Cardiospermum halicacabum (Bonè-karé) : medicinal properties in alcoholic extraction

Cardiospermum halicacabum (Bonè-karé, Square cap, Cardiosperme, Heart pea, Marvel pea, Bonnet carré, Pois de cœur, Pois de merveille) — family Sapindacées.

Scientific synonyms : Cardiospermum acuminatum-Miq, C inflatus-Salisb, C corindum-(L)-Medik.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 70 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Veeramani C (2008)

     Excerpt The present study was designed to investigate the antihyperglycaemic effect of ethanolic extract of Cardiospermum halicacabum Linn. The diabetic rats showed an increase in levels of blood glucose & glycosylated haemoglobin (HbA1c) & a decrease in the levels of insulin & haemoglobin (Hb).

   • According to Veeramani C (2012)

     Excerpt To investigate the protective role of Cardiospermum halicacabum leaf extract on glycoprotein metabolism in streptozotocin (STZ)-induced diabetic rats. halicacabum leaf extract (CHE) was administered orally to normal & STZ-diabetic rats for 45 days.

   • According to Stalin C (2013)

     Excerpt The present study was designed to investigate the glucose uptake of (antidiabetic activity) crude n-hexane,ethanol, methanol & aqueous leaf extracts of Cardiospermum Halicacabum. Methods: of Cardiospermum Halicacabumleaf extracts were subjected to inhibitory effect of glucose utilization using specific standard in vitro procedure.

   • According to Veeramani C (2015)

     Excerpt Objective: The present study was aimed to evaluate the effect of C halicacabum leaf extract (CHE) on membrane-bound ATPases in streptozotocin (STZ)-induced diabetic rats. Cardiospermum halicacabum proved to have anti-inflammatory, antihyperglycaemic, antioxidant, antiglycation, analgesic & antipyretic activities.

   • According to Rajeswari R (2014)

     Excerpt Herbal medicines have long been used effectively in the treatment of Diabetes Mellitus. Cardiospermum halicacabum (C.

2. 2

   Liver diseases: cirrhosis, hepatitis, liver fibrosis

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Dinith L (2015)

     Excerpt Treatment with 100 mg/kg & 200 mg/kg body weight of aqueous leaf extract of Cardiospermum halicacabum for 30 days produced a significant dose dependent increase in the sperm counts & sperm motility in both caput & cauda regions. However, the total cholesterol level in the serum remained unchanged & there were no records on renotoxicity; nevertheless, ALE exhibited a hepatoprotective effect.

   • According to Prabakaran S (2014)

     Excerpt Prabakaran S et al, Hepatoprotective Effect of Pisonia alba & Cardiospermum halicacabum in Atrazine Toxicity on LPO & some Antioxidant Activities in the Liver Tissue of Fresh Water Fish Labeo rohita, Inter Jl of Pharmaceut & Biol Archives, 5(2): 174 – 9, 2014;.

   • According to Ara A (2009)

     Excerpt Ara A et al, Hepatoprotective Activity of Cardiospermum halicacabum Stem Extracts Against Carbon tetrachloride-induced Hepatotoxicity in Wistar Rats, Inter Jl of Pharmaceut Sci & Nanotechnology, 2009; 2(1) :487-92.

   • According to Rajesh S (2016)

     Excerpt The objective of the research is to explore the phytoconstituents present in the aqueous, chloroform & methanol extracts of C. To identify the apoptotic effect of leaf extracts against Hep-G2 cell line by Propidium iodide staining method.

   • According to Jeyadevi R (2013)

     Excerpt The hepatoprotective potential of ethanolic extract of Cardiospermum halicacabum (ECH) was evaluated in Wistar rats having liver injury induced by CCl4. Silymarin, a routine hepatoprotective drug was used as reference standard.

3. 3

   Cancer: adjuvant treatment for ascites carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to AISHWARYA V (2014)

     Excerpt To investigate the in vitro antioxidant & anticancer activity of chloroform &ethanol extracts of Cardiospermum halicacabum leaves. showed pronounced anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line than ethanol extract.

   • According to Abdulla SD (2014)

     Excerpt The result revealed that the chloroform extracts showed pronounced anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line than ethanol extract. To investigate the in vitro antioxidant & anticancer activity of chloroform & ethanol extracts of Cardiospermum halicacabum leaves.

   • According to Murugana K (2011)

     Excerpt The medicinal plant Cardiospermum halicacabum, having known anticancer & immunostimulatory activity was explored for their control in this study. halicacabum bioactive principles potentiality as HIV & HBV co-infection controlling novel therapeutics lead compounds.

   • According to Rajesh S (2016)

     Excerpt -Rajeswari R et al, ISOLATION OF ACTIVE COMPOUNDS FROM HYDRO ALCOHOLIC EXTRACT OF CARDIOSPERMUM HALICACABUM LINN, Inter Jl of Pharmaceut Sci & Res,-Abstract : Cardiospermum halicacabum is an herbaceous climber, commonly found throughout India, used as vegetable as well as traditional medicine for rheumatism, lumbago & nervous diseases. The extracts were subjected to preliminary phytochemical analysis; the anticancer activity was evaluated by MTT assay method and GC-MS spectral analysis was carried out for the extract showing best antiproliferative activity.

   • According to Rajesh S (2016)

     Excerpt To investigate the anti-cancer potential of the all three leaf extracts of C.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.