Dillenia indica (elephant apple) : medicinal properties in alcoholic extraction

Dillenia indica (elephant apple, pomme d’elephant) — family Dilleniacées`.

Scientific synonyms : Dillenia speciosa-Thumb.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 16 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 63 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Diabetic neuropathy, pain, allodynia, CNV

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to KAUR N (2017)

     Excerpt indica & its isolate, chromane (CR), on thermal & mechanical hyperalgesia, allodynia, MNCV & oxidative-nitrosative stress in streptozotocin-induced experimental diabetes. indica might be beneficial in chronic diabetics, ameliorate the progression of diabetic neuropathy & may also find application in diabetic neuropathic pain.

   • According to Kumar S (2011)

     Excerpt The present study was carried out to evaluate antidiabetic & antihyperlipidemic effects of Dillenia indica methanolic leaves extracts in streptozotocin induced diabetic Wistar rats by administering graded oral doses (250&d 500 mg/kg body weight) for 21 days. indica leaf extract might be useful for diabetes mellitus management & other abnormalities associated with this metabolic disorder.

   • According to Khan S (2019)

     Excerpt Methods & findings Type 2 diabetes (T2D) was induced by a single intraperitoneal injection of Streptozotocin (STZ; 90mg/kg) & hyperlipidemia by feeding with 1% cholesterol, 5% coconut oil and 5% cow fat diet. Dillenia indica can suppress carbohydrates hydrolysis by inhibiting α-amylase & α-glucosidase.

   • According to Kumar S (2011)

     Excerpt Kumar S et al, Antidiabetic, hypolipidemic & histopathological analysis of Dillenia indica (L.) leaves extract on alloxan induced diabetic rats, Asian Pac J of Trop Med, 4(5) :347–52, 2011.

   • According to Kumar S (2013)

     Excerpt Kumar S et al, Enzymes Inhibition & Antidiabetic Effect of Isolated Constituents from Dillenia indica, Bio-Med Res Inter, ID 382063, 2013.

2. 2

   Diabetic nephropathy

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Khan S (2019)

     Excerpt Methods & findings Type 2 diabetes (T2D) was induced by a single intraperitoneal injection of Streptozotocin (STZ; 90mg/kg) & hyperlipidemia by feeding with 1% cholesterol, 5% coconut oil and 5% cow fat diet. Dillenia indica can suppress carbohydrates hydrolysis by inhibiting α-amylase & α-glucosidase.

   • According to Kumar S (2011)

     Excerpt The present study was carried out to evaluate antidiabetic & antihyperlipidemic effects of Dillenia indica methanolic leaves extracts in streptozotocin induced diabetic Wistar rats by administering graded oral doses (250&d 500 mg/kg body weight) for 21 days. indica leaf extract might be useful for diabetes mellitus management & other abnormalities associated with this metabolic disorder.

   • According to KAUR N (2017)

     Excerpt indica & its isolate, chromane (CR), on thermal & mechanical hyperalgesia, allodynia, MNCV & oxidative-nitrosative stress in streptozotocin-induced experimental diabetes. Material & methods : Diabetes was induced by intraperitoneal administration of Streptozotocin (STZ; 65 mg/kg) for the development of diabetic neuropathy.

   • According to Kumar S (2011)

     Excerpt Kumar S et al, Antidiabetic, hypolipidemic & histopathological analysis of Dillenia indica (L.) leaves extract on alloxan induced diabetic rats, Asian Pac J of Trop Med, 4(5) :347–52, 2011.

   • According to Kumar S (2013)

     Excerpt Kumar S et al, Enzymes Inhibition & Antidiabetic Effect of Isolated Constituents from Dillenia indica, Bio-Med Res Inter, ID 382063, 2013.

3. 3

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kumar S (2011)

     Excerpt The present study was carried out to evaluate antidiabetic & antihyperlipidemic effects of Dillenia indica methanolic leaves extracts in streptozotocin induced diabetic Wistar rats by administering graded oral doses (250&d 500 mg/kg body weight) for 21 days. indica leaf extract might be useful for diabetes mellitus management & other abnormalities associated with this metabolic disorder.

   • According to KAUR N (2017)

     Excerpt indica & its isolate, chromane (CR), on thermal & mechanical hyperalgesia, allodynia, MNCV & oxidative-nitrosative stress in streptozotocin-induced experimental diabetes. Material & methods : Diabetes was induced by intraperitoneal administration of Streptozotocin (STZ; 65 mg/kg) for the development of diabetic neuropathy.

   • According to Khan S (2019)

     Excerpt Methods & findings Type 2 diabetes (T2D) was induced by a single intraperitoneal injection of Streptozotocin (STZ; 90mg/kg) & hyperlipidemia by feeding with 1% cholesterol, 5% coconut oil and 5% cow fat diet. Dillenia indica can suppress carbohydrates hydrolysis by inhibiting α-amylase & α-glucosidase.

   • According to Kumar S (2011)

     Excerpt Kumar S et al, Antidiabetic, hypolipidemic & histopathological analysis of Dillenia indica (L.) leaves extract on alloxan induced diabetic rats, Asian Pac J of Trop Med, 4(5) :347–52, 2011.

   • According to Kumar S (2013)

     Excerpt Kumar S et al, Enzymes Inhibition & Antidiabetic Effect of Isolated Constituents from Dillenia indica, Bio-Med Res Inter, ID 382063, 2013.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.