Carica papaya (Papay) : medicinal properties in alcoholic extraction

Carica papaya (Papay, Papaya, Papaye) — family Caricacées.

Scientific synonyms : Papaya carica-Gaertn.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 49 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 201 scientific references for this species (full detail in the application).

Therapeutic indications in alcoholic extraction:

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

Muscle atrophy secondary to type II diabetes

Plant part used: seed.
Scientific references (short excerpts)

Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
- According to Wulansari DD (2019)
  Excerpt This study aims to prove that papaya seed extract has the potential to improve muscle cell atrophy in diabetic conditions. In the diabetic group & the treatment group the dose of 100 mg/kg BW has a smaller area, whereas in the treatment group the dose of 200 & 300 mg/kg BW has an area close to the area of the muscle cell in the normal group.
- According to Ghaffar A (2023)
  Excerpt It has also been revealed that papaya possesses antitrichomonal, antiseptic, antidiabetic, antiinflammatory, & contraceptive properties. Carica papaya has been a popular medicinal as well as nutritious plant for many years.
- According to Haruna M (2022)
  Excerpt This study aims to evaluate the phytochemical, toxicity profile, antidiabetic & antihyperlipidemic effects of ethanolic fruit peel extract of Carica papaya in alloxan-induced diabetic rats. Conclusion: The ethanolic fruit peel extract of CP exhibited potent hypoglycemic & antihyperlipidemic potential in alloxan-induced diabetic rats.
- According to Airaodion A (2019)
  Excerpt This study sought to investigate the antidiabetic effect of ethanolic extract of Carica papaya leaves in alloxan-induced diabetic rats. papaya leaves could replace Glibenclamide in the treatment of diabetes as it has no side effect.
- According to Sasidharan S (1982)
  Excerpt The present study was undertaken to study the antidiabetic effect of the ethanol extracts of Carica papaya and Pandanus amarylfolius on streptozotocin-induced diabetic mice. The results of the present study indicated that there was no significant difference in the body weight of the treated groups when compared to diabetic control.
Type II diabetes mellitus

Plant part used: fruit.
Scientific references (short excerpts)

Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
- According to Haruna M (2022)
  Excerpt This study aims to evaluate the phytochemical, toxicity profile, antidiabetic & antihyperlipidemic effects of ethanolic fruit peel extract of Carica papaya in alloxan-induced diabetic rats. Conclusion: The ethanolic fruit peel extract of CP exhibited potent hypoglycemic & antihyperlipidemic potential in alloxan-induced diabetic rats.
- According to Ghaffar A (2023)
  Excerpt It has also been revealed that papaya possesses antitrichomonal, antiseptic, antidiabetic, antiinflammatory, & contraceptive properties. Carica papaya has been a popular medicinal as well as nutritious plant for many years.
- According to SINGH SP (2020)
  Excerpt Papaya (Carica papaya Linn.) belongs to the family Caricaceae & is well known for its therapeutic & nutritional properties all over the world. Herein, we aimed to review the anticancer, anti-inflammatory, antidiabetic & antiviral activities of papaya leaf.
- According to AKANDA KM (2025)
  Excerpt Plants & their compounds are extensively utilized in various industries, including pharmacy, medicine, food, a& cosmetics, making the papaya (Carica papaya) fruit tree economically vital in tropical & subtropical regions. CP extract is commonly used to treat various health issues, including inflammation & pain, hypertension, diabetes, dermatitis, asthma, & stomach problems due to its rich chemical compositions of flavonoids, steroids, sterol, & β-sitosterol.
- According to Airaodion A (2019)
  Excerpt This study sought to investigate the antidiabetic effect of ethanolic extract of Carica papaya leaves in alloxan-induced diabetic rats. papaya leaves could replace Glibenclamide in the treatment of diabetes as it has no side effect.
High blood pressure, oedema, mild fluid retention

Plant part used: fruit.
Scientific references (short excerpts)

Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
- According to AKANDA KM (2025)
  Excerpt CP extract is commonly used to treat various health issues, including inflammation & pain, hypertension, diabetes, dermatitis, asthma, & stomach problems due to its rich chemical compositions of flavonoids, steroids, sterol, & β-sitosterol. Plants & their compounds are extensively utilized in various industries, including pharmacy, medicine, food, a& cosmetics, making the papaya (Carica papaya) fruit tree economically vital in tropical & subtropical regions.
- According to Akanda MKM (2025)
  Excerpt Papaya extract is commonly used to treat various health issues, including inflammation & pain, hypertension, diabetes, dermatitis, asthma, & stomach problems due to its rich chemical compositions of flavonoids, steroids, sterol, & β-sitosterol. Plants & their compounds are extensively utilized in various industries, including pharmacy, medicine, food, & cosmetics, making the papaya (Carica papaya) fruit tree economically vital in tropical & subtropical regions.
- According to Ghaffar A (2023)
  Excerpt It has also been revealed that papaya possesses antitrichomonal, antiseptic, antidiabetic, antiinflammatory, & contraceptive properties. Carica papaya has been a popular medicinal as well as nutritious plant for many years.
- According to Kong YR (2021)
  Excerpt This review features various studies to provide an overview on how Carica papaya help counteract oxidative stress via various mechanisms of action closely related to its antioxidant properties & eventually improving the management of various oxidative stress-related health conditions. It leads to a range of medical conditions including inflammation, skin aging, impaired wound healing, chronic diseases & cancers but these conditions can be managed properly with the aid of antioxidants.
- According to SINGH SP (2020)
  Excerpt Papaya (Carica papaya Linn.) belongs to the family Caricaceae & is well known for its therapeutic & nutritional properties all over the world. Herein, we aimed to review the anticancer, anti-inflammatory, antidiabetic & antiviral activities of papaya leaf.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.

