CISSAMPELOS PAREIRA–L (Lyenn-kôd) : medicinal properties in alcoholic extraction

CISSAMPELOS PAREIRA–L (Lyenn-kôd, lyenn-chasè, Rope-vine, Hunter’s vine, Liane-à-corde, liane-à-chasseur) — family Menispermacées.

Scientific synonyms : Cissampelos Pareira var.Haenkera-(CP)-D, C.bojeriana-Miers, C. Capeba-L, C. Cocculus-Poir, C. Mauritiana-Thouars, Dicropetalum mauritiana-Miers.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 18 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 53 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Hepatitis, fatty liver, cirrhosis

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to VERMA KUMAR V (2014)

     Excerpt pareira treated liver samples showed the ability of the CP to prevent hepatocellular necrosis. Cissampelos pareira is a very variable, lofty, slender, dioecious, perennial, climber commonly distributed throughout topical & sub topical India, ascending up to an altitude of c 2,000m.

   • According to Asif M (2021)

     Excerpt pareira hydroalcoholic extract (CPHE) was checked for hepatoprotective activity against CCl4-induced acute & chronic hepatotoxicity. The results indicated that CPHE at 400 mg/kg protected the hepatic cells’ membrane integrity against CCl4-induced hepatotoxicity.

   • According to Surendiran S (2011)

     Excerpt Surendiran S et al, In vitro & In vivo hepatoprotective activity of Cissampelos pareira against carbon tetrachloride induced hepatic damage 2011: 49(12): 939-45.

   • According to Amresh G (2007)

     Excerpt Ethanolic extract of Cissampelos pareira (L.) Hirsuta (Menispermaceae) roots have been examined in various acute and chronic ulcers in validated experimental models in rats. pareira extract of 25–100 mg/kg administered orally, twice daily for 5 days showed a dose-dependent, ulcer-protective effect.

   • According to Amresh G (2007)

     Excerpt Further Cissampelos pareira showed the dose dependent significant protective effect against complete Freund's adjuvant induced arthritis. Lysosomal enzymes (acid phosphatase and N-acetyl glucosaminidase) were decreased by 50% (P < 0.01) and 26.26% (P < 0.05) by using Cissampelos pareira, dexamethasone decreased them 56.56% (P < 0.01) and 31.82% (P < 0.01) and the glycoprotein contents (total hexose and sialic acid) were increased by 1.55-folds (P < 0.01) and 1.51-folds (P < 0.05) by using C pareira while dexamethasone increases them by 1.51-folds (P < 0.001) a&1.60-folds (P < 0.01) respectively in stomach homogenate with respect to arthritic group.

2. 2

   Cancer: adjuvant treatment for gastric carcinoma

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Amresh G (2007)

     Excerpt The objective of the present study was to investigate the protective effect of ethanolic extract of Cissampelos pareira (CPE) against gastric cancer & its mode of action. pareira were studied against Benzo(a)pyrene (B(a)P) induced gastric cancer, tumor multiplicity, micronucleus polychromatic erythrocytes (MnPCEs) in mice.

   • According to Rukachaisisriku T (2021)

     Excerpt Phytochemical investigation of the roots of Cissampelos pareira Linn. Among them, compound 6 showed the highest anti-acetylcholinesterase activity with an IC50 value of 3.26 µM, whereas compound 8 displayed the most potent cytotoxicity against human colon cancer (HT29) cells with an IC50 value of 7.89 µM.

   • According to Author (2021)

     Excerpt The cell lines treated with different quantities of Cissampelos pareira (Cipa). The data set consists of MCF7 which is a human breast cancer cell line with estrogen, progesterone & glucocorticoid receptors.

   • According to Hem-Raj (2019)

     Excerpt The study aimed to evaluate the antiarthritic potential of ethanolic extract of Cissampelos pareira (Menispermaceae) & Stephania glabra (Menispermaceae). Animal models like Freund’s Adjuvant (FA) induced inflammation, Monosodium Iodo Acetate (MIA) induced osteoarthritis and Potassium Oxonate Induced Uricemia (POU) were used for the study.

   • According to Amresh G (2007)

     Excerpt pareira, showed significant antiulcer property (P < 0.05 to P < 0.001) against gastric ulcers in different acute models. pareira significantly enhanced the defense factors as total hexose and sialic acid while significantly reducing the ulcer index in the lipid peroxidase product Malondialdehyde in ethanol-induced ulcers.

3. 3

   Diarrhoea

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Amresh G (2004)

     Excerpt The antidiarrhoeal activity of the ethanolic extract of Cissampelos pareira roots was assessed on experimental animals. The hydroethanolic extract (25-100 mg dry extract kg-1 body mass, p.o.) exhibited a dose dependent decrease in the total number of faecal droppings (control 65, reduced to 26-46) & 29.2-60.0% inhibition in castor oïl-induced diarrhoea.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.