Daucus carota (Kawôt) : medicinal properties in alcoholic extraction

Daucus carota (Kawôt, carrot, carote) — family Apiacées.

Scientific synonyms : Daucus esculentus-Salisb, D siculus-Tineo.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 58 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Pain

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Vasudeva M (2006)

     Excerpt The ethanolic extract of Daucus carota seeds (DCE) was investigated for anti-inflammatory & analgesic activity at the doses [per oral (p.o.)] of 100, 200 & 400 mg/kg body weight. For evaluation of inflammation carrageenan-, histamine- & serotonin-induced paw edema served as acute models & formaldehyde-induced arthritis served as a chronic model in rats.

   • According to Wehbe K (2009)

     Excerpt Wehbe K et al, the potential role of Daucus carota aqueous & methanolic extracts on inflammation & gastric ulcers in rats.

   • According to Osman AF (2018)

     Excerpt In researcher’s previous study it has been found that the 80% ethanolic extract of Daucus carota canopy L was the most active extract for antibacterial activity and its phytochemical screening led to the isolation and identification of 12 natural flavone compounds including the new C-glycoside; 6,8-Di-C-α-L-rhamnosides diosmetin besides 11 known compounds. The primary objective of the present work is to investigate the 80% EtOH extract of D carota canopy L for its antioxidant, analgesic & cytotoxic activities and the new compound for its cytotoxic activity.

   • According to Al-Snafi A (n.d.)

     Excerpt The pharmacological studies revealed that the plant possessed cytotoxic, antioxidant, antidiabetic, antimicrobial, smooth muscle relaxant, hypotensive effect and decrease intraocular pressure, gastroprotective, nephroprotective, hepatoprotective, cardioprotective antidepressant memory enhancement, anti-inflammatory, reproductive, wound healing and hear induction and many other effects. - Phytochemical analysis showed that the root of Daucus carota contained alkaloids, carbohydrates, Chlorogenic acid, flavonoids, phenols, essential oil, Terpenoid and coumarin.

   • According to Valente I (2015)

     Excerpt The present study was conducted to elucidate the composition, antifungal & anti-inflammatory activities & cytotoxicity of Daucus carota subsp. gummifer essential oil should be explored as a natural source of antifungal & anti-inflammatory drugs with potential application both at the peripheral & central nervous system levels, thus supporting in vivo studies focused in the management of dermatophytosis and/or inflammatory-related diseases.

2. 2

   Cancer: adjuvant treatment for gastric carcinoma

   Plant part used: Fruit. Mentioned synergistic association: Lycopersicon esculentum- fruits.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Chauhan M (2023)

     Excerpt (amla), & Lycopersicon esculentum M (tomatoes) are traditionally consumed functional foods that contain a high concentration of antioxidants, ascorbic acid, polyphenols, & numerous phytochemicals. The LS extract was tested in the MKN-45 human gastric cancer cell line to demonstrate its effective antioxidant potential & cytotoxicity.

   • According to Zeinab RA (2011)

     Excerpt CONCLUSION: These findings demonstrate that DCOE has remarkable antitumor activity against DMBA-induced skin cancer compared with non-treated animals paving the ground for further investigations. carota umbels on 7, 12-dimethyl Benz (a) anthracene (DMBA)-induced skin cancer in mice.

   • According to Shebaby WN (2013)

     Excerpt the present study investigates the in vitro anticancer activities of Daucus carota oil extract (DCOE) on four human cancer cell lines as well as its in vitro antioxidant activity. The anticancer activity of the oil extract against human colon (HT-29, Caco-2) & breast (MCF-7, MDA-MB-231) cancer cell lines was evaluated using the trypan blue exclusion method and the WST-1 cell proliferation assay.

   • According to Wehbe K (2009)

     Excerpt Wehbe K et al, the potential role of Daucus carota aqueous & methanolic extracts on inflammation & gastric ulcers in rats.

   • According to Mroueh M (2013)

     Excerpt This study aims to determine the anticancer activity of the pentane fraction (F1) & the 1:1 pentane: diethyl ether fraction (F2) of the D Carota oil extract (DCOE) against human colon adenocarcinoma cell lines (HT-29 & Caco-2). carota (Apiaceae, wild carrot, Queen Anne's lace) has been used in folk medicine throughout the world and recently was shown to possess anticancer & antioxidant activities.

3. 3

   High blood pressure, oedema, fluid retention

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Vasudeva M (2006)

     Excerpt The ethanolic extract of Daucus carota seeds (DCE) was investigated for anti-inflammatory & analgesic activity at the doses [per oral (p.o.)] of 100, 200 & 400 mg/kg body weight. For evaluation of inflammation carrageenan-, histamine- & serotonin-induced paw edema served as acute models & formaldehyde-induced arthritis served as a chronic model in rats.

   • According to Wehbe K (2009)

     Excerpt Wehbe K et al, the potential role of Daucus carota aqueous & methanolic extracts on inflammation & gastric ulcers in rats.

   • According to Al-Snafi A (n.d.)

     Excerpt The pharmacological studies revealed that the plant possessed cytotoxic, antioxidant, antidiabetic, antimicrobial, smooth muscle relaxant, hypotensive effect and decrease intraocular pressure, gastroprotective, nephroprotective, hepatoprotective, cardioprotective antidepressant memory enhancement, anti-inflammatory, reproductive, wound healing and hear induction and many other effects. - Phytochemical analysis showed that the root of Daucus carota contained alkaloids, carbohydrates, Chlorogenic acid, flavonoids, phenols, essential oil, Terpenoid and coumarin.

   • According to Gilani AH (2000)

     Excerpt Intravenous administration of these compounds caused a dose-dependent (1-10 mg/kg) fall in arterial blood pressure in normotensive anaesthetised rats. Daucus carota (carrot) has been used in traditional medicine to treat hypertension.

   • According to Valente I (2015)

     Excerpt The present study was conducted to elucidate the composition, antifungal & anti-inflammatory activities & cytotoxicity of Daucus carota subsp. gummifer essential oil should be explored as a natural source of antifungal & anti-inflammatory drugs with potential application both at the peripheral & central nervous system levels, thus supporting in vivo studies focused in the management of dermatophytosis and/or inflammatory-related diseases.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.