Aleurites moluccana (Nwa-Mollik) : medicinal properties in alcoholic extraction

Aleurites moluccana (Nwa-Mollik, Moluccan nut., Noix des Moluques.) — family Euphorbiacées.

Scientific synonyms : Camerium moluccanum (L.) Kuntze, Jatropha moluccana L., Mallotus moluccanus (L.) Müll.Arg. M moluccanus var. genuinus Müll.Arg. Manihot moluccana (L.) Crantz, Rottlera moluccana (L.) Scheff..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 3 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 71 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for colorectal carcinoma

   Plant part used: fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to NEMALA AR (2024)

     Excerpt In an MTT-based cytotoxic assay evaluating anticancer activity, the ethanol extract was tested on colorectal cell lines HCT-116 & primary colon epithelial (PCE) cells. Aleurites moluccanus, commonly referred to as the candlenut or candleberry & also known as the Indian walnut, is a owering tree belonging to the family Euphorbiaceae.

   • According to Maria de Souza M (2021)

     Excerpt The antinociceptive & anti-inflammatory activities of AM bark were evaluated through hyperalgesia induced by carrageenan, PGE, cytokines, bradykinin, epinephrine, Freund’s complete adjuvant, & lipo-poly-saccharide. Aleurites moluccanus is used in folk medicine to treat many diseases including pain & inflammatory processes in general.

   • According to Mendes Hoepers S (2015)

     Excerpt Aleurites moluccana is a medicinal plant popularly used to treat pain, fever, asthma, hepatitis, gastric ulcer & inflammatory process in general. The level of cytokines tumour necrosis factor (TNF) & interleukine-1β (IL-1β) & chemokine keratinocyte chemoattractant (CXCL1/KC), & neutrophil migration were quantified.

   • According to Ayouaz S (2023)

     Excerpt Antioxidant, anti-diabetic, antibacterial, anticancer, gastroprotective, & insecticidal actions are only a few of the biological functions of the AM. Our goal was to transcribe the ethno medicinal usage of Aleurites moluccanus & to highlight the stated pharmacological activity & composition.

   • According to Bresolin TMB (2011)

     Excerpt Seeking to develop a new analgesic phytomedicine, a spray-dried extract (SDE) of Aleurites moluccana (L.) Willd. Similar results were obtained with animals injected with complete Freund's adjuvant (CFA), in which SDE caused inhibition of 48 ± 4%.

2. 2

   Inflammation, wound, incision, injury

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to CESCA TG (2012)

     Excerpt The phytomedicine semisolid was analysed in croton oil-induced ear oedema model in mice, in the healing process, using the excisional wound model in rats, & to prevent mechanical sensitization following plantar incision in rats in the postoperative model of pain. The formulation developed at 0.5 & 1.0% of AM dried extract proved to be effective as an analgesic, anti-inflammatory & wound healing in the pre-clinical studies, which is in agreement with the ethnopharmacological data.

   • According to Mendes Hoepers S (2015)

     Excerpt Aleurites moluccana is a medicinal plant popularly used to treat pain, fever, asthma, hepatitis, gastric ulcer & inflammatory process in general. Recently, pre-clinical studies have demonstrated that the dry extract obtained from AM leaves was effective as analgesic, anti-inflammatory & wound healing.

   • According to Niazi J (2010)

     Excerpt The methanolic extract of dried leaves of AM (AMME) was investigated for anti-inflammatory (carrageenan induced rat paw oedema) & anti-pyretic (brewer's yeast induced pyrexia) activities. Aleurites moluccana (Euphorbiaceae) has been extensively used in folk medicine for the treatment of ulcers, headache, fevers, diarrhea & hypocholesterolemia.

   • According to Maria de Souza M (2021)

     Excerpt Aleurites moluccanus is used in folk medicine to treat many diseases including pain & inflammatory processes in general. Considering the potential of the leaf extract, evidenced in a previous study, the present study investigates the antinociceptive & anti-inflammatory properties of the hydroethanolic extract of AM bark & isolated compounds in animal models of pain.

   • According to HAKIM A (2022)

     Excerpt Since ancient times, the sustained use of Aleurites moluccana in folk medicine has been described verbally & in written manuscripts as a part of local wisdom. Additionally, extracts & secondary metabolites from this species exhibited interesting biological properties, including antibacterial, cytotoxic, anti-inflammatory, & antinociceptive effects.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.