Cissus verticillata (Lyenn-môl) : medicinal properties in alcoholic extraction

Cissus verticillata (Lyenn-môl, Soft vine, Liane molle) — family Vitacéesa.

Scientific synonyms : Cissus argentea-L, C officinalis-K, C ovata-Lam, C sycoides-L, Vitis vitiginea-L.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 6 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 26 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for lymphoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lucena FR (2010)

     Excerpt The hidroalchoolic extract of C sicyoides presented antitumor activity which was prompted by T lymphocytes recruitment to the local lesion & suggests a new pathway to antitumor activity by activation of lymphoid lineage,. The goal of this study was to investigate the cytotoxic a&antitumor activities of C sicyoides hydroalcoholic extract as well as its ability to repair leukocytes cells to injured tissue.

   • According to Kim W (2021)

     Excerpt In the present study, we examined the effects of Cissus verticillata leaf extracts (CVE) against hydrogen peroxide (H2O2) & ischemia-induced neuronal damage in HT22 cells & gerbil hippocampus. CVE treatment reduced the release of interleukin-1β, interleukin-6, & tumor necrosis factor-α 6 h after ischemia.

   • According to Rodriguez-Salazar M (n.d.)

     Excerpt These plants contain several bioactive compounds with high antioxidant activity, such as phenolic compounds, which are compounds that prevent or delay oxidative stress, acting as free radical scavengers (FRSs), & thus reduce the onset of cardiovascular disease, cancer, diabetes, epilepsy, stroke, among other diseases. This chapter will describe the antioxidant & biological activity of Cissus sicyoides & Rosmarinus officinalis leaf extracts, which represent an important natural source of antioxidants.

2. 2

   Diarrhoea

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bezerra FP (2016)

     Excerpt The objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory & antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α₂ adrenergic receptor, muscarinic receptor, nitric oxide (NO) & PGE₂.

3. 3

   Inflammatory conditions: osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bezerra FP (2016)

     Excerpt The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, & the mechanisms of action were analysed by involvement of arachidonic acid (AA) & prostaglandin E₂ (PGE₂). The objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory & antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS).

   • According to Kim W (2021)

     Excerpt In the present study, we examined the effects of Cissus verticillata leaf extracts (CVE) against hydrogen peroxide (H2O2) & ischemia-induced neuronal damage in HT22 cells & gerbil hippocampus. These results suggest that CVE has the potential to reduce the neuronal damage induced by oxidative & ischemic stress by reducing the inflammatory responses & phosphorylation of MAPKs, suggesting that CVE could be a functional food to prevent neuronal damage induced by ischemia.

   • According to Viana GSB (2004)

     Excerpt In the present work, we studied the hypoglycemic & anti-lipemic effects of the aqueous extract prepared from fresh leaves of the plant (AECS), in the model of alloxan-induced diabetes in rats.

   • According to de Sousa Lino C (2007)

     Excerpt The anti-diabetic activity of a fraction from leaves of Cissus verticillata (MSF, methanol soluble fraction), as well as that of tyramine (TYR) were investigated, in the model of alloxan-induced diabetes, in male Wistar rats. Cissus verticillata (syn.

   • According to De Sousa Lino C (2008)

     Excerpt In the present study, the antioxidant activity of methanol soluble fraction (MSF) from Cissus verticillata, used in Brazil & elsewhere as a hypoglycemic & antidiabetic medicinal plant, & tyramine (TYR), one of its main bioactive constituents, was assessed. After 5-day treatments, animals were sacrificed for liver dissection, & determination of anti- oxidant markers such as thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), catalase and nitrite concentrations.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.