Clerodendrum paniculatum (Pagôd) : medicinal properties in alcoholic extraction
Clerodendrum paniculatum (Pagôd, Pagoda, Pagode) — family Lamiacées.
Scientific synonyms : Caprifolium paniculatum-N, Clerodendron diversifolium-Vahl, C pyramidale-And, C splendidum- Wall ex Griff, Volkameria angulata-Lour.
This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 6 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 39 scientific references for this species (full detail in the application).
Therapeutic indications in alcoholic extraction:
Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).
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Liver disorders: hepatitis, cirrhosis, fatty liver, abnormal serum levels: SGOT, SGPT, ALP, bilirubin, PT, etc.
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Kopilakkal R (2021)
Excerpt The aim of the presented work involves the isolation, characterization, & evaluation of hepatoprotective potential of Clerodendrum paniculatum flower extracts. Prominently, reduced levels of various associated enzymes along with increased protein content were observed when the liver specimen was pretreated with the extract.
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According to Kopilakka R (2020)
Excerpt Clerodendrum paniculatum has ethnomedicinal importance in treatment of disorders like wound, typhoid, jaundice, malaria & anemia. Objective: To evaluate the antioxidant & hepatoprotective activity of CP leaves against carbon tetrachloride (CCl4) induced rat model & identification of its bioactive constituents by Gas Chromatography Mass Spectroscopy (GC MS).
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According to Trang NT (2026)
Excerpt Clerodendrum paniculatum, which is widely distributed across tropical regions, is recognized for its medicinal value in Vietnam & other countries. Among the four plant parts, the root extract had the lowest IC₅₀ value (4.13 mg/mL), followed by the flower (4.70 mg/mL) & stem extracts (4.83 mg/mL), whereas the leaf extract displayed the highest value (5.23 mg/mL).
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According to Kopilakkal R (2021)
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Cancer: adjuvant treatment for lymphoma
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Yasir B (2022)
Excerpt This research aimed to optimize Pagoda’s extraction yields (Clerodendrum paniculatum L.) using several types of solvents & extraction techniques & to evaluate the cytotoxic activity of extracts obtained. These extracts were also very toxic to Artemia salina; therefore, they can be developed as anticancer.
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According to PHUNEERUB P (2015)
Excerpt Clerodendrum paniculatum L. Murine macrophage J774A.1 cells were stimulated by lipopolysaccharide (LPS) to evaluate nitric oxide (NO), tumor necrosis factor-α (TNF-α) & prostaglandin E 2 (PGE 2) production in the anti-inflammatory test while the mutagenic & antimutagenic potential was performed by the Ames test.
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According to Hegde NP (2023)
Excerpt The present study evaluates the phytochemical content & biological activities of eight Clerodendrum paniculatum leaf extracts obtained using four solvents of varying polarity & two extraction methods. Methanolic extracts from maceration & the Soxhlet method showed better cytotoxicity against breast & oral cancer cell lines, while the aqueous extract from maceration demonstrated better cytotoxicity against lung cancer cell lines.
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According to John J (2008)
Excerpt Ethno botanical search reveals use of many traditional herbs in treatment antioxidant phenolic compounds have been recognized to have ability to of cancer, which are usually free from side effects, are economical & also easily accessible to humans. Although, plants of the same genus were reported to possess potent anticancer activity [6] [7], no reports were available on this plant.
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According to YASIR B (2025)
Excerpt The methanol-extracted flower portion was subjected to maceration & the compounds were then isolated using various techniques, including silica gel, column chromatography, & preparative thin layer chromatography (PTLC), which yielded 3 types of compounds. In conclusion, 1H NMR spectrum & chemometrics detects the fingerprinting profile of Pagoda extract variations, clustering extracts, identifying marker compounds, & potential for cytotoxicity studies in cancer cells.
