorded. A sharp decrease in the serum levels of testosterone (0.70 ± 0.17…

Muthu-Swamy U et al, Anticataractic & antioxidant activities of Abrus precatorius Linn against calcium-induced cataractogenesis using goat lenses, Eur Jl of Experiment Biol, 2(2) :378-84, 2012-ABSTRACT: The present study evaluated the in vitro anticataract & antioxidant activities of ethanolic seed extract of Abrus precatorius Linn. (Fabaceae) against calcium-induced cataractogenesis using goat lenses. Transparent isolated goat lenses were incubated in artificial aqueous humor & divided into seven experimental groups. The extracts at a dose of 100 μg/ml &200 μg/ml were incubated simultaneou…

Gul MZ et al, Antioxidant & antiproliferative activities of Abrus precatorius leaf extracts--an in vitro study, BMC Comp Alter Med, 13, 2013-Abstract: in the present study, A. precatorius leaf extracts were examined for their antioxidant & cytotoxic properties in vitro in order to discover resources for new lead structures or to improve the traditional medicine. Methods: In this study, antioxidant & antiproliferative properties of the different leaf extracts (hexane, ethyl acetate, ethanol & water) from AP were investigated along with the quantification of the polyphenol & flavonoid content…

Nwodo OFC, Botting JH. Uterotonic activity of extracts of the seeds Abrus precatorius seeds. Planta Medica. 1983; 47:230-3.

Taur DJ et al, Antiasthmatic related properties of Abrus precatorius leaves on various models, Jl of Trad & Comp Med, 7(4):428-32, 2017-Abstract: Asthma is a multifaceted inflammatory disorder which results into narrowing of airway with broncho-constriction & spasm. As the complex pathophysiology of asthma, various animal models are generally used to investigate the immunological & physiological pathogenesis of disease. Abrus precatorius Linn (Fabaceae) is a climbing shrub. The leaves & roots are sweet in taste & traditionally used for the treatment of asthma, bronchititis, & inflammation. …

Mensah AY et al: Investigation of the bronchodilator activity of Abrus precatorius. Inter Jl of Pharmaceut Sci Review & Res, 2011; 6 (2): 9–13-Abstract: The methanolic extract of the leaves of Abrus precatorius was evaluated for possible bronchodilator activity by using various in vivo & in vitro models in guinea pigs. Animal studies involved the use of histamine induced broncho-constriction in guinea pigs. These studies showed reduced activity at lower concentration but significant protection at higher doses. The extract offered a maximum degree of protection of 41.62% which was comparable…

UPADHYAY et al, Effect of petroleum ether & ethanol fractions of seeds of Abrus precatorius on androgenic alopecia. Rev. Bras. Farmacogn, 2012, 22(2) :359-63-Abstract: Seeds of Abrus precatorius, are commonly used as purgative, emetic, aphrodisiac & in nervous disorder in traditional and folk medicines. In present study petroleum ether & ethanolic extracts of A. precatorius seeds are evaluated for reversal of androgen (testosterone by i.m route) induced alopecia in male albino Wistar rats and compared to topical administration of standard antiandrogenic drug finasteride for 21 days. The res…

Janaki Raman N et al, Antibacterial Efficacy of Abrus precatorius L. & Asystasia gangetica (L.) T. Anderson, Bentham Sci Pub, 12(2):165-70, 2014--Abstract: The present study was intended to reveal the antibacterial activity of various cold organic solvent extracts of Abrus precatorius L. (Fabaceae) & Asystasia gangetica (L.) T. Anderson (Acanthaceae) against the selected pathogens. Powders of whole plant parts of A. precatorius & A. gangetica were extracted with petroleum ether, benzene, chloroform & ethanol at ambient temperature. The dried extracts were tested for antibacterial activity b…

NAGDA et al, ANTIOXIDANT & ANTIULCER ACTIVITY OF ABRUS PRECATORIUS LEAF EXTRACT AGAINST ACETIC ACID-INDUCED GASTRIC ULCER IN RATS, Asian Jl of Pharmaceut & Clin Research, 2019-Abstract: The present study deals with the study of antiulcer activity of Abrus precatorius leaf extract in acetic acid-induced gastric ulcers was studied in rats. Methods: In the present study, A. precatorius leaf extract was carried out in antiulcer activity against acetic acid-induced gastric ulcer in rats. A. precatorius at doses of 150 mg/kg & 300 mg/kg were administered orally once daily for 10 days. Results: It…

Nwodo OFC et al, Studies on Abrus precatorius seeds II: Antidiarrhoeal activity. Jl of Ethnopharmacol. 1991; 31:395-8,

Verma D et al: Pharmacognostical evaluation & phytochemical standardization of Abrus precatorius L. seeds. Nat Product Sci, 2011; 17(1): 51–7.

