Ananas comosus (Zannanna) : medicinal properties in alcoholic extraction

Ananas comosus (Zannanna, Pineapple, Ananas) — family Broméliacées.

Scientific synonyms : Ananas ananas-(L)-Cockerell, A. Comosus var. variegatus-(Lowe)-M, A. comosus var. sativus-(Schult)-Stelhé, A. porteanus K. Koch, A. stratifolius- hort, A. sativus-Schult, in R&S, Bromelia ananas-L, B. Comosus-L.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 9 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 31 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Xie W (n.d.)

     Excerpt In this study, we investigated hypolipidemic mechanisms of the ethanolic extract of Ananas comosus L. In mice induced by alloxan and high-fat diets, serum total cholesterol remained at a high level (180 - 220 mg/dl) within 7 days of removing high-fat diets but reached normal level (120 - 140 mg/dl) after AC (0.40 g/kg per day) treatment.

   • According to Xie W (2006)

     Excerpt After a sub-acute treatment, AC also could inhibit the development of insulin resistance in high-fat diet-fed and low-dose streptozotocin-treated diabetic rats following the test of loss of tolbutamide-induced blood glucose lowering action. In high-fat diet-fed and low-dose streptozotocin-treated diabetic Wistar rats subjected to challenge with exogenous human insulin, AC treatment at an oral dose of 0.40 g/kg could significantly improve sensitivity to exogenous insulin.

   • According to Xie W (2005)

     Excerpt Hypoglycemic & hypolipidemic activities of the ethanolic extract of A comosus leaves (EEACL) were evaluated in normal & alloxan-induced diabetic rats by oral glucose tolerance test & an olive oïl load test. Antidiabetic, antihyperlipidemic & antioxidative activities of EEACL were also investigated in diabetic-dyslipidemic rats induced by alloxan and a high-fat/high-cholesterol diet.

   • According to Kalpana MB (2014)

     Excerpt Hence, in the present study, an earnest attempt has been made to explore the antidiabetic & antioxidant properties of A comosus leaves in STZ induced diabetic rats. The results of the study indicate that A comosus leaves extract possesses significant antidiabetic activity which in turn is partially due to its antioxidant nature.

2. 2

   Adjuvant treatment for oral carcinoma

   Plant part used: Stem.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to NARITASARI F (2017)

     Excerpt Squamous Carcinoma cell proliferation of human tongue was given a treatment of ethanol extract of Pineapple at three under concentration IC50 values, which are obtained from the sitotoksisitas test, i.e. The purpose of this research is to know the influence of the concentration of ethanol extract of Pineapple at the shoulder of squamous Carcinoma cell apoptosis culture human tongue.

   • According to Bhakti PA (2010)

     Excerpt The aim of the study was to evaluate apoptosis induction by various concentrations of Pineapple-stem ethanolic extract in a human oral tongue cancer cell Supri’s Clone-1 (SP – C1). Conclusion: AC stem ethanolic extract concentration may induce apoptosis of human oral tongue cancer cell (SP – C1).

   • According to Dagsuyu E (2023)

     Excerpt Seeds of Black sesame (Nigella sativa) & flaxseed (Linum usitatissimum), flower of broccoli, (Brassica oleracea var Italica), fruit of lemon, (Citrus lemon) pineapple (Ananas comosus), & pomegranate (Punica granatum); the root of licorice (Glycyrrhiza glabra), & leaves of mistletoe (Viscum album), oleander, (Nerium oleander) stinging nettle (Urtica dioica), tree of heaven (Ailanthus altissima), wormwood (Artemisia absinthium), & white cabbage (Brassica oleracea var capitata) were used.

   • According to Xie W (n.d.)

     Excerpt In this study, we investigated hypolipidemic mechanisms of the ethanolic extract of Ananas comosus L. It is hopeful that AC may serve as the adjuvant for fibrates.

3. 3

   Hypercholesterolaemia, hyperlipidaemia, hypertriglyceridaemia

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Xie W (n.d.)

     Excerpt In this study, we investigated hypolipidemic mechanisms of the ethanolic extract of Ananas comosus L. In mice induced by alloxan and high-fat diets, serum total cholesterol remained at a high level (180 - 220 mg/dl) within 7 days of removing high-fat diets but reached normal level (120 - 140 mg/dl) after AC (0.40 g/kg per day) treatment.

   • According to Xie W (2005)

     Excerpt Hypoglycemic & hypolipidemic activities of the ethanolic extract of A comosus leaves (EEACL) were evaluated in normal & alloxan-induced diabetic rats by oral glucose tolerance test & an olive oïl load test. After 15 days of treatment of diabetic dyslipidemia rats, EEACL significantly decreased blood glucose (-51.0%, P < 0.01), TG (-50.1%, P < 0.01), TC (-23.3%, P < 0.01), LDL-c (-47.9%, P < 0.01) & glycated albumin (-25.4%, P < 0.01) levels, significantly increased serum high-density lipoprotein cholesterol levels (66.2%, P < 0.01) & prevented lower body weight of diabetes (11.8%, P < 0.05), significantly lowered lipid peroxidation productions of blood (-27.8%, P < 0.01), Brain (-31.6%, P < 0.05), liver (-44.5%, P < 0.01) & kidneys (-72.2%, P < 0.05) compared with those in untreated diabetic dyslipidemia rats.

   • According to Author (2012)

     Excerpt Ananas comosus Linn also named Pineapple, has long been one of the most popular of tropical & subtropical fruits which is widely distributed through the world. In high fat diet (HFD) induced hyperlipidemia rats treated with 600mg/kg p.o HAAC showed extreme significant reduction in body weights, TC, TG, LDL, VLDL & blood glucose levels and increased HDL compared to HFD control, whereas animals treated with 400mg/kg p.o HAAC showed significant in body weights & VLDL, very significant reduction in TG, TC & significant increase in HDL compared to HFD control.

   • According to Kalpana MB (2014)

     Excerpt Ananas comosus is one such plant, traditionally used for the treatment of various ailments. The effect of oral administration of A comosus leaves extract (300mg/kg b.w.) on the levels of biochemical parameters were determined in experimental groups of rats.

   • According to Xie W (2006)

     Excerpt Ethanolic extracts of Ananas comosus L. After a sub-acute treatment, AC also could inhibit the development of insulin resistance in high-fat diet-fed and low-dose streptozotocin-treated diabetic rats following the test of loss of tolbutamide-induced blood glucose lowering action.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.