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According to Yasir B (2022)
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Osteoarthritis, arthritis, rheumatism, oedema
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Pertiwi D (2020)
Excerpt The Pagoda (Clerodendrum paniculatum L.) is a medicinal plant that is spread widely in the Asian region. The Pagoda is known to have the activity as antioxidant & anti-inflammatory activity, & have other activities that are believed to be potential medicinal plants.
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According to PHUNEERUB P (2015)
Excerpt This present study investigated the in vitro anti-inflammatory, mutagenic & antimutagenic activities of the ethanolic extract of CE (CPE) dried root collected from Sa Kaeo Province of Thailand. Clerodendrum paniculatum L.
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According to KUZMA L (2022)
Excerpt The diterpenoids isolated from Clerodendrum demonstrate a range of cytotoxic, anti-proliferative, antibacterial, anti-parasitic & anti-inflammatory activities. This review describes the various biological activities of the diterpenoids isolated so far from species of Clerodendrum with the indication of the most active ones, as well as those from other plant sources, taking into account their structure in terms of their activity, & summarises the methods for their extraction.
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According to John J (2008)
Excerpt The plants of the genus Clerodendron were reported to have antioxidant [10] & anti-inflammatory [8] [9] activities also. The plant Clerodendron paniculatum is a plant widely found in Udupi district of Karnataka, India.
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According to Joseph J (2013)
Excerpt This study was intended to evaluate the antiinflammatory activity of various extracts of fresh leaves of Clerodendrum paniculatum Linn experimentally by in vitro (human red blood cell membrane stabilization method) & in vivo methods (0.1 ml of 1% w/v carrageenan-induced rat paw oedema model). The results of the present study demonstrate that petroleum ether & chloroform extracts possess significant (P<0.001) antiinflammatory potential which provide scientific basis for the traditional claims of CP leaves as an antiinflammatory drug.
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According to Pertiwi D (2020)
Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.
Evolution of this plant record
Under the CTA · public change history
Available in Spanish
+3 indications · ~2 indications corrected · −4 indications · +28 references · ~10 references corrected · −4 references
Counts and domains only: indication labels and synergy names are not listed here (open the in-app plant file). Bibliographic texts for new, corrected, or removed references expand below.
+28 references — show text
Joseph J et al, antimicrobial activity of Clerodendrum paniculatum Linn leaves. Int.
AddedArun PV et al, Antioxidant potential of Clerodendrum paniculatum. Jl Pharm Res. 2011; 4:1796–9-
AddedJoseph J et al, Phytochemical screening & antioxidant activity of various extracts of Clerodendrum paniculatum Linn. World Jl Pharm Res. 2018;7(13):555-68.
AddedGOGOL V et al, Virtual Screening & Network Pharmacology-Based Study to Explore the Pharmacological Mechanism of Clerodendrum Species for Anticancer Treatment, Comp & Alter Med, 3106363., 2022-Abstract: Cancer is a second leading cause of death in the world, killing approximately 3500 per million people each year. Therefore, the drugs with multitarget pharmacology based on biological networks are crucial to investigate the molecular mechanisms of cancer drugs & repurpose the existing drugs to reduce adverse effects. Clerodendrum is a diversified genus with a wide range of economic & pharmaco…
AddedLeena PN et al, Isolation & spectral identification of quercetin from the alcoholic root extract of Clerodendrum paniculatum Linn. Int Jl Pharma Sci Res. 2016 ; 7(1):47-50.
AddedPavithra TR et al, Ethnomedicinal uses, phytochemical & pharmacological evaluation of Clerodendrum paniculatum: A comprehensive review. Int Jl Pharm Res Appl. 2023;8(5):1697-703.
AddedRemya K et al, Monograph of Clerodendrum paniculatum. World Jl Pharm Res. 2019;8(8):448-56.