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Evolution of this plant record

Under the CTA · public change history

Content20 Aug 2026, 08:19 pm

+1 indication · ~5 indications corrected · +1 synergy · +6 references · −4 references

Counts and domains only: indication labels and synergy names are not listed here (open the in-app plant file). Bibliographic texts for new, corrected, or removed references expand below.

+1 indication~5 indications corrected+1 synergy+6 references−4 references

+6 references — show text

Saranya K et al. Herbal plants excellence on dandruff comparatively with commercial hair care products solace to women, Inter Jl for Res Trends & Innov, 4:2, 2019-Abstract: The present study deals with the efficacy of different herbal extracts, shampoos & oils on dandruff causing fungus isolate Malassezia. Isolation of Malassezia was carried out by using Sabouraud dextrose agar (SDA). Different herbal extracts of Phyla nodiflora, Carica papaya, Centratherum punctatum, Indigoflora tinctoria, Capsicum frutescens, Moringa oleifera, commercial shampoos & oils were taken to test the effectivity…

Added

OHOUKO OFJ et al, Diabetes mellitus in ECOWAS: an overview of the safety & efficacy of medicinal plants used in traditional medicine practices, Trop Med Health, 54(1):56. 2026-Abstract: The rich biodiversity of West Africa supports a vast repository of medicinal plants, with traditional medicine playing a central role in managing diseases such as diabetes. Despite their widespread use, the safety a&efficacy of these herbal treatments have not been scientifically explored. This study aims to analyze the traditional uses of antidiabetic plants in Economic Community of West African States coun…

Added

AGFATA FR et al, screening of Carica papaya L. & Psidium guajava Leaves Fraction as Antiviral Drug to Dengue Virus, Teiko med Jl, 44(02):667-75, 2021-Abstract: Up to now, there is no specific antiviral drug to dengue virus (DENV). Medicinal plants have been developing in order to combat DENV infection. The crude extract of Carica papaya L & Psidium guajava leaves showed antiviral activity to DENV in vitro. The aim of this study to screen antiviral activity to DENV among CP & PG leaves fractions. This research is a laboratory experimental study. The study was conducted at the Pharmacology la…

Added

Bengkulu, AFA et al, Formulasi Shampo Ekstrak Biji Pepaya ( Carica Papaya L .), 12(2), 1203–18. 2016-Bengkulu · 2016

Bengkulu, AFA et al, Formulasi Shampo Ekstrak Biji Pepaya ( Carica Papaya L .), 12(2), 1203–18. 2016-

Added

UKHTI W et al, THE UTILIZATION OF PAPAYA SEED EXTRACT (Carica papaya L.) AS ANTI-DANDRUFF SHAMPOO FORMULATION, Pol Neg Sriwijaya, 2021-Abstract: Anti-dandruff shampoo is a shampoo that has active substances that can inhibit the growth of dandruff. Dandruff is the most common problem in the hair, this condition results in the appearance of excessive scales on top of dead skin cells on the scalp. Dandruff is caused by the development of fungi on the scalp that is dirty due to sweat, sebum (oil) glands, & dust. The fungus that develops on the sebaceous glands is Pityrosporum ovale. Papaya seed…

Added

Adetuyi AR et al, Antioxidant & acetylcholinesterase inhibitory activities, in silico analyses, & anti-Alzheimer’s disease potential of leaf extracts of three Nigerian endemic medicinal plants (Spondias mombin, Carica papaya & Kalanchoe crenata), Future Jl of Pharmaceut Sci, 10(6):1-17, 2024-Abstract: The evaluation of the correlations between antioxidant & anti-acetylcholinesterase activities of methanol leaf extracts of three Nigerian endemic plants, Spondias mombin, Carica papaya & Kalanchoe crenata, was carried out. Their constituent phytochemicals were identified by HPLC–DAD fingerprin…

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CP leaves should be added to the list of psychoactive substances that would be catered for in the national drug policyUnknown

CP leaves should be added to the list of psychoactive substances that would be catered for in the national drug policy

Removed

Adequate population mental health promotion should be done at all tiers of the government with the view to sensitize & inform the populace about the psychoactive properties of CP leaves & its use as aUnknown

Removed

Preparation of an Extract from Papaya Leaves: Papaya leaves were left in the air for approximately one to two days under the sun and thus dried, & approximately 27 g, that is, about one dried papaya leaf, was added to 500 ml of water in a glass vessel, brewed for twelve hours, until the total quantity was 50 ml. The brew thus obtained was filter-sterilized to obtain the papaya extract according to the present invention.

Removed

Mental health professionals should update their knowledge in the area of provision of psychological treatments for substance use disorders as CP leaves deserve particular mention in the course of treaUnknown

Removed

By Emmanuel Nossin · ethnopharmacologist

Content25 Jun 2026, 04:51 pm

First public publication

New planttop 3 · ref count

By Emmanuel Nossin · ethnopharmacologist

Carica papaya (Papay) : medicinal properties in alcoholic extraction

Muscle atrophy secondary to type II diabetes

Type II diabetes mellitus

High blood pressure, oedema, mild fluid retention

Evolution of this plant record

+1 indication · ~5 indications corrected · +1 synergy · +6 references · −4 references

First public publication