Alysicarpus vaginalis (Common clover) : medicinal properties in alcoholic extraction

Alysicarpus vaginalis (Common clover, Ti-tengn, Small moth, Trèf-kouran, Trèfle courant, Petite teigne) — family Fabacées.

Scientific synonyms : Alysicarpus nummulariifolia-(L)-DC, A nummularifolius sensu auct. A nummularifolius-(L.)-DC., A nummularifolius-(L.)-DC. var. angustatus Ohwi, A vaginalis (L.) DC. var. diversifolius-Chun, A vaginalis-(L.)-DC. var. nummularifolius-Miq., Hedysarum cylindricum-Poir., H vaginale-L.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 4 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 19 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Hepatitis, jaundice, cirrhosis, liver fibrosis

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to WU X (2016)

     Excerpt To study the chemical composition of the Ethanol extract of Alysicarpus vaginalis & the effect of master alkaloid to the hepatic stellate cells (HSC-T6) proliferation. Methods: Using the system of different parts of polar solvent separation method to extract ethyl acetate of A vaginalis & the chemical composition of the ethanol extract were identified.

   • According to Rathi (2015)

     Excerpt Rathi et al, Hepatoprotective activity of ethanolic extract of Alysicarpus vaginalis against nitrobenzene-induced hepatic damage in rats, South Indian J. vaginalis aerial parts in nitrobenzene (NB) induced hepatic injury in Wistar rats.

   • According to Rathi MA (2010)

     Excerpt Alysicarpus vaginalis is a medicinal plant traditionally used by the tribals. vaginalis ethanolic extract of whole plant (AVEE) was evaluated for its nitric oxide radical scavenging activity and reducing power assays using BHT & BHA as standards.

   • According to Author (n.d.)

     Excerpt Brevet CHINA-CN104367612A -Application of Alysicarpus vaginalis extract: The invention discloses an application of an Alysicarpus vaginalis extract in preparation of medicines, foods & healthcare products with a function of protecting liver injuries. A mice test result shows that the A vaginalis extract is capable of obviously lowering CC14 & D-Ga1N & ALT & AST contents of acute liver injury mice serum & obviously improving liver tissue pathological changes caused by CC14 & D-Ga1N, so as to play a protecting role.

   • According to Bashir M (2018)

     Excerpt It has been reported that these species possess analgesic, anti-inflammatory, antimicrobial, antiplasmodial, mosquitocidal, antioxidant, hepatoprotective, larvicidal, antiproliferative & antifertility activity. This article aims to highlight the ethnomedicinal uses, phytochemical a&pharmacological aspects of Alysicarpus species and illustrates the potential of the genus as a source of therapeutic agents.

2. 2

   Bacterial infection: Aeromonas hydrophila, A. caviae, Edwarsiella tarda, Plesiomonas shigelloides, Ralstonia spp., Xanthomonas campestris pv. vesicatoria, Salmonella spp., Shigella spp.

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Rattanata N (2014)

     Excerpt Antibacterial activity against Aeromonas hydrophila, Aeromonas caviae, Edwarsiella tarda, Plesiomonas shigelloides, Ralstonia spp., Xanthomonas campestris pv. Rattanata N et al, Antioxidant & antibacterial properties of selected Thai weed extracts, Asian Pac J of Trop Biomed, 4(11):890-5, 2014,-Objective:To analyze antioxidant & antibacterial properties of selected weeds commonly found in Northeast Thailand including Ageratum conyzoïdes L., Alysicarpus vaginalis L., Commelina benghalensis L., Euphorbia hirta L., Hyptis suaveolens L., Parthenocissus quinquefolia L.

   • According to Bashir M (2018)

     Excerpt It has been reported that these species possess analgesic, anti-inflammatory, antimicrobial, antiplasmodial, mosquitocidal, antioxidant, hepatoprotective, larvicidal, antiproliferative & antifertility activity. This article aims to highlight the ethnomedicinal uses, phytochemical a&pharmacological aspects of Alysicarpus species and illustrates the potential of the genus as a source of therapeutic agents.

   • According to Silva (2015)

     Excerpt This study evaluated in vitro antibacterial activity & their minimum inhibitory concentration of five plants (stem of Stereospermum suaveolens, Oroxylum indicum and roots of Clitoria ternatea, whole plant of Bacopa monnieri & Alysicarpus vaginalis) used in traditional and folk medicine of Sri Lanka for treatment of various bacteria induced infectious diseases. This was performed using aqueous extracts against two gram positive [Staphylococcus aureus (ATCC 25923); Bacillus cereus (ATCC 11778)] & three gram negative [Pseudomonas aeruginosa (ATCC 9027); Escherichia coli (ATCC 35218); & Salmonella typhimurium (ATCC 13311)], clinically important bacterial pathogens, using Kirby-Bauer disk diffusion test and broth micro-dilution technique.

   • According to Tapadiya G (2017)

     Excerpt The methanolic extract of Alysicarpus vaginalis was selected for fractionation due to its known reported biological activity. In antimicrobial activity, the zone of inhibition had been observed in the range of 12-27 mm & MIC value was found in the range of 0.2-0.1 mg/mL.

3. 3

   Cancer: adjuvant treatment for ovarian carcinoma

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Rathi MA (2010)

     Excerpt The Antiproliferative activity of AVEE with cisplatin, anticancer drug was studied using human ovarian cancer cells (PA-1) were measured by MTT assay. vaginalis ethanolic extract of whole plant (AVEE) was evaluated for its nitric oxide radical scavenging activity and reducing power assays using BHT & BHA as standards.

   • According to Mokale SN (2021)

     Excerpt In our previous study Alysicarpus vaginalis has appeared as a promising target for breast cancer hence we have screened potential targets by in silico, In Vitro & In Vivo methods. In addition, the immunoreactivity of ER-α was reduced significantly in MNU-induced mammary carcinoma, which is a key target in ER + breast cancer.

   • According to Sakle NS (2019)

     Excerpt The present study intended to assess the anticancer potential of Alysicarpus vaginalis ethyl acetate fraction (AVEAF) in breast cancer cell lines (MCF-7 & MDA-MB-453) & against N-methyl-N-nitrosourea (MNU) induced mammary carcinoma in Sprague-Dawley rats which resemble the human estrogen dependent breast cancer. Data of the study indicate that AVEAF exhibits In Vitro & In Vivo anticancer activities that associate with its ROS-mediated mitochondrial-mediated intrinsic pathway of apoptosis & necroptosis in MCF-7 cells and may serve as a potential against breast cancer.

   • According to Tapadiya G (2017)

     Excerpt The methanolic extract of Alysicarpus vaginalis was selected for fractionation due to its known reported biological activity. The four fractions were separated & subjected for in vitro antimitotic and anti-proliferative assays along with anti-cancer activity on two human cancers cell lines (SK-MEL-2 and Hep-G2).

   • According to Bashir M (2018)

     Excerpt It has been reported that these species possess analgesic, anti-inflammatory, antimicrobial, antiplasmodial, mosquitocidal, antioxidant, hepatoprotective, larvicidal, antiproliferative & antifertility activity. This article aims to highlight the ethnomedicinal uses, phytochemical a&pharmacological aspects of Alysicarpus species and illustrates the potential of the genus as a source of therapeutic agents.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.