Acalypha indica (Ti-kodenn) : medicinal properties in alcoholic extraction

Sahu-kari R et al, Phytochemical Profile, Free Radical Scavenging & Anti-Inflammatory Properties of Acalypha Indica Root Extract: Evidence from In Vitro & In Vivo Studies, Mol, 26(20):6251, 2021-Abstract: In our in vitro & in vivo studies, we used Acalypha indica root methanolic extract (AIRME), & investigated their free radical scavenging/antioxidant & anti-inflammatory properties. Primarily, phytochemical analysis showed rich content of phenols (70.92 mg of gallic acid/g) & flavonoids (16.01 mg of rutin/g) in AIRME. We then performed HR-LC-MS & GC-MS analyses, & identified 101 & 14 phytoc…

Das AK et al, Diuretic Activity of Acalypha indica. Dhaka Univ J Pharm Sci. 2005; 4:1-2.

KUMARI VK, Evaluation of Antihyperglycemic, Antihyperlipidemic & antioxidant Potential of Ethanolic extract of aerial parts of Acalypha indica Linn in Streptozotocin induced diabetic rats, Shodhganga, 2014-Abstract:

Okorondu S et al, Phytochemical & Antibacterial Properties of Acalypha Hispida Leaves. Int J Nat Appl Sci. 5, 2009.

Hungeling M et al, Cyanogenic & non-cyanogenic pyridone glucosides from Acalypha indica (Euphorbiaceae). Phytochem, 2009; 70: 270-7-Abstract: Seven cyanopyridone derivatives and one corresponding seco compound have been isolated from a methanolic extract of the inflorescences and leaves of Acalypha indica L. (Euphorbiaceae). The absolute configuration of the main cyanogenic glucoside acalypha, (-)-(5R,6S)-5-cyano-5-beta-d-glucopyranosyloxy-6-hydroxy-4-methoxy-1-methyl-2(5,6-dihydro)-pyridone, was deduced from an X-ray crystallographic study. In addition, the 6R-epimer of acalyphin, epiacaly…

Inbaneson SJ et al, In vitro antiplasmodial effect of ethanolic extracts of coastal medicinal plants along Palk Strait against Plasmodium falciparum, Asian Pc J Trop Biomed, 2(5) :365-7, 2012-Of the selected plants species parts, the stem extract of A. indica showed excellent antiplasmodial activity (IC50= 43.81µg/mL) followed by stem extract of J. glandulifera (IC50= 49.14µg/mL). The stem extract of A. aspera, leaf & root extracts of A. indica, leaf, root & seed extracts of J. glandulifera & leaf & stem extracts of P. amarus showed IC50 values between 50 and 100 µg/mL Statistical analysis …

Jebekumar S R D et al, Isolation, identification study of antimicrobial property of a bioactive compound in Indian medicinal plant Acalypha indica (L) Indian nettle. World J of Microbiol & Biotechnol 21: 121-3, (2005).

NANDHAKUMAR M et al, In Vitro Assay of Alpha Amylase Inhibitory Activity of Indian Medicinal Herb Acalypha Indica, J of Chem & Diagnostic Res, 3 :1475-8, 2009.

Rahman MA et al, Analgesic & antiinflammatory activity of methanolic extract of Acalypha indica Linn. Pak J Pharm Sci. 2010;23(3):256-8.

Kumar et al, In vitro Anthelmintic activity of Acalypha indica leaves extracts. Int J Res Ayur Pharm (IJRAP) 2011,2(1) 247-9.

Reddy JS et al, Wound healing effects of Heliotropium indicum, Plumbago Zeylanicum & Acalypha indica in rats. J Ethnopharm, 2002; 79: 249-51.

