Cicurbita pepo (Courgette) : medicinal properties in alcoholic extraction

Cicurbita pepo (Courgette) — family Cucurbitacées.

Scientific synonyms : Cucurbita aurata-W, C esculenta-N, C fastuosa-S, C melopepo-L, C ovifera-L, C polymorpha-D, Pepo melopepo-(L)-M, P verrucosus-(L)-M, P vulgaris-M.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 60 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for colorectal, liver and ovarian cancer

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ghahremanloo A (2017)

     Excerpt Cucurbita pepo as a favorable plant has different properties notably antioxidant, lipid-lowering & anti-diabetic potential. Results : CP in a dose-dependent manner dramatically decreased triglycerides & low-density lipoprotein, & liver enzymes while high-density lipoprotein was markedly increased in treated groups.

   • According to Nawirska-Olszańska A (2013)

     Excerpt pepo exhibit better antioxidant properties, regardless of the extraction solvent used.

   • According to Iosypenko OO (n.d.)

     Excerpt The qualitative composition and quantitative content of fatty acids in leaves of vegetable marrows (Cucurbita pepo L.

   • According to Bardaa S (2016)

     Excerpt extracted oil from pumpkin seeds (Cucurbita pepo L.) is an interesting target, as it is composed with prominent pharmacological properties to possible wound healing treatments. Conclusions :This study showed the significance of oil fromCP seeds (Cucurbita pepo L.) as a promising drug to healing wounds in animal assays.

   • According to Nkosi CZ (2006)

     Excerpt Nkosi CZ et al, In Vitro Antioxydative activity of pumpkin seed (Cucurbita pepo) protein isolate & its in vivo effect on alanine transaminase & aspartate transaminase in acetaminophen- induced liver injury in low protein fed rats.

2. 2

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Almohaimeed HM (2022)

     Excerpt Conclusion: CP, administrated both topically & orally, can enhance the wound healing process in rats with depressive-like behavior mostly through the antioxidant, anti-inflammatory, & antidepressant activities observed in this study. Wound closure histopathological changes & immunohistochemical expression of CD68, CD3, & CD4 at the wound area was assesse Results: The administration of CP, both orally & topically, significantly reduced (p < 0.001) the depressive-like behavior & corticosterone & pro-inflammatory cytokines levels, while it significantly up-regulated the antioxidant activity compared to the untreated and topically CP-treated groups.

   • According to Almohaimeed HM (2021)

     Excerpt Cucurbita pepo were described to have antioxidant, anti-inflammatory, anti-fatigue, & antidepressant-like effect. Conclusion: CP effectively ameliorated the chronic stress-induced behavioral, biochemical, & adrenal structural changes mostly through its antioxidant & anti-inflammatory effects,.

   • According to Shokrzadeh M (2010)

     Excerpt Also, Solanum nigrum has been used as a diuretic & an antipyretic agent & it has also been used to cure inflammation, edema, mastitis & hepatic cancer. Previous pharmacological tests have shown that it possesses antiviral, anti-inflammatory, & analgesic effects.

   • According to Almohaimeed HM (2021)

     Excerpt Conclusion: Pumpkin ameliorates the depressive-like status induced in rats following exposure to chronic stress through exerting a promising anti-inflammatory, antioxidant & anti-depressant-like effects. The corticosterone, the pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) & interleukin-6 (IL-6), & the oxidant/antioxidant profile were all assessed in the serum.

   • According to Bardaa S (2016)

     Excerpt In fact, morphometric assessment & histological, findings revealed healed biopsies from CP oil treated group of rats, unlike untreated group, and a full re-epithelialization with reappearance of skin appendages and well organized collagen fibers without inflammatory cells. extracted oil from pumpkin seeds (Cucurbita pepo L.) is an interesting target, as it is composed with prominent pharmacological properties to possible wound healing treatments.

3. 3

   Oxidative stress

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Thangavel S (2018)

     Excerpt Conclusion: All the results of the in vitro antioxidant assays revealed potent antioxidant & free radical scavenging activity of the fruit extract of Cucurbita pepo, equivalent to that of standard quercetin & this antioxidant property may be attributed to its high phenolic & flavonoid contents. The present study was carried out to evaluate the in vitro antioxidant properties of hydro alcoholic fruit extract of Cucurbita pepo (HFECP).

   • According to Beshay EVN (2019)

     Excerpt However, PZQ was significantly more effective as an antiparasitic agent, whereas PSO was better in terms of fibrosis & oxidative stress. Moreover, the oxidative stress was evaluated by determining the amounts of malondialdehyde & superoxide dismutase in liver homogenates.

   • According to Ghahremanloo A (2017)

     Excerpt Conclusions :CP ameliorated oxidative stress & dyslipidemia in obese rats, leading to decrease cardiovascular disease risk in obesity,. Cucurbita pepo as a favorable plant has different properties notably antioxidant, lipid-lowering & anti-diabetic potential.

   • According to Nawirska-Olszańska A (2013)

     Excerpt pepo exhibit better antioxidant properties, regardless of the extraction solvent used. The objective of this study was to determine the antioxidant properties, & provide characteristics, of the oil obtained from the seeds of 12 pumpkin varieties belonging to the species Cucurbita maxima Duch.

   • According to Tarhan L (2007)

     Excerpt Tarhan L et al, In Vitro Antioxidant Properties of Cucurbita pepo L.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.