AddedYASIR B et al, Chemometric-assisted fingerprinting profiling of the Pagoda (Clerodendrum paniculatum L.) extract variation using proton nuclear magnetic resonance (1H NMR) method, compound isolation, & cytotoxic activity, Jl of Res in Pharm, 29’3):971-84, 2025-Abstract: One of the best solutions to understanding the chemical data of complex natural substances is to use chemometric techniques. This research aims to apply chemometric techniques, specifically principal component analysis (PCA) & cluster analysis (CA), to determine the fingerprint profiles of nine pagoda extracts (PCP) & their …
AddedPRAHINA TS et al, investigation on phyto-active constituents of Clerodendrum paniculatum as therapeutic agent against viral diseases. Chem Select. 8(4): ae202203932. 2023-Abstract: the ability of alcohol extracted constituents from the leaves of Clerodendrum paniculatumto inhibit SARS-CoV-2 was investigated through various computational methods like docking, molecular dynamic simulations and pharmacokinetic predictions. Of the various active constituents, quercetin was identified as a potent inhibitor that can bind strongly to the active site of main protease (Mpro) and spike protein of the…
AddedKekuda TRP et al, phytochemistry & biological activities of Clerodendrum paniculatum L. (Lamiaceae): A comprehensive review. Jl Drug Deliv. Ther. 8(5-s):28 – 34. 2018-
AddedLeena PN et al, Estimation of total phenolic & flavonoid content in alcoholic root extract of Clerodendrum paniculatum by spectrophotometric method. Indo. Am. Jl. Pharm. Sci., 3, 348-50, 2016-
AddedTrang NT et al, Chemical Constituents & Bioactive Properties in Some Parts of Clerodendrum Paniculatum from Hue City, Vietnam, TROP jl of NAT PROD RES, 10:1, 2026-ABSTRACT: Clerodendrum paniculatum, which is widely distributed across tropical regions, is recognized for its medicinal value in Vietnam & other countries. It has been traditionally used for its therapeutic properties, but scientific evidence regarding its chemical composition & biological activities remains limited. The purpose of this research was to profile the phytochemical constituents & biological properties of various plan…
AddedNguyen TQ et al, Biochemical composition, polyphenol & flavonoid content, antibacterial activity of leaf & flower extracts of Clerodendrum paniculatum distributed in Thua Thien Hue Province, Viet Nam. Trop lJ Nat Prod Res. 2024;8(9):8275-81.
AddedPrashith Kekuda, T.R. et al, Ethnobotanical uses, phytochemistry & biological activities of Clerodendrum paniculatum L. (Lamiaceae): A comprehensive review, Jl. Drug Delivery Ther., 8 (5), 28–34. 2018-
AddedJadhav GS et al, Efficacy of certain Clerodendrum leaf crude extracts against cutworm, Spodoptera litura Fab & cotton bollworm, Helicoverpa armigera Hub. Jl of Entomol & Zool Studies, 2016; 4(4):466-72.
AddedSiddik ASNU et al, Antioxidant properties of Clerodendrum species found in Northeast India: A review. Jl. Pharmacogn. Phytochem. 2021; 10(4):390-4-
AddedHegde NP et al, Phytochemical profiling of Clerodendrum paniculatum leaf extracts: GC-MS, LC-MS analysis & comparative evaluation of antimicrobial, antioxidant & cytotoxic effects. Nat Prod Res. 2023;37(17):2957-64-Abstract : The present study evaluates the phytochemical content & biological activities of eight Clerodendrum paniculatum leaf extracts obtained using four solvents of varying polarity & two extraction methods. GC-HRMS analysis of the hexane extract predicted presence of phytol, 22-tritetracontanone, & 6,9,12-octadecatrienoic acid, phenyl methyl ester, (ZZZ)-as major compounds,…
AddedMusa W et al, The poriferasta compound-5,22e,25-trien-3-Oβ from Clerodendrum paniculatum leaf as inducer agent of systemic resistance on red chilli plant Capsicum annuum L from Cucumber Mosaic Virus (CMV), Indones. Jl. Chem., 9 (3), 479–86. 2009-
AddedHebbar DR et al, Phytochemicals & antioxidant activity of Clerodendrum paniculatum (L.) Leaf & flower extracts. Asian Jl. Pharm. Clin. Res. 2022; 15(1):31 – 4.