Ruslan N et al, Evaluation of Acalypha indica extracts for antioxidant. & Antibacterial activities. Universiti Teknologi Malaysia, 2015-

Zahidin NS et al, A review of Acalypha indica L. (Euphorbiaceae) as traditional medicinal plants & its therapeutic potential. Jl Ethnopharmacol 207:146–73 2017-

Solomon RJ et al, Isolation, identification & study of antimicrobial property of a bioactive compound in an Indian medicinal plant Acalypha indica (Indian-nettle). World J Microbiol Biotechnol 21(6):1231–6 2005-

Shivayogi P et al, Postcoital antifertility activity of Acalypha indica L, J of Ethnopharmacol, 1999, 67 (3), 253-8.-Abstract: Four successive solvent extracts of the whole plant Acalypha indica L. (Euphorbiaceae) were tested for postcoital antifertility activity in female albino rats. Of these, the petroleum ether and ethanol extracts were found to be most effective in causing significant antiimplantation activity. The antifertility activity was reversible on withdrawal of the treatment of the extracts. Both the extracts at 600 mg/kg body weight showed estrogenic activity. Histological stu…

Teklani P et al, The important biological activities & phytochemistry of Acalypha indica. Inter Jl of Res in Pharm & Science (1), 2016-

Takle V et al, Pharmacognostic & Phytochemical investigations of aerial parts of Acalypha indica Linn. Pharmacognosy Jl 3(21):33–5, 2011-

Siva K et al, Toxicity of Acalypha indica (Euphorbiaceae) & Achyrantes aspera (Amaranthaceae) leaf extracts to Aedes aegypti (Diptera: Culicidae). J Asia Pacific Entomology 2011; 14: 41-5.

Amarnath K et al, Cytotoxicity induction by ethanolic extract of Acalypha indica loaded casein-chitosan microparticles in human prostate cancer cell line in vitro,  Biomed & Prevent Nut,  4 ,(3), 2014, 445-50-Abstract: The present exploration reports an extensive evaluation of in vitro anticancer efficacy of a novel aqueous ethanolic extract of Acalypha indica (ETAI) loaded chitosan-casein (CS-CT) microparticles in a cancer cell line model. Spherically shaped ETAI loaded CS-CT (CS/CT/ETAI) microparticles were prepared by colloidal coacervation technique in a completely aqueous environment w…

Chekuri S et al, Isolation & anticancer activity of quercetin from Acalypha indica L. against breast cancer cell lines MCF-7 & MDA-MB-231, Biotech, 13(8):289. 2022-Abstract: In this study, the active components of the plant were carefully extracted & identified using three solvent systems. After extraction, we used solvent systems to further purify the main flavonoid chemical constituent. As a result of our analytical strategy, which included HPLC analysis, MS/MS spectroscopic analysis, & NMR data-based constructions, quercetin was determined to be the main chemical constituent. Our study s…

Beena Joy et al, Antioxidant studies & chemical investigation of ethanol extract of Acalypha indica Linn. Drug plants I 2010, 261-79, 34.-Abstract: Acalypha indica Linn of the family Euphorbiaceae, is a common weed growing throughout India & has been used for its medicinal values. Antioxidant potential of A-indica leaf was explored by different in vitro methods. The chemical constituents of the extracts were isolated & identified by spectroscopic analysis. The Antioxidant activity of the extracts was analyzed by evaluating superoxide & hydroxyl radical scavenging activity & effect on lipid …

Chekuri S et al, Phytochemical analysis, anti-oxidant & anti-microbial activity of “Acalypha indica” leaf extracts in different organic solvents. Int JL Phytomed. 2016;8(3):444–52-Abstract Acalypha indica which belongs to Euphorbiaceae family has multiple medicinal properties which include anti-oxidant, anti-bacterial, anti-fungal, anti-inflammatory, antiulcer, anti-helminthic, anti-cancerous, anti-venom, & neuro-protective activity. The present study was designed to evaluate the phytochemical, antimicrobial & anti-oxidant activity of AI leaves extracts in different solvent extractions like…

-CHENGAIAH B et al, IN-VITRO ANTHELMINTIC ACTIVITY OF ROOTS OF ACALYPHA INDICA Linn. Int J of Pharm Tech Res, 1(4):1499-502, 2009.-ABSTRACT: The aim of present study was to evaluate anthelmintic potential of crude alcoholic extract of root of A indica using Pheretima posthuma as test worm. Three concentrations (10, 25 & 50 mg/ml) of alcoholic extract & its various fractions were tested in the bioassay, which involved determination of time paralysis (P) & the time of death (D) of the worms. Albendazole (10 mg/ml) was included as standard reference & distilled water as control. The results pr…

