Cucurbita maxima (Pumpkin) : medicinal properties in alcoholic extraction

Cucurbita maxima (Pumpkin, Jiwomon wouj, Red Giromon, Potiron, Giromon rouge) — family Cucurbitacées.

Scientific synonyms : Cucurbita farinae Mozz. Ex Naudin, Cucurbita pileiformis M. Roem, . Curcubita tirbaniformis M. Roem..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 74 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus: synergistic effect when combined with raw pulp juice

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lal VK (2016)

     Excerpt Approach: The present study was to evaluate the hypoglycemic activity of fruit juice & hydro-alcoholic extract of Cucurbita maxima for validation of its folkloric use. Oral daily administration of both fruit juice & extract led to significant decrease in hyperglycemia as compared to unfed diabetic control.

   • According to Sharma S (2013)

     Excerpt The objective of the present study was to evaluate the antidiabetic & antihyperlipidemic effect of petroleum ether, ethyl acetate & alcohol extract of seeds of Cucurbita maxima for its purported use in diabetes. Administration of Glibenclamide, a reference drug also produced a significant (P<0.05) reduction in blood glucose concentration in streptozotocin induced diabetic rats.

   • According to Gabal Alyae MS (2016)

     Excerpt Aim of the Work: This work aimed to investigate the possible anti-diabetic effect of oral administration of pumpkin (Cucurbita maxima) fruit flesh & seeds powders on Streptozotocin induced diabetic rats via studying blood glucose levels, oxidative biomarkers as well as islets of Langerhans structure changes. Diabetes mellitus is the one of the most common endocrine diseases that is characterized by hyperglycemia, altered metabolism with an increased risk of much complications.

   • According to Kumar KD (2016)

     Excerpt The glycemic elemental profile further validates their role in controlling diabetes & hence CM seeds could be explored as a potential herbal candidate for managing postprandial hyperglycemia causing type 2 diabetes mellitus. The aim of the present study was to investigate, α-amylase & α-glucosidase inhibitory activities of the aqueous extract of Cucurbita maxima seeds in vitro & to correlate their activity with their phytoelemental profile quantitatively assessed by Laser-Induced Breakdown Spectroscopy (LIBS).

   • According to Saha P (2011)

     Excerpt Saha P et al, Antidiabetic Activity of Cucurbita maxima Aerial Parts, Res Jl of Med Plant, 2011; 5 (5): 577-86-DOI: 10.3923/rjmp.2011.577.586,.

2. 2

   Cancer; adjuvant treatment of ascites and uterine carcinoma

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Saha P (2011)

     Excerpt Saha P et al, Anticancer activity of methanol extract of Cucurbita maxima against Ehrlich ascites carcinoma, Int J Res Pharm.

   • According to HASNAT A (2023)

     Excerpt maxima reported to have medicinal properties & pharmacological activities like anti-inflammatory, antioxidant & anti-microbial activity. the most frequent cancer in women worldwide is breast cancer, it is also the second leading cause of cancer-related death in women.

   • According to Jawad T (2014)

     Excerpt Cucurbita maxima (CM) seed oil is commonly used in Indian folk medicine to treat various ailments. The effects of scopolamine on the levels of the tumour necrosis factor alpha (TNF-α) transcript were also investigated. P (2014) — excerpt: P et al, HPLC, GC-MS & in-silico analysis of Cucurbita maxima methanolic extract for its activity against Prostate Cancer.

   • According to Muruganantham N (2016)

     Excerpt Muruganantham N et al, Anti-cancer activity of Cucurbita maxima flowers (Pumpkin) against human liver cancer, Inter Jl of Pharm Sci, 6, 1 (2016): 1356-9-Abstract:.

3. 3

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Cruz RCB (2006)

     Excerpt Pumpkin seeds of Cucurbita maxima are frequently used for stomach pain, as an anti-inflammatory & antipyretic, & for the treatment of worms.

   • According to Patel H (2013)

     Excerpt Patel H et al, EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF CUCURBITA MAXIMA FRUIT, Jl Adv Pharm Res Biosci.

   • According to Pshyk-Titko I (n.d.)

     Excerpt Pshyk-Titko I et al, Anti-inflammatory effect of Cucurbita maxima sweet seed extract on foregut induced injury: role of oxidative stress, The FASEB J.

   • According to Wahid S (2021)

     Excerpt Thus, the current study was designed to evaluate the safety profile & explore the analgesic & anti-inflammatory activity of ethanol extract of Cucurbita maxima & Cucumis sativus seeds. Anti-inflammatory activity was evaluated by rat hind paw edema method.

   • According to HASNAT A (2023)

     Excerpt maxima reported to have medicinal properties & pharmacological activities like anti-inflammatory, antioxidant & anti-microbial activity. The outcomes revealed high anti-oxidant activity of the extract 0.781 ± 0.016 in 100 µg/ml & anti-microbial activity showed the most prominent activity of the extract against all the tested microorganisms.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.