AddedKopilakka R et al, Evaluation of Hepatoprotective Activity of Clerodendrum paniculatum Leaf on Carbon Tetrachloride-Induced Liver Toxicity Model in Swiss Albino Rats & Its Characterization by GC-MS, Endocr., Metab. Immune Disord Drug Targets, 20 :1097, 2020-Abstract: Clerodendrum paniculatum has ethnomedicinal importance in treatment of disorders like wound, typhoid, jaundice, malaria & anemia. Objective: To evaluate the antioxidant & hepatoprotective activity of CP leaves against carbon tetrachloride (CCl4) induced rat model & identification of its bioactive constituents by Gas Chromatogr…
AddedPavithra TR et al, Pharmacognostical studies on stems of Clerodendrum paniculatum. Int J Res Publ Rev. 2024;5(8):2778-87.
AddedKUZMA L et al, Biologically Active Diterpenoids in the Clerodendrum Genus-A Review, Int JL of Mol Sci, 23(19):110001, 2022-Abstract: One of the key areas of interest in pharmacognosy is that of the diterpenoids; many studies have been performed to identify new sources, their optimal isolation & biological properties. An important source of abietane-, pimarane-, clerodane-type diterpenoids & their derivatives are the members of the genus Clerodendrum, of the Lamiaceae. Due to their diverse chemical nature, & the type of plant material, a range of extraction techniques are needed with various…
AddedPertiwi D et al, POTENTIAL BIOACTIVITIES OF ETHANOL, ETHYL ACETATE & n-HEXANE EXTRACTS FROM PAGODA LEAVES (Clerodendrum paniculatum L.), Rasayan Jl of Chem, 13(4) :2313-6, 2020-Abstract: The Pagoda (Clerodendrum paniculatum L.) is a medicinal plant that is spread widely in the Asian region. The Pagoda is known to have the activity as antioxidant & anti-inflammatory activity, & have other activities that are believed to be potential medicinal plants. To determine the strength of potential activities possessed by pagoda plants needs to be tested using the Brine Shrimp Lethality Test (BSLT) me…
AddedPraveen M et al. In vitro anthelmintic activity of Clerodendrum paniculatum Linn leaves. Res Jl Pharm Biol Chem Sci, 4(2):321, 2013-Abstract: The present study was undertaken for investigating and validating the traditional claims of Clerodendrum paniculatum Linn for its anthelminthic activity. Shade dried, powdered (40 mesh size) leaves of Clerodendrum paniculatum. Linn was macerated with Chloroform, Ethyl acetate, Methanol & Distilled water. Adult earthworms Eudrilus eugenia of 3-5 cm in length and 0.1-0.2 cm in width were used for all the experimental purposes due to its anatomical & phy…
AddedPriyanka K et al, Screening of aerial parts of the plant Clerodendrum paniculatum Linn for anti-convulsant activity. Res Jl Pharmacol & Pharmacodynamics. 2019;11(1):1-4-Abstract : The present study was undertaken for investigating & validating the traditional claims of Clerodendrum paniculatum Linn for its anti-convulsant activity. CP belongs to verbenacea family. Ethno medical importance of various species of Clerodendrum genus has been reported in various indigenous systems of medicines & folk medicines. It is used as a medicine for the treatment of sore eyes, urinary tract, gonorrhoea…
AddedARBA M et al, The Potential of Clerodendrum paniculatum Leaves Fraction as a 3-Chymotrypsin-Like (3CL) Protease Inhibitor of SARS-CoV-2, Home, 23:3, 2023-Abstract: We described the biological activity of the Clerodendrum paniculatum leaf fraction against the SARS-CoV-2 3-Chymotrypsin-like 3CL protease at the molecular level. This study applied LC-MS/MS to identify bioactive compounds from fractions, computational studies, & fluorescence resonance energy transfer (FRET) assays to ascertain their inhibitory activity. LC-MS/MS analysis of the three samples revealed that sample 1 contained 18 c…
AddedKatisart T et al. Acute Toxicity of Aqueous Extract of a Diabetic Folklore Recipe Thai Traditional Medicine in Rats. Trop. Jl. Nat. Prod. Re. 2023; 7(6):3168 – 3176.
