Clerodendrum paniculatum (Pagôd) : medicinal properties in alcoholic extraction

Clerodendrum paniculatum (Pagôd, Pagoda, Pagode) — family Verbénacées.

Scientific synonyms : Clerodendron pyramidale-And, Clerodendrum diversifolium-V, C pyramidale-And, C splendidum -Vahl ex G, Volkameria-Lour.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 15 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Varghese S (2021)

     Excerpt The goal was to evaluate the effects of ethanolic extract of Clerodendrum paniculatum flower (CPF) on antidiabetic & antilipidemic tests indices of experimentally-induced hyperglycemic rats. The acute toxicity of ethanolic extract of CP flower (2000mg/kg body weight) & antidiabetic effect of CPF (200mg/kg body weight) were studied in rats.

   • According to Author (2021)

     Excerpt The anti-diabetic activity of extract was studied by in-vitro (alpha amylase inhibition & alpha glucosidase inhibition assay), in-vivo (streptozotocin induced diabetes) & ex-vivo (glucose uptake by rat hemi-diaphragm method). The present study has been undertaken to evaluate the in-vitro, in-vivo & ex-vivo anti-diabetic activity of leaves of chloroform extract Clerodendron paniculatum (CECP).

   • According to Kalonio DE (2017)

     Excerpt Plants of this genus are used both empirically & scientifically as anti-inflammatory, antidiabetic, antimalarial, antiviral, antihypertensive, hypolipidemic, antioxidant, & antitumor. A total 12 plants of the genus Clerodendrum have anticancer activity in vitro & in vivo, thus potentially to be developed as a source of new active compounds with anticancer activity,.

2. 2

   Cancer: adjuvant treatment for ascites carcinoma

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to John J (2008)

     Excerpt Although, plants of the same genus were reported to possess potent anticancer activity, no reports were available on this plant. The present study was undertaken to evaluate the possible anticancer effects of alcoholic extract of the plant.

   • According to Yasir B (2022)

     Excerpt This research aimed to optimize Clerodendrum paniculatum using several types of solvents & extraction techniques & to evaluate the cytotoxic activity of extracts obtained. These extracts were also very toxic to Artemia salina; therefore, they can be developed as anticancer.

   • According to Kalonio DE (2017)

     Excerpt A total 12 plants of the genus Clerodendrum have anticancer activity in vitro & in vivo, thus potentially to be developed as a source of new active compounds with anticancer activity,. This paper aims to review the anticancer activity of plant genus Clerodendrum based on scientific data.

   • According to Phontree K (2014)

     Excerpt Clerodendrum paniculatum L. In continuation of our search for anticancer compounds of Thai medicinal plants, we have examined the CH2Cl2 extract of this plant for cytotoxic constituents [3].

   • According to Phuneerub P (2015)

     Excerpt Clerodendrum paniculatum L. Murine macrophage J774A.1 cells were stimulated by lipopolysaccharide (LPS) to evaluate nitric oxide (NO), tumor necrosis factor-α (TNF-α) & prostaglandin E2 (PGE2) production in the anti-inflammatory test while the mutagenic & antimutagenic potential was performed by the Ames test.

3. 3

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to John J (2008)

     Excerpt The plants of the genus Clerodendron were reported to have antioxidant & anti-inflammatory activities also.

   • According to Kalonio DE (2017)

     Excerpt Plants of this genus are used both empirically & scientifically as anti-inflammatory, antidiabetic, antimalarial, antiviral, antihypertensive, hypolipidemic, antioxidant, & antitumor. A total 12 plants of the genus Clerodendrum have anticancer activity in vitro & in vivo, thus potentially to be developed as a source of new active compounds with anticancer activity,.

   • According to Hafiz I (2016)

     Excerpt The antiinflammatory activity was evaluated by paw edema & granuloma cotton pellet method. Clerodendrum paniculatum leaves had potential antioxidant & antiinflammation.

   • According to Joseph J (2013)

     Excerpt This study was intended to evaluate the antiinflammatory activity of various extracts of fresh leaves of Clerodendrum paniculatum experimentally by in vitro (human red blood cell membrane stabilization method) & in vivo methods (0.1 ml of 1% w/v carrageenan-induced rat paw oedema model). The results of the present study demonstrate that petroleum ether & chloroform extracts possess significant (P<0.001) antiinflammatory potential which provide scientific basis for the traditional claims of CP leaves as an antiinflammatory drug,.

   • According to Joseph J (2021)

     Excerpt Cleroendrum paniculatum is traditionally used in India, Japan & China for the treatment of numerous ailments like inflammation, neuralgia, ulcer, rheumatism & wounds.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.