George M et al, Antiarthritic Activity of Plant Acalypha Indica Extract, Am J of Pharmacol & Pharmacother. 2016-Abstract: Acalypha Indica is a species of plant having catkin type of inflorescence. It occurs throughout tropical Africa and South Africa, in India and Sri Lanka, as well as in Yemen and Pakistan.1 This plant is held in high esteem in traditional Tamil Siddha medicine as it is believed to rejuvenate the body. Pharmacological investigation has shown that the plant has potent antibacterial, antifungal, anti-inflammatory, Antiosteoporotic, antioxidant, neuro protective, wound healin…

Ganesh-Kumar et al, Topical application of Acalypha indica accelerates rat cutaneous wound healing by up-regulating the expression of Type I & III collagen. J Ethnopharmacol. 142(1):14-22. 2012-Abstract: The present study investigates the biochemical & molecular rationale behind the healing potential of A-indica on dermal wounds in rats. MATERIAL & METHODS:  A-indica extract (40 mg/kg body weight) was applied topically once a day on full-thickness excision wounds created on rats. The wound tissue was removed & used for estimation of various biochemical & biophysical analyses & to observe hi…

Iniaghe O et al, Proximate Composition & Phytochemical Constituents of Leaves of Some Acalypha Species. Pakistan J Nutr. 8: 256-8, 2009.

Govindarajan M et al, Studies on the effect of Acalypha indica (Euphorbiaceae) leaf extracts on the malarial vector, Anopheles stephensi Liston (Diptera: Culicidae). Parasitol Res 2008; 103: 691-5-Abstract: The leaf extract of Acalypha indica with different solvents viz, benzene, chloroform, ethyl acetate & methanol were tested for larvicidal, ovicidal activity & oviposition attractancy against Anopheles stephensi. The larval mortality was observed after 24 h exposure. The LC50values are 19.25, 27.76, 23.26 & 15.03 ppm, respectively. Mean percent hatchability of the ovicidal activity was ob…

Hazali N et al, SUBCHRONIC TOXICITY OF MALAYSIAN ACALYPHA INDICA: BIOCHEMISTRY AND HAEMATOLOGY ANALYSIS OF RAT, UTM-Jurnal Tèk, 78:5-5, 2012--Abstract: Acalypha indica is one of the medicinal plants that have been used since ages to treat various diseases such as pneumoniae, asthma & skin diseases. This study aimed to explore the subchronic toxicity effect of Acalypha indica on Sprague Dawley rats based on haematological & biochemical parameters. The extract of A indica was prepared by aqueous extraction technique. 48 Sprague Dawley rats aged 7 weeks, weighing 150-200g were randomly divided…

KRISNAMURTI DGB et al, The effect of simvastatin- Acalypha indica Linn. combination on the improvement of fatty pancreas in rats induced with a high fructose & cholesterol diet, J of Vet Anim Res, 9(2):346-50, 2022-Abstract: The study aimed to determine the effect of Acalypha indica Linn. (AI) root extract & a combination of simvastatin-AI on improving the fatty pancreas in Sprague-Dawley rats induced with a high fructose & cholesterol diet. Materials & methods: Twenty-four male Sprague-Dawley rats were induced with a high fructose & cholesterol diet for 4 weeks before being divided into fo…

Muzammil M et al, Anti-inflammatory studies on Acalypha indica L. leaves by membrane stabilization, J of Nat prod & Res,2015-Abstract: The study was designed to evaluate the phytochemical screening & anti-inflammatory activity of methanolic extract of Acalypha indica L. leaves in HRBC membrane stabilization. The methanolic extract showed significant inhibition by using Diclofenac sodium as a standard drug at doses of 125, 250, 500 and 1000 mg/mL & showed a dose dependent inhibition hemolysis of erythrocyte induced by hypotonic solution,

Priya CL et al, Postprandial Antihyperglycemic & Antioxidant Activities of Acalypha indica Linn Stem Extract: An In-vivo Study, Pharmacogn Mag, 12(Suppl) 4: S475-S81, 2016-Abstract: α-glucosidase inhibitors control postprandial hyperglycemia (PPHG) by lowering sharp rise in blood glucose levels after ingestion of carbohydrate rich meal in type 2 diabetic (T2D) individuals. Acalypha indica commonly known as Indian copper leaf is used in traditional medicinal system to treat various diseases. In our previous in-vitro investigation, methanolic extract of AI stems (AIS) proved to be an effectiv…