AddedShruthi G et al, Bactericidal property of Clerodendrum paniculatum & Saraca Asoka against multidrug-resistant bacteria, restoring the faith in herbal medicine. Int Jl Pharm Sci Res. 2017; 8(9):3863 – 71.
AddedJohn J et al, Free radical scavenging & anticancer activity of Clerodendrum paniculatum. Pharmacologyonline. 2008; 3:730–43-Abstract: In the recent years, several induce apoptosis in various tumour cells of human origin. By virtue of their antioxidant property, they also prevent cell growth by inhibiting the proteins responsible for cell growth. Ethno botanical search reveals use of many traditional herbs in treatment antioxidant phenolic compounds have been recognized to have ability to of cancer, which are usually free from side effects, are economical & also easily accessible to humans. …
CorrectedPhontree K et al, Chemical constituents of the roots of Clerodendrum paniculatum. Chem Nat Compd. 2014; 50:950 – 1.
CorrectedYANTI MD et al, The Effectiveness of Clerodendrum Paniculatum. L against TNF- α in Rats Induced by S. Aureus, Proceedings of the Inter Conf health Informatic, 2019-Abstract: : Staphylococus Aureus is one of the mastitis causes which causes inflammation due to elevated levels of TNF- α . This study aimed to analyze the anti-inflammatory activity of bag flower leaf ( Clerodendrum Paniculatum L ) on TNF- α level in rats that is induced by SA bacteria. This study used post test only control group design with 15 samples of Strain Sprague Dawley rats divided into 3 groups. K (-) group as normal c…
CorrectedKekuda TRP et al. Ethnobotanical uses, phytochemistry & biological activities of Clerodendrum paniculatum L. (Lamiaceae): A comprehensive review. Jl Drug Deliv Ther. 8(5-s):28-34. 2018-
CorrectedPHUNEERUB P et al, in vitro anti-inflammatory, mutagenic & antimutagenic activities of ethanolic extract of Clerodendrum paniculatum root, Jl of Adv Pharmaceut Technol, 2015-Abstract: Clerodendrum paniculatum L. (Family Verbenaceae) has been used as an antipyretic & anti-inflammatory drug in traditional Thai medicine. This present study investigated the in vitro anti-inflammatory, mutagenic & antimutagenic activities of the ethanolic extract of CE (CPE) dried root collected from Sa Kaeo Province of Thailand. Murine macrophage J774A.1 cells were stimulated by lipopolysaccharide (LPS) to eval…
CorrectedYasir B et al. Optimization of pagoda (Clerodendrum paniculatum L.) extraction based on analytical factorial design approach, its phytochemical compound, & cytotoxicity activity. Egypt Jl Chem. 65(9):421-30. 2022-Abstract: This research aimed to optimize Pagoda’s extraction yields (Clerodendrum paniculatum L.) using several types of solvents & extraction techniques & to evaluate the cytotoxic activity of extracts obtained. The various solvents include water, methanol, hexane, & ethanol, while the extraction techniques used were maceration, microwave-assisted extraction (MAE), & reflux. T…
CorrectedVenkatesh S et al, Anti-diabetic activity of Clerodendrum paniculatum leaves by in vitro, in vivo & ex vivo methods. GSC Biol Pharm Sci. 16(1):211-8, 2021-Abstract : The present study has been undertaken to evaluate the in-vitro, in-vivo & ex-vivo anti-diabetic activity of leaves of chloroform extract Clerodendrum paniculatum (CECP). The extract was prepared by Soxhlet extraction. Phytochemical screening indicates the presence of flavonoids, phenols, carbohydrates etc. The anti-diabetic activity of extract was studied by in-vitro (alpha amylase inhibition & alpha glucosidase inhibition assa…
CorrectedJoseph J et al, Phytochemical characterization of the leaf extract of Clerodendrum paniculatum Linn. Jl ETIR. 2021;8(5):994-6.
