Amaranthus viridis (Creeping spinach) : medicinal properties in alcoholic extraction

Amaranthus viridis (Creeping spinach, Zépina ranpan, Epinard rampant) — family Amaranthacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 18 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 73 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sundarrajan T (2017)

     Excerpt The pharmacological evaluation of ethanol extract of Amaranthus viridis Linn (EEAV) in Aflatoxin B1 (AFB1) induced hepatocellular carcinoma, AFB1 causes oxidative stress & cellular damage its lead to enhanced formation of reactive oxygen spices (ROS) which associated with increases in biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxalacetic acid (SGOT), serum alkaline phosphatase (SALP), ã-glutamate trans peptidase(GGT), bilirubin, lipid levels as well as decrease in the levels of total protein & uric acid. Liver histopathology showed that EEAV reduced the Incidence of liver lesions, lymphocytic infiltrations & hepatic necrosis induced by AFB1 in rats.

   • According to Ashok Kumar BS (2011)

     Excerpt To study heaptoprotective activity of methanolic extract of whole plant of Amaranthus viridis Linn (MeAv) in paracetamol (PCM) induced hepatotoxicity. Materials & Methods: MeAv was screened for hepatoprotective activity in PCM (3 g/kg) induced hepatotoxicity in Wistar rats for 15 days at dose of 200 & 400 mg/kg by measuring liver marker enzymes (serum glutamate pyruvate transaminase & serum glutamate oxaloacetate transaminase), bilirubin (total bilirubin & direct bilirubin) & albumin (ALB), total protein (TP) levels and histopathological studies.

   • According to Umar JK (2015)

     Excerpt The study examined the effect of feeding albino rats with 75% Spiny amaranths leaves with respect to their body weight, liver & kidney indices, haematological & histological response.

   • According to Christopher Larbie (2015)

     Excerpt The aim of this study was to evaluate the phytochemical & total phenolic content, the antioxidant a&anti-proliferative effects of 50% ethanolic extracts of Amaranthus virdis Linn. It can be concluded that the AVL had better antioxidant & anti-proliferative effect & could further be explored as a novel source of cancer therapy.

   • According to House NC (2020)

     Excerpt The study evaluated the phenolic contents, antioxidant, anti-inflammatory & anticancer activities of the methanolic extract of aerial parts from Amaranthus dubius (AD), A. The present study highlights the nutraceuticals potential of Amaranthus species in oxidative damages & cancer proliferation.

2. 2

   Abnormal serum levels: bilirubin, SGOT, SGPT, total protein, uric acid…

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sundarrajan T (2017)

     Excerpt The pharmacological evaluation of ethanol extract of Amaranthus viridis Linn (EEAV) in Aflatoxin B1 (AFB1) induced hepatocellular carcinoma, AFB1 causes oxidative stress & cellular damage its lead to enhanced formation of reactive oxygen spices (ROS) which associated with increases in biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxalacetic acid (SGOT), serum alkaline phosphatase (SALP), ã-glutamate trans peptidase(GGT), bilirubin, lipid levels as well as decrease in the levels of total protein & uric acid. Liver histopathology showed that EEAV reduced the Incidence of liver lesions, lymphocytic infiltrations & hepatic necrosis induced by AFB1 in rats.

   • According to Ashok Kumar BS (2011)

     Excerpt Materials & Methods: MeAv was screened for hepatoprotective activity in PCM (3 g/kg) induced hepatotoxicity in Wistar rats for 15 days at dose of 200 & 400 mg/kg by measuring liver marker enzymes (serum glutamate pyruvate transaminase & serum glutamate oxaloacetate transaminase), bilirubin (total bilirubin & direct bilirubin) & albumin (ALB), total protein (TP) levels and histopathological studies. Results: MeAv significantly (P<0.001) decreases the elevated liver marker enzymes (serum glutamate pyruvate transaminase & serum glutamate oxaloacetate transaminase), bilirubin (total bilirubin & direct bilirubin) & restores albumin (ALB), total protein (TP) levels.

   • According to Umar JK (2015)

     Excerpt The study examined the effect of feeding albino rats with 75% Spiny amaranths leaves with respect to their body weight, liver & kidney indices, haematological & histological response.

   • According to Shamala S (2016)

     Excerpt The supplementation with AV extracts significantly reduced total cholesterol, LDL & triglyceride levels, & increased the levels of HDL & antioxidant enzymes (SOD & GPx). Hypercholesterolemia is one of the main causes for coronary heart disease, which occurs due to high levels of serum cholesterol.

   • According to Uddin S (2016)

     Excerpt Amaranthus viridis is an ecumenical species in the botanical family of Amaranthaceae, which has been traditionally used to treat several skin diseases along with some antilipidemic activities. This plant may contain potential anti-hyperglycemic agents which possibly act through some extra pancreatic mechanism that include glucose uptake by diaphragm & increased glycogenesis by liver.

3. 3

   Diabetic foot

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sahoo BH (2015)

     Excerpt This study aimed to evaluate the wound-healing potential of the ethanolic extract of Amaranthus viridis leaves in diabetic rats. The diabetic animals were divided into fi ve groups, as follows: Group I, which received alloxan treatment only (diabetic control); Group II, which received topical mupirocin ointment (2% w/w) (standard); Groups III, IV, & V, which were treated with ointments prepared from AV extract of 2%, 5%, @ 10% w/w, respectively, daily (test groups) till the wounds completely healed.

   • According to Uddin S (2016)

     Excerpt In vitro glucose uptake by hemi-diaphragm study showed glucose uptake increased significantly in left diaphragm of type 2 diabetes mellitus with insulin alone treated & AV alone treated group, where AV alone treated group showed very highly significance (p=0.000). The present study was carried out to investigate the anti-hyperglycemic effect of 75% ethanolic extract of AV in Neonatal streptozotocin (N-STZ) induced rats’ hemi-diaphragm, including screening for secondary plant metabolites.

   • According to Girija K (2011)

     Excerpt To investigate the anti-diabetic & anti-cholesterolemic activity of methanol extracts of leaves of Amaranthus caudatus, Amaranthus spinosus & Amaranthus viridis in normal & streptozotocin (STZ) induced diabetic rats. Methanol extracts of A caudatus, A spinosus & A viridis showed significant anti-diabetic & anti-cholesterolemic activity, which provides the scientific proof for their traditional claims.

   • According to Krishnamurthy G (2011)

     Excerpt The anti-hyperglycemic & hypolipidemic activity of methanolic extract of leaves of Amaranthus viridis was evaluated by using normal & STZ induced diabetic rats at dose of 200 mg/kg & 400 mg/kg by mouth per day for 21 days. To investigate the antihyperglycemic & hypolipidemic effects of methanolic extract of leaves of Amaranthus viridis (MEAV) in normal & Streptozotocin (STZ) induced diabetic rats.

   • According to Author (2016)

     Excerpt The result has shown that Amaranthus viridis L, a traditional folklore medicinal plant has in vitro antioxidant potentials and hypolipidemic effect which may provide therapeutic potentials in the management of cardiovascular diseases, diabetes & their complications which might be caused by free radical generation & hyperlipidemia.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.