KRISNAMURTI DGB et al, THE ROLE OF ACALYPHA INDICA LINN. EXTRACT ON HEART RATES WITH MYASTHENIA GRAVIS RAT MODEL, Asian J of Pharmaceut Res, 11:1, 2018.-ABSTRACT: Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ) caused by antibodies that attack components of the postsynaptic membrane, impair neuromuscular transmission, and lead to weakness and fatigue of skeletal muscle. Acetylcholine is also used as a neurotransmitter in the autonomic nervous system. Striated cardiac muscle can be a target for immune attack manifesting as heart failure, arrhythmia, & sudd…

RANJU Garai et al, in vitro anthelmintic activity of Acalypha indica leaves extracts, Int J of Res Ayur & Pharm, 2(1) :247-9, 2011.-ABSTRACT: Ethanol extract from the Acalypha indica leaves of investigated for their anthelmintic activity against Pheretima posthuma.  Three concentrations (1%, 2.5% & 5%) of extract were studied in activity, which involved the determination of time of paralysis & death of the worm. Both the extracts exhibited significant anthelmintic activity at highest concentration of 100 mg/ml.  Piperazine citrate in same concentration as that of extract was included as sta…

MOHAN CS et al, Phytochemical, GC-MS analysis and antibacterial activity of a medicinal plant Acalypha indica, Int J of Pham Tech Res, 4(3) :1050-9, 2012. Abstract: Acalypha indica distributed in the southern part of India particularly in Tamilnadu & it has potential medicinal properties & used as diuretic, anthelmintic and for respiratory problems such as bronchitis, asthma & pneumonia. The present work was designed to investigate the preliminary phytochemical, antibacterial and GCMS analysis of ethanol extract of the plant. Phytochemical screening of leaves extract revealed the presence o…

Kumar VS et al, Mosquito Larvicidal, Oviposition déterrent & Repellent properties of Acalypha indica L extracts against Aedes aegypti, Anopheles stephensi & Culex quinquefasciatus S, Int J Med Biosci. 2012; 1(3): 33 – 41-Abstract: The leaf extract of Acalypha indica with different solvents viz acetone, chloroform, hexane, petroleum ether & ethanol were tested for larvicidal, oviposition deterrent & Repellent activities against the mosquitoes Aedes aegypti, Anopheles stephensi & Culex quinquefasciatus. Larval mortality was observed & recorded after 24 h exposure period. In the present study,…

Leong KX et al, Comparative Studies on a Standardized Subfraction of Red Onion Peel Ethanolic Extract (Plant Substance), Quercetin (Pure Compound), & Their Cell Mechanism & Metabolism on MDA-MB-231. Evid-Based Comp & Alter Med. 2022-Abstract: This study indicates the presence of quercetin in subfraction F1& the standardized value of F1 derived from research using ultra-performance liquid chromatography (UPLC) & AlCl3 colorimetric assays, which further proved that both F1 & quercetin are potential growth inhibitors in MDA-MB-231 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium b…

Manaf AA et al, Antiviral & cytotoxic activities of some plants used in Malaysian indigenous medicine. Pertanika J of Trop Agric Sci, 19 (2/3) :129-36, 1996.-Abstract: Ethanolic extracts of 61 medicinal plants used in Malaysia were screened for antiviral & cytotoxic activities. Antiviral activity was tested against the herpès simplex type-1 (HSV-1) & Vesicular stomatitis (VSV) viruses & cytotoxicity was assayed using the HeLa cell line. Antiviral activity against both viruses was present in the extracts from Calotropis gigantea, Costus speciosus, Eugenia micheli, Hedyotis auricularia, Menth…

