Annona glabra (Mamen) : medicinal properties in alcoholic extraction

Annona glabra (Mamen, Kachiman-Kochon, Mamin, cachiman-à-cochon) — family Annonacées.

Scientific synonyms : Annona palustris-L-(Duss), A. laurifolia-Dunal.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 6 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 28 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for breast and pancreatic carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Liu XX (1999)

     Excerpt Annoglacins A & B were selectively 1000 &10,000 times, respectively, more potent than Adriamycin against the human breast carcinoma (MCF-7) & pancreatic carcinoma (PACA-2) cell lines in our panel of six human solid tumor cell lines. Two new bioactive mono-THF Annonaceous acetogenins, annoglacins A & B, have been isolated from the fractionated ethanolic extracts of the leaves of Annona glabra, directing the fractionation with the brine shrimp lethality test (BST).

   • According to Kumar Sandeep (2013)

     Excerpt Kumar Sandeep et al, Herbal Plants as Potential Anticancer Agents: A Review, Res J of Pharmaceut Biol & Chem Sci, 4 (3):233, 2013-« The results reported by Cochrane et al showed that the total ethanolic extract of Annona glabra seeds induced apoptosis when analyzed by Annexin-V. The Cytotoxicity measurements of Annona glabra leaf, pulp & seed extracts are significantly better than other Anticancer compounds.

   • According to Al-Kazman B (n.d.)

     Excerpt The pharmacological activities of Annona species leaves & seeds include antibacterial, anticancer, antidiabetic & anti-inflammatory properties. The genus of Annona is one of 120 genera of the Annonaceae family & contains more than 119 species of trees & shrubs.

   • According to Anaya-Esparza LM (2020)

     Excerpt Most of their reported health benefits are attributed to the presence of bioactive compounds with various in vitro & in vivo biological activities, such as antidepressant, antidiabetic, neuroprotective, anticonvulsant, anti-inflammatory, antiproliferative, vasorelaxant, antipyretic, anti-ulcer, analgesic, & healing activities. Most species, however, are not marketable & remain underutilized, and are often referred to as wild Annona species, but they are a valuable source of bioactive compounds.

   • According to Dev A (2021)

     Excerpt This review highlights anticancer effects of Annona species in cancer therapy, the efficacy of its bioactive components on diverse cancer types & their mechanism of action and also summarizes the use of these phytochemicals for the purpose of developing a promising anticancer drug candidate in future. It is naturally enriched with a large number of bioactive molecules which attributed to the several biological activities including antioxidant, anti-inflammatory, antimicrobial & anticancer effects.

2. 2

   Neurodegenerative disorders: neonatal neurodegeneration

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ma H (2018)

     Excerpt The present study aimed to investigate the neuroprotective effect of Annona glabra extract (AGE) against ethanol-induced neurodegeneration in neonatal rats. Neonatal rats were assigned to the following groups: group I (normal control rats receiving normal saline), group II (control rats receiving ethanol), & group III (treated rats receiving ethanol-AGE).

   • According to Anaya-Esparza LM (2020)

     Excerpt Most of their reported health benefits are attributed to the presence of bioactive compounds with various in vitro & in vivo biological activities, such as antidepressant, antidiabetic, neuroprotective, anticonvulsant, anti-inflammatory, antiproliferative, vasorelaxant, antipyretic, anti-ulcer, analgesic, & healing activities. Most species, however, are not marketable & remain underutilized, and are often referred to as wild Annona species, but they are a valuable source of bioactive compounds.

3. 3

   Pest control: Phaedonia inclusa Stal

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Prijono D (1993)

     Excerpt Jussieu) seed extracts against Phaedonia inclusa Stal (Coleoptera: Chrysomelidae) was evaluated in laboratory. insecticidal activity of pond-apple (Annona glabra L.) & neem (Azadirachta indica A.

   • According to Basana IR (1994)

     Excerpt Insecticidal activity of aqueous seed extracts of four species of Annona, i.e., A. squamosa exhibited high insecticidal activity against CHC, with LC50s at 2 DAT were 0.051% & 0.208% (% = g seeds/l00 ml I suspension; seed weight was adjusted to 6% moisture content), respectively, & that of A.

   • According to Ma H (2018)

     Excerpt The present study aimed to investigate the neuroprotective effect of Annona glabra extract (AGE) against ethanol-induced neurodegeneration in neonatal rats. Neonatal rats were assigned to the following groups: group I (normal control rats receiving normal saline), group II (control rats receiving ethanol), & group III (treated rats receiving ethanol-AGE).

   • According to Matsumoto S (2014)

     Excerpt A bio-guided optimization of the extraction of bioactive components from Annona glabra leaves has been developed using the etiolated wheat coleoptile bioassay as the control method.

   • According to Priadi T (2021)

     Excerpt glabra contains bioactive substance that is toxic to some organisms, however the effectiveness to control wood degrading termites has not yet been scientifically reported.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.