Artocarpus heterophyllus (Jakié) : medicinal properties in alcoholic extraction

Artocarpus heterophyllus (Jakié, Chatengn-kouli, Jacquier, Coolie chestnut, Châtaigne-à-Coolie) — family Moracées.

Scientific synonyms : Artocarpus integra-Auct. Non-(Thumb)-Merr, A. integrifolia –Auct.mult. Non L.f.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 15 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 75 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Anaemia (associated with diabetes)

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Okonkwo CC (2015)

     Excerpt Anaemia is known to be associated with diabetes; Moreover, with the increasing cases of diabetes there is need for the use of more affordable alternative herbal medicines for the treatment of diabetes & anemia. The aim of this work was to evaluate the hypoglycaemic and haematinic properties of Artocarpus heterophyllus on diabetic rats.

   • According to Ajiboye BO (2020)

     Excerpt This study investigates the in vitro antioxidant potential of polyphenolic-rich extract of A heterophyllus stem bark as well as its antidiabetic activity in streptozotocin-induced diabetic rats. Artocarpus heterophyllus stem bark has been used locally in managing diabetes mellitus with sparse scientific information.

   • According to OSMANI OH (2009)

     Excerpt Artocarpus heterophyllus is a medicinal plant, used by herbalist for treating various diseases, one of which is Diabetes mellitus. This was tested in normal and streptozotocin induced diabetic rats using oral administration of ethanol extracts of A heterophyllus.

   • According to MOOIRA BURCI L (2018)

     Excerpt Ethanolic extract presented zero lethality index and was able to reduce the level of glycemia in females (32.3%) in the subchronic test. Results: A heterophyllus seed presents no toxic effects in brine shrimp, no hemolytic activity, and was effective in cancer cell lines like T47D, TH29 and B16F10.

   • According to Ajiboye BO (2017)

     Excerpt This study sought to investigate the ameliorative effects of ethanol extract Artocarpus heterophyllus in alloxan-induced diabetic rats. The rats were divided into 6 groups, with groups 1 & 2 serving as nondiabetic & diabetic control, respectively; group 3 serving as diabetic rats treated with 5 mg/kg glibenclamide; & groups 4 to 6 were diabetic rats treated with 50, 100, & 150 mg/kg of EAH, respectively.

2. 2

   Type II diabetes mellitus

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ajiboye BO (2020)

     Excerpt This study investigates the in vitro antioxidant potential of polyphenolic-rich extract of A heterophyllus stem bark as well as its antidiabetic activity in streptozotocin-induced diabetic rats. Artocarpus heterophyllus stem bark has been used locally in managing diabetes mellitus with sparse scientific information.

   • According to Ajiboye BO (2017)

     Excerpt This study sought to investigate the ameliorative effects of ethanol extract Artocarpus heterophyllus in alloxan-induced diabetic rats. The rats were divided into 6 groups, with groups 1 & 2 serving as nondiabetic & diabetic control, respectively; group 3 serving as diabetic rats treated with 5 mg/kg glibenclamide; & groups 4 to 6 were diabetic rats treated with 50, 100, & 150 mg/kg of EAH, respectively.

   • According to OSMANI OH (2009)

     Excerpt Artocarpus heterophyllus is a medicinal plant, used by herbalist for treating various diseases, one of which is Diabetes mellitus. This was tested in normal and streptozotocin induced diabetic rats using oral administration of ethanol extracts of A heterophyllus.

   • According to Okonkwo CC (2015)

     Excerpt The aim of this work was to evaluate the hypoglycaemic and haematinic properties of Artocarpus heterophyllus on diabetic rats. heterophyllus increased the haematological indices of diabetic rats.

   • According to MOOIRA BURCI L (2018)

     Excerpt Ethanolic extract presented zero lethality index and was able to reduce the level of glycemia in females (32.3%) in the subchronic test. Results: A heterophyllus seed presents no toxic effects in brine shrimp, no hemolytic activity, and was effective in cancer cell lines like T47D, TH29 and B16F10.

3. 3

   Arthritis, osteoarthritis, rheumatism

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to MEERA M (2017)

     Excerpt The present study was conducted to identify the chemical constituents and evaluate the anti-inflammatory activity of crude ethanolic extracts of spine, skin and rind of jack fruit (Artocarpus heterophyllus) peel. Skin exhibited maximum anti-inflammatory activity, rind had preferential inhibition on Cyclooxygenase-2 and spine & skin inhibited both Cyclooxygenase-1 & 2 in vitro.

   • According to Chukla R (n.d.)

     Excerpt These plants have shown anti-asthmatic, anti-diabetic, anti-inflammatory, anti-microbial, anti-leukemic, anti-mycobacterial, antibacterial, antioxidant, antiulcer, antiviral, anticancer, antimalarial, anti-inflammatory & wound healing properties. The objective of present work was to extract the active constituents a evaluate the wound healing potential of Nerium indicum, Artocarpus heterophyllus, Murraya koenigii, Punica granatum on albino rats using burn wound model.

   • According to Ajiboye BO (2020)

     Excerpt Also, a significant (P < .05) reduction in fasting blood glucose, lipid peroxidation, glucose-6-phosphatase, & all anti-inflammatory parameters were observed in diabetic rats administered the extracts & metformin. The animals were sacrificed on the 28th day of the experiment using the cervical dislocation method; antihyperglycemia & anti-inflammatory parameters were subsequently assessed.

   • According to VIR DK (2016)

     Excerpt Heterophyllus were evaluated against histamine & acetylcholine-induced preconvulsive dyspnea (PCD) in guinea pigs fasted for 24 h were exposed to an atomized fine mist of 2% histamine dihydrochloride aerosol (dissolved in normal saline) using nebulizer at a pressure of 300 mm Hg in the histamine chamber (24 x 14 x 24 cm, made of perplex glass). Heterophyllus Linn leaves (Moraceae), also known as jack fruit (English), is traditionally used to treat asthma.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.