RADHIKA SM et al, ANTI DERMATOPHYTIC ACTIVITY OF AZADIRACHTA INDICA & ACALYPHA INDICA LEAVES- AN IN VITRO STUDY, Int J Pharm Bio Sci 2013, 4(4): (P) 618-22-Abstract: This study was conducted to evaluate the effect of ethanolic, ethyl acetate & hexane extracts of Indian medicinal plants Azadirachta indica & Acalypha indica leaves against dermatophytes (60 isolates of Trichophyton rubrum, 22 isolates of Trichophyton mentagrophytes, 9 isolates of Microsporum gypseum & 9 isolates of Trichophyton tonsurans). Of the three extracts used the ethanolic & ethyl acetate extracts were equally good in i…

SATHYA M et al, EFFECT OF ETHANOLIC EXTRACT OF ACALYPHA INDICA LINN. ON ETHYLENE GLYCOL – INDUCED KIDNEY CALCULI IN RATS, Inter J Of Pharm & Pharmaceut Sci, 4 :1, 2012-ABSTRACT. The aim of the present study was to evaluate the Antilithiatic activity of Acalypha indica supplementation on ethylene glycol induced Nephrolithiasis in male Wistar albino rats. Ethylene glycol feeding resulted in decreased the levels of enzymatic and nonenzymatic antioxidants such as glutathione-S-transferase (GST), glucose-6-phosphate dehydrogenase (G-6-PD), glutathione réductase (GR), superoxide dismutase (SOD), …

RAJASEKARAN S et al, ANTI HYPERLIPIDEMIC ACTIVITY OF ACALYPHA INDICA LINN. ON ATHEROGENIC DIET INDUCED HYPERLIPIDEMIA, Int J of Pharma & Pharm, 5: 4, 2013.-Abstract: Acalypha indica Linn. L. (family: Euphorbiaceae) is a weed widely distributed throughout the plains of India. It has been reported to be useful in treating pneumonia, asthma, Rheumatism and several other ailments. As there is no indication of publications regarding the Antihyperlipidemic activity of the plant, the present study was designed to investigate the Anti hyperlipidemic activity of ethanolic, aqueous extracts of Acalyp…

Singh DAP et al, Acaricidal Property of kuppaimemeni (Acalypha indica) against natural Psoroptes cuniculi infestion in broiler Rabbits. Indian J Anim Sci. 2004;74(10):1003-6.-The Acaricidal property of Acalypha indica was evaluated in naturally Psoroptes cuniculi infested broiler rabbits for its in vitro (48 hr) & in vivo (14 days) activity based on livable mite count, lesion score & gross changes. The A indica paste had a lethal effect on the livable mites from 4 hr & maximum inhibition at 48 hr with prominent suppression of lesion. Regrowth of hair in affected areas were prominently seen …

Reddy R et al, ANTI-DIABETIC & HYPO-LIPIDEMIC EFFECT OF ACALYPHA INDICA IN STREPTOZOTOCIN- NICOTINAMIDE INDUCED TYPE-II DIABETIC RATS, Semantic-Scholars, 2012-Abstract: Diabetes mellitus (DM) consists of a group of syndromes characterized by hyperglycemia, altered metabolism of lipids, carbohydrates & proteins. It causes an increased risk of complications from vascular disease. Streptozotocin-Nicotinamide model was used to induce Type-2 diabetes. An ethanolic extract of Acalypha indica was found to lower blood glucose in basal conditions and after heavy glucose load in normal rats. An ethan…

Venkatachalam P et al, Accumulation efficiency, genotoxicity & antioxidant defense mechanisms in medicinal plant Acalypha indica L. under lead stress. Chemosphere 171:544–53 2017-Abstract: The present study was designed to assess the physiological & biochemical changes in roots & shoots of the herb Acalypha indica grown under hydroponic conditions during exposure to lead (Pb) (100–500 mg L⁻¹) for 1–12 d. The accumulation of Pb by AI plants was found to be 121.6 &.5 mg g⁻¹ dry weight (DW) in roots & shoots, respectively, when exposed to a Pb concentration of 500 mg L⁻¹. The presence of Pb io…

Suresh M al, Investigations bioactivity of Acalypha indica (L.), Centella asiatica (L.) & croton bonplandianus (Baill) against multidrug resistant bacteria & cancer cells. Jl of Herbal Med, 28:100359 2021-Abstract: The rate of infections caused by multidrug resistant (MDR) bacteria has recently increased worldwide. Such infections are prevalent in blood cancer patients increasing the risk of disease complications & mortality. This study aimed to investigate the potential of ethnomedicinal plants to inhibit the growth or survival of MDR bacteria & blood cancer cells. A series of major steps …