Abu S et al, STUDIES ON ETHANOLIC EXTRACT OF ABRUS PRECATORIUS L ON SWISS MALE ALBINO MICE, Semantic Scholars, 2011-Abstract:  The aim of the present study was to investigate the antifertility activity of Abrus precarious seed extract intraperitonially administered in adult Swiss male albino mice. The intraperitonial administration of 40, 80 & 80 mg/kg body weight of ethanolic seed extract of Abrus precatorius shown a highly antifertility activity which done for two months. The lower concentrations (40 mg/kg body weight) of ethanolic seed extract of AP gave temporarily antifertility activit…

SEYI-LADELE A STUDIES ON THE NEUROMUSCULAR EFFECTS OF THE EXTRACTS OF ABRUS PRECATORIUS LINN, Pharmaceut Sci, 2014-Abstract: In order to determine if this plant contributes to paralysis observed in humans at the Univ Nigeria, an investigation was carried out on the neuromuscular effects of the crude water, petroleum ether & ethanol extracts of the seeds, leaves & root of AP Isolated toad's rectus abdominis, rat's phrenic nerve-diaphragm muscle preparation, as well as chicks were used in this study. Isometric contractions of the muscle preparations were recorded by Ugo Basile recording micro…

Bhutia SK et al, Antitumor & proapoptotic effect of Abrusagglutinin derived peptide in Dalton's lymphoma tumor model, Chemico-Biological Interactions, 174(1):11-8, 2008-Abstract: Abrus agglutinin peptide fractions obtained from 10 kD molecular weight cut off membrane permeate (10 kMP), was shown to have selective antiproliferative activity on several tumor cell lines with induction of apoptosis through mitochondrial pathway. The present study was designed to evaluate acute general toxicity & in vivo therapeutic effectiveness of 10 kMPP in Dalton's lymphoma (DL) mice model. The acute toxicit…

Boye A et al, Abrus precatorius Leaf Extract Reverses Alloxan/Nicotinamide-Induced Diabetes Mellitus in Rats through Hormonal (Insulin, GLP-1, & Glucagon) & Enzymatic (α-Amylase/ α-Glucosidase) Modulation, Biomed Res Int, 9920826, 2021-Abstract: Abrus precatorius is used in folk medicine across Afro-Asian regions of the world. Earlier, glucose lowering & pancreato-protective effects of AP leaf extract (APLE) was confirmed experimentally in STZ/nicotinamide-induced diabetic rats; however, the underlying mechanism of antidiabetic effect & pancreato-protection remained unknown. Objective: This…

Olsnes S et al, Studies on the structure & properties of the lectins from Abrus precatorius & Ricinus communis. Biochim Biophys Acta. 405(1):1-10. 1975.-Abstract: The amino acid composition of the isolated A- & B-chains of the toxic lectins Abrin & ricin was determined & compared. Even though the two toxins originate from widely different plants, statistical analysis of the amino acid content indicates extensive homologies in the amino acid sequence of the 4 chains. The intact lectins contain no free SH-groups whereas the isolated A- & B-chains contain close to one free SH-group each. The r…

Nwodo OFC et al, Antisickling effect of Abrus precatorius seed spasmolytic substance. Plant Product Res. 2008; 12:6-9-Abstract: A spasmolytic substance BN, extractable from the seeds of Abrus precatorius has been found to inhibit both metabisulphite- & calcium- induced sickling of human haemoglobin (Hb) SS erythrocytes in vitro. It also inhibited human platelet aggregation elicited by adrenaline (epinephrine) & ADP. In addition, it stabilized Hb SS erythrocyte membrane. The results substantiate the use of the seeds in sickle cell disease,

