Barleria lupulina (Dog-bite) : medicinal properties in alcoholic extraction

Barleria lupulina (Dog-bite, Thief-stopper, Kwôk-chien, Dog-wood. Thief-stopper, Dog-catcher, Bwa-chien, Baré vôlè, Bois-à-chien. Arrête-voleur, Croc-à-chien, Perro-bwa, No robes, Agua para perros. Detén al ladrón) — family Acanthacées.

Scientific synonyms : Barleria Macrostachya Bojer.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 8 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 59 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for ascites-associated lymphoma

   Plant part used: leaf. Mentioned synergistic association: latex de Calotropis gigantea, Allium cepa-racine.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Choudhury SM (2015)

     Excerpt The present study was aimed to explore the antimitotic activities of Ethanolic (EECGL+EEBLL) & water extracts (WECGL+WEBLL) mixtures of Calotropis gigantea latex & Barleria lupulina leaf of Allium cepa root & in vitro cytotoxic properties in Dalton’s Ascitic Lymphoma (DLA) cell & antiproliferative potency in Dalton’s lymphoma (DLA)-bearing Swiss albino mice. Methods & materials: EECGL+EEBLL & WECGL+WEBLL were subjected to antimitotic study, cell morphology study against Dalton’s Lymphoma Ascites (DLA) cells at the dose level of 100µg/ml.

   • According to Kaewdaungdee S (2025)

     Excerpt In conclusion, Barleria extracts containing barlerin & verbascoside exhibit immunomodulatory properties by activating immune cells to target cancer cells. The findings indicate that two key metabolites, barlerin & verbascoside, are present in all six Barleria extracts, with B.

   • According to Sur PK (2015)

     Excerpt In the pioneering work Sur PK & Ds PK (2012a & b), observed that leaf of Barleria lupulina has anti-clastogenic, anti-tumour, radio-protective & anti-cancer activities in mice a fish.

   • According to Sur PK (2012)

     Excerpt In this study, we have investigated for radio-protection by using Barleria lupulina Lindl. Cancer & tumor formation are a common problem to mankind all over the globe.

   • According to Kumar Das P (2012)

     Excerpt In our previous study, we have reported the radio-protective, anti clastogenic & anti-tumor activities of the leaf extract of Barleria lupulina on mice & fish. Phytochemical analysis, TLC & NMR studies confirm the presence of ursolic acid as the main anti-cancer component, besides other such components, as β sitosterol, sitosterol-3-O-glucoside are also present.

2. 2

   Viremia: Herpes simplex virus (HSV-2)

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to SINGH A (2018)

     Excerpt It is also used as an anti-inflammatory against insect bites, snake bites, herpes simplex virus. Barleria lupulina Lindl.

   • According to Sawarkar HA (2023)

     Excerpt A well-known herb Barleria lupulina is traditionally used as a medicinal & decorative plant. Antibacterial, antiarthritic, CNS depressive, anti-osteoporotic, antioxidant, anti-diabetic, & anti-inflammatory effects are present in isolated components & extract of BL.

   • According to Moin S (2012)

     Excerpt In vitro callus production & antibacterial activity of Barleria lupulina Lindl.

   • According to Wirotesangthong M (2006)

     Excerpt To explore for plants possessing anti-herpes simplex virus type 2 (anti-HSV-2) activity, 80 extracts prepared from 16 medicinal plants collected in Thailand were investigated in vitro using the plaque reduction assay including the inactivation, pre-treatment & post-treatment methods. An ethanol fraction of Barleria lupulina showed the highest SI (781.5) in the inactivation method.

   • According to Suksamrarn S (2003)

     Excerpt When tested for anti-herpes simplex type 1 activity, only compound 3 exhibited antiviral properties. a new iridoid diglucoside, lupulinoside, & eight known iridoid glucosides, acetylbarlerin, ipolamiidoside (3), 6-O-acetylshanzhiside methyl ester, barlerin, shanzhiside methyl ester, mussaenosidic acid, 8-O-acetylshanzhiside, & shanzhiside have been isolated from the flowers of Barleria lupulina.

3. 3

   Bacterial infection: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi, Klebsiella pneumoniae

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kumari R (n.d.)

     Excerpt The ethanolic & aqueous extracts of Barleria lupulina leaves displayed antibacterial activity against five humans bacterial pathogens viz., Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus & Salmonella typhi Klebsiella pneumoniae. lupulina bears a significant amount of phytochemical compounds that pose antibacterial as well as anti-cancerous properties.

   • According to Kumari R (2017)

     Excerpt Results: Methanol soluble leaf extract (MLE) contains more soluble bioactive compounds inhibiting the growth of five bacterial pathogens viz., Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, & Salmonella typhi even at MICs of 1.25 & 2.5 mg/mL. Antibacterial, immunomodulatory & antioxidant properties of aerial parts of Barleria lupulina were investigated in the present communication.

   • According to Kumari R (2016)

     Excerpt The antibacterial activity of acetone, methanol, & water-soluble extracts of both leaf & stem of Barleria lupulina were evaluated against some human pathogens viz., Salmonella typhi, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia & Staphylococcus aureus. aeruginosa, & methanol-soluble leaf (ML) & methanol-soluble stem (MS) extracts against of S typhi.

   • According to Sarmad M (2012)

     Excerpt lupulina essential oil exhibited activity against Bacillus pumilus & Staphylococcus aureus, but was inactive against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, & Streptococcus pyogenes. The chemical composition by gas chromatography mass spectroscopy analysis & antibacterial property of Barleria lupulina essential oil were performed.

   • According to Chomnawang MT (2005)

     Excerpt Among those, Senna alata, Eupatorium odoratum, Garcinia mangostana (GM) & Barleria lupulina had strong inhibitory effects. The MIC values were the same (0.039 mg/ml) for both bacterial species & the MBC values were 0.039 & 0.156 mg/ml against P acnes & S epidermidis, respectively.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.