Zulkifli C et al, Anti-Oxidative Potential of Acalypha indica L. Root Extract on Brain-Derived Neurotrophic Factor Levels in Old Sprague-Dawley Rats In Proceedings of BROMO Conf -1: BROMO, 58-61, 2018, ISBN: 978-989-758-347--Abstract: In 2020, life expectancy in Indonesia is estimated to be greater than 70 years. It implies an increasing number of elderly & becomes a major problem in the health sector. Aging is a process that involves oxidative stress; however, it can be anticipated by the presence of brain-derived neurotrophic factor (BDNF). Objective: The aim of this study is to investiga…

Sanseera D et al, Antioxidant & anticancer activities from aerial parts of Acalypha indica Linn, CHIANG MAÏ Univ J Of Nat Sci, 11(2) :157-68, 2012-Abstract: Extracts of Acalypha indica Linn. (Aerial parts) were investigated for antioxidant activity, anticancer activity, & cytotoxicity. The extracts showed a non-cytotoxic response against Vero cells (African green monkey kidney). The anticancer activity of the extracts was tested using the Resazurin Microplate Assay (REMA). The methanol extract showed anticancer activity against NCI- H187-Small Cell Lung Cancer with an IC50 of 25.00 μgmL-1. …

Sharma D et al, Unveiling the anti-inflammatory potential of Acalypha indica L. & analyzing its research trend: digging deep to learn deep, Schmiedebergs Arch Pharmacol, 397(4):1935-56, 2024-Abstract: The plant Acalypha indica L. is a well-known traditional plant belonging to the family Euphorbiaceae. Traditional practices of the plant claim to treat asthma, pneumonia, wound healing, rheumatoid arthritis, bronchitis, & skin disorders. The major phytochemicals reported are cyanogenic glucosides, tannins, coumarins, flavonoid glycosides, fatty acids, & volatile oils. To summarize the anti-inf…

Shirwaikar A et al, Neutralization potential of Viper russelli (Russell's viper) venom by ethanol leaf extract of Acalypha indica. J Ethnopharm 2004; 94:267-73-The study aims to examine the Viper russelli r, venom neutralization potential of the ethanol leaf extract (250, 500 & 750 mg/kg) of Acalypha indica (Euphorbiaceae). Administration of the ethanol leaf extract at i.p. dose levels of 500 & 750 mg/kg significantly inhibited, in a dose dependent manner, the VR venom-induced lethality, haemorrhage, necrotizing & mast cell degranulation in rats & the cardiotoxic and Neurotoxic effects in i…

Sophia A et al, GC–MS characterization & evaluation of antimicrobial, anticancer & wound healing efficiency of combined ethanolic extract of Tridax procumbens & Acalypha indica. J Mol Struct 1250:131678 2022-Abstract: Two weeding plants namely Tridax procumbens (TP) & Acalypha indica (AI) were studied for their profound wound healing property, antimicrobial activity, & cytotoxicity. The topical formulation is based on the combined ethanolic crude extract of the weeds. The research aims to find the various phytochemicals present in the combinational extract & to evaluate the most abundant ph…

Suresh Reddy J et al, Wound healing effects of Heliotropium indicum, Plumbago Zeylanicum & Acalypha indica in rats, J Ethnopharmacol. 2002; 79: 249-51-Abstract: The ethanolic extracts of Heliotropium indicum, Plumbago zeylanicum & Acalypha indica were evaluated for their wound healing activity in rats. Wound healing activity was studied using excision & incision wound models in rats following topical application. Animals were divided into four groups with six in each group. Ten percent w/v extract of each plant was prepared in saline for topical application. HI possesses better wound healin…

Tilak AH et al, Antibacterial activity of Acalypha indica & Albizzia lebbeck on Pseudomonas aeruginosa –An In vitro study. J Pharm Res 2015,5(1) ,69-71. ABSTRACT: In view of increasing resistance to existing antimicrobial agents, botanicals are being noticed as very important source for discovery of new agents for treating various ailments related to bacterial infections. Acalypha indica and Albizzia lebbeck are known plants in India which possess wide range of pharmacological activities. Butanol, ethanol & methanol leaf extract of A indica & A lebbeck were tested for antibacterial activity…

