Crescentia cujete (Kalbas) : medicinal properties in alcoholic extraction

Crescentia cujete (Kalbas, Calabash, Calebasse) — family Bignoniacées.

Scientific synonyms : Crescentia microcarpa-Bello..

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 16 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 49 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Bacterial infection: Staphylococcus aureus & Escherichia coli

   Plant part used: Stem bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hasanah U (2016)

     Excerpt aureus) & Escherichia coli (E. Crescentia cujete has been known as a medicine for various diseases that caused by microorganisms.

   • According to Nurjanah S (2021)

     Excerpt The purpose of this study was to determine the potential of CC leaf extract in cream dosage form and to prove the presence of Antibacterial activity against Staphylococcus aureus. Crescentia cujete is a plant that has medicinal properties for various diseases.

   • According to Parvin MS (2015)

     Excerpt Again, in in vitro antibacterial study, the extractives exhibited potent antibacterial activity.

   • According to Chukwunonye UCE (2017)

     Excerpt Chukwunonye UCE et al, PHARMACOGNOSTIC STUDIES AND ANTIMICROBIAL ACTIVITY OF CRESCENTIA CUJETE LINNAEUS STEM BARK (BIGNONIACEAE) Indo American J of Pharmaceut Sci, 2017; 4(02):484-90,.

   • According to Honculada MO (2017)

     Excerpt This study focused on the antimicrobial potential of the fruit of Crescentia cujete against common infections Staphylococcus aureus, a gram-positive bacteria, & Escherichia coli which is a gram-negative bacterium. Findings of this study, however, revealed no antibacterial effect of the fruit extract against S aureus & E coli.

2. 2

   Cancer: adjuvant treatment for breast cancer

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Anjar Mahardian-Kusuma (2016)

     Excerpt This study was conducted to see the Cytotoxic potential of ethanol extract of leaves berenuk (EEDB) in T47D Breast cancer cells using MTT assay. Crescentia cujete is a plant that thrives in Indonesia.

   • According to Tambole RJI (2013)

     Excerpt In this study, the pericarp of the Calabash (Crescentia Cujete) is utilized as an effective treatment for stopping tumour vascularisation. The researcher concluded that the Calabash Fruit Pericarp has anti-angiogenic effect thus having the potential of halting tumor vascularisation,.

   • According to Oladunni BF (2021)

     Excerpt Crescentia cujete is an economical & medicinal plant of wide indigenous uses including hypertension, diarrhea, respiratory ailments, stomach troubles, infertility problems, cancer, & snakebite. cujete are mainly from Asia & South America (Philippines, Bangladesh, India, etc.), part of the persistence challenge is lack of comprehensive data on the plant from in vivopharmacological studies of its already characterized compounds for probable clinical trials toward drug discovery.

3. 3

   Rheumatism, osteoarthritis, arthritis

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Parvin MS (2015)

     Excerpt All the samples showed a dose dependent anti-inflammatory activity in HRBC membrane stabilization test.

   • According to Anjar Mahardian-Kusuma (2016)

     Excerpt Crescentia cujete is a plant that thrives in Indonesia. Among recent study conducted at the Faculty of Pharmacy UMP showed that the ethanol extract of berenuk leaves with a concentration of 60% & 80 % can significantly accelerate the cessation of surface skin bleeding on mice (Kusuma & Sabikis, 2012), as well as having antiinflammatory activity (antiinflammatory) in mice in vivo by doses of 1680, 3360 and 6720 mg/kg (Kusuma & Susanti, 2013).

   • According to Oladunni BF (2021)

     Excerpt The review established the antidiabetic, antioxidant, acaricidal, antibacterial, anti-inflammatory, anthelmintic, antivenom, wound healing, neuroprotection, antiangiogenic, & cytotoxic properties from aqueous & organic (particularly ethanol) aerial parts attributed to several secondary metabolites such as flavonoids, alkaloids, saponins, tannins, phenols, cardiac glycosides, phytosterols, reducing sugar, & volatile oils. Crescentia cujete is an economical & medicinal plant of wide indigenous uses including hypertension, diarrhea, respiratory ailments, stomach troubles, infertility problems, cancer, & snakebite.

   • According to Tambole RJI (2013)

     Excerpt In this study, the pericarp of the Calabash (Crescentia Cujete) is utilized as an effective treatment for stopping tumour vascularisation. The mesh indices of the different concentration (25%, 50%, 100%) of the extracts, & the positive & negative control were the following: 285.663, 280.534, 166.008, 176.162, & 244.049.The result of the Chorioallontoic Membrane Assay showed that the extract showed no significant difference to the positive control so it is showed that the extract also has anti-angiogenic effect to the chick embryo.

   • According to Das N (2014)

     Excerpt The aim of this study was to investigate the antioxidant activity in vitro, total phenolic & flavonoid contents in ethanol extracts & fractions of Crescentia cujete leaves & stem bark.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.