CHRYSANTHEMUM_DENDROTHEMA INDICUM-(L)-Desmoul. (Chrysanthemum) : medicinal properties in alcoholic extraction

CHRYSANTHEMUM_DENDROTHEMA INDICUM-(L)-Desmoul. (Chrysanthemum, Pyrethrum, Krizantèm, Pirèt, Chrysanthème, Pyrèthre) — family Asteracées.

Scientific synonyms : Acrotis elegans Thunb., Bidens marginata DC., Chrysanthemum indicum L., C japonicum Thunb., C koraiense Nakai, C lushanense Kitam., C nankingense Hand.-Mazz., C procumbens L, C purpureum Pers., C tripartitum S, Collaea procumbens (Rich.) Spreng, Dendranthema indicum (L.) Des Moul., D nankingense (Hand.-Mazz.) P.S.Hsu, Matricaria indica (L.) Desr., Pyrethrum indicum (L.) Cass..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 14 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 107 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of metastatic liver cancer

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Wang, ZD (2010)

     Excerpt Chrysanthemum indicum, one of the medicinal plants or ethnopharmacology, is being used for treatment of many diseases including cancer. Hepatocellular carcinoma (HCC) is an aggressive cancer with a dismal outcome largely due to metastasis & postsurgical recurrence.

   • According to Author (2009)

     Excerpt To investigate the effects of Chrysanthemum indicum extract (CIE) on inhibition of proliferation & on apoptosis, & the underlying mechanisms, in a human hepatocellular carcinoma (HCC) MHCC97H cell line. The cancer-specific selectivity shown in this study suggests that the plant extract could be a promising novel treatment for human cancer.

   • According to YUAN A (2009)

     Excerpt However, the mechanism that account for the inhibitory activity of Chrysanthemum indicum Linné against cancer cells is poorly understood. Chrysanthemum indicum Linné (Asteraceae) is a common Chinese herbal medicine that has been traditionally used for the treatment of inflammation, hypertension & neoplastic diseases in China.

   • According to Choi KT (2016)

     Excerpt -Debnath T et al, ANTIOXIDANT POTENTIAL & OXIDATIVE DNA DAMAGE PREVENTIVE ACTIVITY OF CHRYSANTHEMUM INDICUM EXTRACTS, J of Food Biochem, 2012-Abstract: The objective of this study was to characterize the antioxidant properties of the extracts from Chrysanthemum indicum flower (CIF). Results: Chrysanthemum indicum methanol & water extracts dose dependently inhibited mushroom tyrosinase activity, & the effects of methanol extract were similar to those of kojic acid, a well-known tyrosinase inhibitor.

   • According to Zhang X (2019)

     Excerpt Conclusions: Taken together, our present results suggested that CISCFE treatment could effectively mitigate the D-gal-induced hepatic & cerebral injury, & the underlying mechanism might be tightly related to the decreased oxidative stress, inflammation and apoptosis, indicating CISCFEmight be an alternative & promising agent for the treatment of aging & age-associated brain & liver diseases. Aim of this study: The purpose of the present study was to investigate the protective effect of the supercritical carbon dioxide fluid extract from flowers and buds of CI(CISCFE) on D-galactose-induced brain & liver damage during aging process & to illuminate the underlying mechanisms.

2. 2

   Bacterial and fungal infections: Escherichia coli, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia, Staphylococcus aureus, S. epidermidis, Streptococcus saeruginosa, S. pyogenes, S. sanguinis, S. sobrinus, S. rati, S. gingivalis, Actinobacillus actinomycetemcomitans

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Andogan BC (2002)

     Excerpt Escherichia coli (ATTC 25922), Staphylococcus aureus (ATCC 25923) & Pseudomonas aeruginosa (ATTC 27853 were used as standard test bacterial strains. J exalsa, & C indicum exhibited antibacterial activities against both S aureus & E coli.