Hedge et al, Studies on the variants of the protein toxins ricin & Abrin, Eur J Biochem. 204(1):155-64. 1992.-Abstract: This study elucidates some structural & biological features of galactose-binding variants of the cytotoxic protein’s ricin & Abrin. An isolation procedure is reported for ricin variants from Ricinus communis seeds by using lactamtl-Sepharose affinity matrix, similar to that reported previously for variants of Abrin from Abrus precatorius seeds. Ricin variants, sub-fractionated on carboxymethyl-Sepharose CL-6B ion-exchange chromatography, were characterized further by SDS/P…

Kuo SC et al, Potent Antiplatelet, Anti-Inflammatory & Antiallergic Isoflavanquinones from the Roots of Abrus precatorius, Planta Med, 61§4):307-12, 2006-Abstract: Five Isoflavanquinones have been isolated from the roots of Abrus precatorius. Three of them are new & designated as abruquinones D, E, & F. The pharmacological activities of the Isoflavanquinones have been evaluated. The results indicated that abruquinones A, B, & D exhibited remarkable inhibitory effects on the platelet aggregation. The IC50 of abruquinones A & B for the inhibition of the platelet aggregation induced by arachid…

Boye A et al, Glucose lowering & pancreato-protective effects of Abrus Precatorius (L.) leaf extract in normoglycemic & STZ/Nicotinamide - Induced diabetic rats, Jl Ethnopharmacol, 258:112918, 2020-Abstract:  Abrus precatorius (L.) leaves are used as folk medicine by the local communities in the western region of Ghana to treat diabetes mellitus; however, this health claim remains unverified scientifically. Objective: The study investigated glucose lowering & pancreato-protective effects of AP leaf extract (APLE) in normoglycemic & STZ/nicotinamide (NIC)-induced diabetic rats. Method: after…

Rajani A et al, Anthelmintic Activity of Ethanolic Seed Extract of Abrus Precatorius Linn, The Pharma Innov, 1;11, 2013-Abstract: The objective of this work is to evaluate & compare anthelmintic activity of ethanolic extract of red seeds of Abrus precatorius. Earth Worms were used for anthelmintic activity. Albendazole was used as standard drug. Time required for paralysis é death of animals were noted for each sample. AP is a climbing shrub widely distributed in most of the districts of the country in hedges & among bushes on open lands. The objective of this work is to evaluate & compare …

Arora R et al: Phytopharmacological evaluation of ethanolic extract of the seeds of Abrus precatorius Linn. Jl of Pharmacol & Toxicol, 2011; 6 (6): 580–8-Abstract: Abrus precatorius Linn, is a leguminous plant of the Fabaceae family whose stem, bark, leave & roots are widely used for medicinal purposes in tropical & subtropical regions of the world. The plant parts are purgative, emetic, tonic, anti-phlogistic, aphrodisiac & anti-ophthalmic agents. The purpose of the present investigation was to study antioxidant, anti-inflammatory & analgesic activity of A-precatorius, ethanolic seed extra…

SHOKO R et al, Computer-Aided Discovery of Abrus precatorius Compounds with Anti-Schistosomal Potential, Biomed Eng. Comput Biol, 15:11795972241294112. 2024-Abstract: schistosomiasis, which causes over 200 000 deaths annually, has since the 1970s been controlled by praziquantel. The reliance on a single drug to combat schistosomiasis & reports of laboratory resistance to the drug, has created an urgent need in the scientific community to develop new chemotherapies to complement or supplement praziquantel. Medicinal plants are a potential reservoir of compounds with schistosomicidal activity…

Okoko IE et al, Antiovulatory & anti-implantation potential of the methanolic extract of seeds of Abrus precatorius in the rat, Endocrin Pract, 16(4):554-60, 2010-Abstract: To investigate the effect of the methanolic extract of seeds of Abrus precatorius on the estrous cycle, ovulation, & implantation of fetuses in Sprague-Dawley rats. Methods: Cyclic female rats were randomly classified into 4 groups (A through D). Treated rats in group A had daily vaginal smears for a total of 64 consecutive days while being fed A precatorius extract for the first 32 of those days. Treated rats in group B…

