Citrus sinensis (Zoranj) : medicinal properties in alcoholic extraction

Citrus sinensis (Zoranj, Orange tree, Oranger) — family Rutacées.

Scientific synonyms : Aurantium sinense-Mill, Citrus aurantium- auct non L, C sinensis-(Mill)-Pers..

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 55 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to DURMUS N (2024)

     Excerpt Citrus peels are rich in bioactive phenolic compounds with various health effects including antioxidant, antiobesity, antiinflammatory, antihypertensive, anti-hypercholesterolemic, antimicrobial, antidiabetic, & anticarcinogenic activities. Citrus peel powder including ascorbic acid & dietary fiber besides phenolics or extracts therefrom can be used as functional food ingredients to extend shelf life & provide health benefits.

   • According to CHENG Y (2024)

     Excerpt It improves liver function, reduces inflammation & oxidative stress, remodels gut microflora, ameliorates hepatocellular necrosis, steatosis, & insulin resistance, & modulates biorhythms. Nobiletin (NOB) is a flavonoid derived from citrus peel that has potential as an alternative treatment for liver disease.

2. 2

   Cancer: adjuvant treatment of liver and breast cancer

   Plant part used: Fruit peel.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to CHENG Y (2024)

     Excerpt It improves liver function, reduces inflammation & oxidative stress, remodels gut microflora, ameliorates hepatocellular necrosis, steatosis, & insulin resistance, & modulates biorhythms. Nobiletin (NOB) is a flavonoid derived from citrus peel that has potential as an alternative treatment for liver disease.

   • According to LIN CY (2022)

     Excerpt The aim of this study was to explore the lipid-lowering effects of nobiletin & the underlying molecular mechanisms in vitro in hepatic cells & in vivo in zebrafish models. Nobiletin significantly inhibited ANGPTL3 promoter activity & attenuated the transcription factor liver X receptor-α (LXRα)-mediated ANGPTL3 transcription.

   • According to SUZERY M (2023)

     Excerpt The current approach to breast cancer has problems with the emergence of resistance, side effects, & even the emergence of post-therapy relapses. This study aims to develop a CSP as a co-chemotherapy candidate that leads to aging induction & ROS modulation in breast cancer cells.

   • According to Cirmi S (2017)

     Excerpt Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus Medica fruits, Citrus fruits extract, cancer, neoplasm, neoplasia, tumor, metastasis, carcinogenesis, proliferation. During the last decades, a huge body of evidence has been accumulated suggesting that Citrus fruits & their juices might have a role in preventing many diseases including cancer.

   • According to Krishnakumari A (2011)

     Excerpt The aim of the present study was to develop naringenin-loaded Nanoparticles (NARNPs) & to evaluate the anticancer potency of the prepared NARNPs in human cervical (HeLa) cancer cells. Naringenin (NAR) is a naturally occurring plant bioflavonoid present in citrus fruits & possesses a wide range of biological application including anticancer effects.

3. 3

   Liver disease caused by acetaminophen/paracetamol

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to CHENG Y (2024)

     Excerpt It improves liver function, reduces inflammation & oxidative stress, remodels gut microflora, ameliorates hepatocellular necrosis, steatosis, & insulin resistance, & modulates biorhythms. Nobiletin (NOB) is a flavonoid derived from citrus peel that has potential as an alternative treatment for liver disease.

   • According to LIN CY (2022)

     Excerpt The aim of this study was to explore the lipid-lowering effects of nobiletin & the underlying molecular mechanisms in vitro in hepatic cells & in vivo in zebrafish models. Nobiletin significantly inhibited ANGPTL3 promoter activity & attenuated the transcription factor liver X receptor-α (LXRα)-mediated ANGPTL3 transcription.

   • According to Al-Ashaal H (2011)

     Excerpt Objective: The aim of the study is the isolation of hesperidin from the MEOH peel of Citrus sinensis L. Cytotoxic assay against larynx, cervix, breast & liver carcinoma cell lines was performed.

   • According to SHIBATO J (2025)

     Excerpt Middle-aged male mice (C57BL/6J) were exposed to Lavandula angustifolia (LO) & Citrus aurantium (CAO) essential oils for 7 weeks & compared to mice that did not receive EO inhalation treatment. The purpose of this study was to determine the effects of essential oil inhalation on body weight, blood lipid profile, & liver & adipose tissue in mice.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.