CorrectedHafiz I et al, Antioxidant activity of pagoda flower (Clerodendrum paniculatum L.) ethanol extract using visible spectrophotometric method. Indones Jl Pharm Clin Res. 2019;2(2):14-9-Abstract : Pagoda flower is one of the plant species included in the genus Clerodendrum which has a number of different species of 580 species, & is spread evenly in Asia, Africa, America, & Australia. A number of species of this genus have been used in traditional medicine in Asia & Africa. India, China, Korea, Thailand & Japan. The antioxidant activity of this plant is known to be very strong, so in this artic…
CorrectedJoseph J et al, In vitro & in vivo anti-inflammatory activity of Clerodendrum paniculatum Linn. leaves. Indian Jl Pharm Sci. 75(3):376-9, 2013-Abstract : Preliminary phytochemical screening showed the presence of terpenes, flavonoids, tannins, alkaloids, phenolic acid, sterols, & glycosides. This study was intended to evaluate the antiinflammatory activity of various extracts of fresh leaves of Clerodendrum paniculatum Linn experimentally by in vitro (human red blood cell membrane stabilization method) & in vivo methods (0.1 ml of 1% w/v carrageenan-induced rat paw oedema model). Petroleum…
CorrectedKrishnan R et al, in VITRO ANTI-SKIN AGEING BENEFITS OF CLERODENDRUM PANICULATUM LEAF EXTRACTS. World J of Pharmaceut Res, 2017-Abstract: Clerodendrum paniculatum (Family: Lamiaceae) or Hanuman kireetam is a well-known ayurvedic plant but less explored in India. The objective of the present study was to check the anti-skin ageing benefits of methanol & water extracts of CP leaves In vitro. The Collagen-I, Elastin & Hyaluronidase assays was performed on Human dermal fibroblast cells (HDF).The antioxidant potential of CP leaf water (CPW) & methanol extracts (CPM) was checked by reducing power…
RemovedVarghese S et al, Antidiabetic & antilipidemic effect of Clerodendrum paniculatum flower ethanolic extract. An in vivo investigation in Albino Wistar Rats, Biocatalysis & Agric Biotechnol, 36(6):102095, 2021-Abstract: The goal was to evaluate the effects of ethanolic extract of Clerodendrum paniculatum flower (CPF) on antidiabetic & antilipidemic tests indices of experimentally-induced hyperglycemic rats. Methods :High Fat Diet (HFD) treated Streptozotocin (STZ) induced diabetic rats were used for this study. The acute toxicity of ethanolic extract of CP flower (2000mg/kg body weight) & ant…
RemovedHafiz I et al, Antioxidant & anti-inflammatory activity of pagoda leaves (clerodendrum paniculatum l.) ethanolic extract in white male rats (Rattus novergicus), Int. J. PharmTech Res., 9(5) :165-170. 2016-Abstract: Clerodendrum paniculatum leaves had potential antioxidant & antiinflammation. The CP leaves were obtained from Berastagi, North Sumatera Province, Indonesia. The leaves of CP were dried at 50-60oC andmilled into powder. The dried leaves powder was extracted with ethanol by maceration method. Extract from solvent were concentrated by a rotary evaporator. The aim of the study was t…
RemovedKalonio DE et al, Anticancer Activity of Plant Genus Clerodendrum (Lamiaceae): A Review, Home, 22:3, 2017-Abstract: Plants of the genus Clerodendrum is widespread in tropical & subtropical regions. Plants of this genus are used both empirically & scientifically as anti-inflammatory, antidiabetic, antimalarial, antiviral, antihypertensive, hypolipidemic, antioxidant, & antitumor. Results of the molecular docking simulation of chemical content of these plants could potentially provide an anticancer effect. This paper aims to review the anticancer activity of plant genus Clerodendrum based on …
Removed