Sofi SM et al, Chemopreventive & anti-breast cancer activity of compounds isolated from leaves of Abrus precatorius, 3 Biotech, 8(8):371, 2018-Abstract: The present study focuses on isolation & evaluation of the anti-cancer activity of compounds from the leaves of Abrus precatorius. The bioassay-directed strategy was adopted using chromatographic, gas chromatographic-mass spectrum analysis, nuclear magnetic resonance & X-ray crystallography techniques for purification & characterization of active cytotoxic compounds. Further, MDA-MB-231 breast cancer cell lines & 7,12-dimethylbenz (a) anthr…

Tiwari A et al, Immunomodulatory Activity of the Aqueous Extract of Seeds of Abrus precatorius Linn (Jequirity) in rats, Iranian Jl of Immunol, 7(2):96-103, 2011-Abstract: To study the immunomodulatory functions of the aqueous extract of the seeds of Abrus precatorius commonly known as Indian liquorice, a medicinal plant native to central India. Swiss albino mice were intraperitoneally treated with three doses (0.75, 1.25 & 2.5 µg/kg b.w.) of extract for 7 days. Relative organ weight, delayed type hypersensitivity (DTH) response, haemagglutination titre (HT) & Phagocytic index (PI) were st…

Adedapo AA et al, Studies on the toxicity of an aqueous extract of the leaves of Abrus precatorius in rats, The Onder. Jl of Vet Res, 74(1):31-6, 2007.-Abstract: The toxic effects of an aqueous extract of A precatorius were studied in 20 male white rats over a period of 18 days. The rats were divided into four groups of five rats per group. Those in Group A served as controls while the rats in Groups B, C & D were dosed per os with 400 mg/kg, 800 mg/kg & 1 600 mg/kg of the extract, respectively. Blood samples were collected for haematological & biochemical analysis & specimens of the liver,…

Okokon F et al, Cytoarchitectural Variations in the Ovary, Oviduct & Uterus Following Intra-Gastric Gavages of Abrus precatorius Linn in Albino Rats, Int. Jl. Morpho, 29(4):1408-1413, 2011-Abstract: In developing countries, herbal medicines have continued to remain significant & readily patronized. Numerous plants have been used historically to reduce fertility & modern scientific research has confirmed antifertility effect in some of the herbs tested. To investigate the effects of Abrus precatorius (AP) on the histology of the ovary, oviduct & uterus of female Sprague-Dawley (S-D) rat. A t…

Saganuwan A et al, Haematinic & plasma expander effects of aqueous leaf extract of Abrus precatorius in Mus musculus, Comparative Clinical Pathology, 21(1):1249–55, 2012.-Abstract: Aqueous extract of Abrus precatorius leaf was claimed to have haemopoietic effect. Forty-two mice that weighed 25.76 ± 2.39 g were administered 0.0, 12.5, 25.0, 50.0, 100.0 & 200.0 mg/kg body weight of aqueous extract of AP leaf for a period of 3 weeks. Pretreatment blood sample (0.3 mL) was collected from tail vein of each mouse on day 1 & thereafter on days 7, 14 & 21 of the experimentation for determination of…

Sarwat J et al. Antifertility effects of ethanolic seed extract of Abrus precatorius l on sperm production & DNA integrity in adult mice, Jl Med Plant Res, 3, 2009, 809-1-Abstract: Abrus precatorius is one of the folk medicinal plants widely used as an antifertility agent in various places of Pakistan. The aim of the present study was to investigate the antifertility activity of A. precatorius seed extract intraperitoneally administered on sperm production & DNA integrity of spermatozoa in adult male albino mice of BALB/c strain. The daily sperm production was measured by counting testicula…

Falayi O et al, Nephroprotective properties of the methanol stem extract of Abrus precatorius on gentamicin-induced renal damage in rat, Comp Integr Med, 2019-Abstract: The nephroprotective properties of methanol stem bark extract of AP against gentamicin-induced renal damage in rats was evaluated in this study. Methods: Thirty male Wistar rats were divided into five equal groups. Group A was the negative control group while B was the positive control group which received gentamicin 100 mg/kg intra-peritoneally for 6 days. Group C were pretreated with 100 mg/kg extract for the 3 days & then…