   • According to Ratte TA (2023)

     Excerpt The most substantial inhibitory diameter against Staphylococcus aureus was recorded as 19.1±0.8 mm for the JEC3 endophytic fungi, while Escherichia coli exhibited an inhibitory diameter of 16±1.1 mm for the JEC2 endophytic fungi. the objective of this investigation is to discern the classes of secondary metabolites & assess the antibacterial properties of endophytic fungal extracts obtained from Chrysanthemum indicum L.

   • According to Jung E-K (2009)

     Excerpt indicum exhibited stronger antibacterial activity against all oral bacteria tested (MICs, 0.1 to 1.6 mg/ml; MBCs, 0.2 to 3.2 mg/ml) than their major compounds. The chemical components of the essential oil obtained from Chrysanthemum indicum L.

   • According to Lee JH (2011)

     Excerpt Lee JH et al, Evaluation for Antibacterial Effects of Volatile Flavors from Chrysanthemum indicum against Food-Borne Pathogens & Food Spoilage Bacteria.

   • According to Selvaraj Arokiyaraj (2014)

     Excerpt Selvaraj Arokiyaraj et al, Rapid green synthesis of silver nanoparticles from Chrysanthemum indicum L & its antibacterial & cytotoxic effects: an in vitro study Int J Nanomedicine.

3. 3

   Acute and chronic inflammatory skin conditions, dermatitis

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lee Do (2009)

     Excerpt MATERIALS & METHODS: Production of pro-inflammatory cytokines (TNF-α & IL-1β), activation of myeloperoxidase & histological assessment were examinated in acute & chronic skin inflammation; Results: CIE inhibited topical edema in the mouse ear, following administration at 200 mg: kG Ip;) Conclusions: the results demonstrate that CIE is an effective anti-inflammatory agent in murine phorbol ester-induced dermatitis & suggest that the extract may have therapeutic potential in a variety of immune-related cutaneous disease;. Although Chrysanthemum indicum Linné (Compositae) has long been used in traditional Korean, Chinese, Japanese medicine to treat various immune-related diseases the underlying mechanism (s) by which these effects are induced remains to be defined in vivo model system.

   • According to Zhang X (2015)

     Excerpt In this study, the super-critical carbon dioxide extract from flowers & buds of Chrysanthemum indicum Linné (CISCFE), which has been reported to possess free radical scavenging & anti-inflammatory properties, was investigated for its photo-protective effect by topical application on the skin of mice. Furthermore, we observed that CISCFE could obviously decrease UV-induced skin inflammation by inhibiting the production of inflammatory cytokines (interleukin-1β [IL-1β, IL-6, IL-10, tumor necrosis factor-α), alleviate the abnormal changes of anti-oxidative indicators (superoxide dismutase, catalase, & glutathione peroxidase), & down-regulate the levels of MMP-1 & MMP-3.

   • According to Sheela S (2017)

     Excerpt Chrysanthemum indicum is an ancient herbal medicine used as an anti-arthritic, anti-inflammatory & anti-anxiety in many Asian countries. The anxiolytic activities of Ethanolic & Chloroform extracts of CL flowers were evaluated using the elevated plus-maze (EPM) & Open field.

   • According to YOO KY (2016)

     Excerpt In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne (CIL) extract, which has been used as a botanical drug in East Asia, against ischemic damage & to explore the underlying mechanism involving the anti-inflammatory approach. These findings indicate that the pre-treatment of CIL can attenuate neuronal damage/death in the brain after cerebral ischemia/ reperfusion via an anti-inflammatory approach.

   • According to Cheng W (2005)

     Excerpt Chrysanthemum indicum Linné (CI) has a long history for the treatment of inflammation, hypertension & respiratory diseases in China. The above results reveal that CIBF possesses anti-inflammatory, humoral & cellular immunomodulatory & mononuclear phagocytic activities, probably due to the presence of flavonoids.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.