Yolanda S et al, Acalypha Indica Root Extract Increases Post-Hypoxic Rat Hippocampal Tissue Culture Cell Viability via Phospholipase A2 Inhibition. Med J Indonesia. 2: 136-40, 2013-Abstract: Phospholipase A2 (PLA2) is involved in inflammation & cell death following stroke, & inhibition of its activity may promote neuroregeneration. This study aimed to observe the influence of Acalypha indica Linn root extract towards relative cell viability & PLA2 enzyme level in post-hypoxic hippocampal tissue culture. Methods: Experimental in vitro study using 24 primary neuronal cell cultures obtained fr…

Sanata S et al, Aqueous extract of Acalypha indica leaves for the treatment of Psoriasis: In-vitro studies, Int J of Bioassys, 2017-Abstract: Psoriasis is a chronic inflammatory skin disorder characterized by rapid proliferation of keratinocytes & incomplete keratinization. Discovery of safer & more effective anti-psoriatic drugs remains an area of active research at the present time. A431 & B16-F10 cell lines were used as in vitro models. In the present study, we aimed at assessing the Anti-psoriatic activity of aqueous extract of AI . We analyzed the efficiency of AI leaf extract in induc…

Farida S et al, the combination of Acalypha indica–Centella asiatica extracts decreases the neuronal damage in hypoxia-induced hippocampal injury animal model, Med J Indonesia. 2018; 27:137–44-ABSTRACT: Approximately 80–85% of strokes are ischemic & lead to alterations in neuronal cell morphology & cell death. There is a lack of studies on the effect of the combination of Acalypha indica L. (AI) & Centella asiatica L. (CA) in terms of its neurotherapy property. This study was conducted to investigate the neurotherapeutic effect of the combination of AI–CA extracts in improving rat’s hippoca…

Jayarajan D et al, Efficacy of Carica papaya & Acalypha indica against MDR Acinetobacter species isolated from health-care settings, Dep of Microbiol, 641 029, Tamil Nadu, India, Oral Pres, 2013-Abstract: Acinetobacter spp are ubiquitous aerobic, gram negative, coccobacilli, encapsulated, & non-motile nosocomial pathogen resistance to multiple antimicrobial agents distributed in the environment causing a variety of diseases ranging from Pneumonia to serious meningitis & endocarditis. In recent years, increasing numbers of Hospital acquired infections caused by this genus have been reported.…

Kavitha S et al, In Vitro Antioxidant & Anticancer Studies on the Leaf of Acalypha indica. Biomed Pharmacol J 2009; 2(2)-Abstract: Acalypha indica was found to have antioxidant compounds such as flavonoids & tannins. Hence antioxidant & in vitro anticancer (cytotoxicity) activities were carried out on the leaf extract of A. indica. Aim of this study: to provide an introduction to the principles of drug treatment for solid tumours in cancer treatment. Antioxidant activity was studied by conducting lipid peroxidation assay, the total antioxidant capacity of Et OH & water extracts was found to…

Thaseena BD et al, Evaluating Phytochemical & antidiabetic activity of ethanolic extract of whole Plant of Acalypha indica Linn on alloxan induced diabetic Rats, J of Pharm Res 2011,4(6), 1704-6 Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic complications including retinopathy, angiopathy, nephropathy, neuropathy & causing neurological disorders due to perturbation in utilization of glucose. The present study was designed to investigate the Hypoglycemic properties of ethanolic extract of whole plant of Acalypha indica, w…

Murugan P, Cardioprotective Role of Acalypha Indica Extract on Isoproterenol Induced Myocardial Infarction in Rats. J Pharm Res. 4: 2129-32, 2011-Abstract: Acalypha indica Linn. (Euphorbiaceae) is a common annual shrub that grows in the tropical India & recognized as a medicinal plant in traditional Indian system. The present study is designed to uncover the cardioprotective role of this plant. The A. indica leaves were extracted with water, ethanol & methanol by Soxhlet method. On the basis of qualitative screening of secondary metabolites & antioxidant activity by DPPH method, methanol wa…