Elephantopus mollis (Rabbit-ear) : medicinal properties in alcoholic extraction

Elephantopus mollis (Rabbit-ear, Sheep-ear, Little sheep-ear, Zorèy-lapen, Ti zorèy-mouton, Oreille-à-lapin, Petite oreille-à -mouton) — family Astéracées.

Scientific synonyms : Elephantopus pilosa-Philipson, E. Scaber-Griseb-n L.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 21 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 96 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: Adjuvant treatment of carcinoma: ascites, colorectal, liver, breast, lung, leukaemia, carcinosarcoma, osteosarcoma

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bich Ngoc TT (2020)

     Excerpt Previous studies reported that crude extracts of this plant could inhibit several cancer cell lines, including breast carcinoma MCF-7, liver carcinoma HepG2, colorectal carcinoma DLD-1, lung carcinoma NCI–H23, etc. Elephantopus mollis Kunth (EM), which belongs to Asteraceae family, has been used as a folk medicine with diverse therapeutic properties.

   • According to Liang QL (2008)

     Excerpt A new elemanolide sesquiterpene lactone, named elescaberin (1), together with two known compounds, namely, Isodeoxyelephantopin (2) & Deoxyelephantopin (3), was isolated from the whole plant of Elephantopus scaber. All three compounds exhibited significant inhibitory activities against human SMMC-7721 liver cancer cells in vitro (50-IC 8.18–14.08 μmol/l).

   • According to Ho WY (2012)

     Excerpt These results suggest the potential effect of this extract as a hepatoprotective agent towards-ethanol induced liver damage without any oral acute toxicity effect. Accelerating serum biochemical profiles (including AST, ALT, ALP, triglyceride, and total Bilirubin) associated with fat drop and necrotic body in the liver section were observed in the mice treated with ethanol.

   • According to Linza A (2013)

     Excerpt Linza A et al, Dose-response effects of Elephantopus scaber methanolic extract on N-nitrosodiethylamine-induced hepatotoxicity in rats, Chinese J of Nat Med, 2013; 11 (4):362-370,.

   • According to Hung HF (2011)

     Excerpt Hung HF et al, Elephantopus scaber inhibits lipopolysaccharide-induced liver injury by suppression of signaling pathways in rats.

2. 2

   Bacterial infection: Enterococcus faecalis, Proteus mirabilis, Salmonella Typhi, Enterobacter sp., -n

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Anitha VT (2012)

     Excerpt To examine the ethanol, aqueous, chloroform, benzene, acetone & petroleum ether extracts of, Hemigraphis colorata leaves & stem & Elephantopus scaber leaves, root & flower for the presence of phytoconstituents & screened the antibacterial activity against the selected pathogens. Aqueous, acetone, benzene, chloroform, ethanol, & petroleum ether extracts were prepared from powdered materials were used for preliminary phytochemical & antimicrobial studies using standard methods.

   • According to Manaf AA (1996)

     Excerpt Cytotoxic activity was present in the extracts from Acalypha indica, Andrographis paniculata, Cerbera manghas, Codiaeum variegatum, Cosmos caudatus, Elephantopus scaber, Etlingera elatior, Eugenia michelii, Freycinetia malaccensis, Hibiscus rosa-sinensis, Centella asiatica, L ollaria, Mentha arvensis, Mirabilis Jalapa, M elliptica, Ocimum tenuiflorum, Piper sarmentosum & Polygonum minus (CD50: 0.001-0.1 mg. Selective activity against VSV was shown by the extracts from Acalypha indica, Bertholletia excelsa, Cerbera manghas, Codiaeum variegatum, Plectranthus amboinicus, Centella asiatica, Mirabilis Jalapa, Morinda elliptica, Œnanthe javanica, Piper sarmentosum & Premna odorata (MIG: 0.005-0.1 mg/ml).

   • According to Jasmine R (2007)

     Excerpt Jasmine R et al, Evaluating the Antibacterial Activity of Elephantopus scaber Extracts on Clinical Isolates of β-lactamase Producing Methicillin Resistant Staphylococcus aureus from UTI Patients, Int.

   • According to Kamala-Kannan P (2012)

     Excerpt Kamala-Kannan P et al, Study of phytochemical & antimicrobial potential of methanol & aqueous extracts of aerial parts of Elephantopus scaber L.

   • According to Hiradeve SM (2015)

     Excerpt Hiradeve SM et al, Antibacterial & antifungal activities of Elephantopus scaber Linn.

3. 3

   Arthritis, osteoarthritis, rheumatism, oedema

   Plant part used: aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Han Y (2020)

     Excerpt Our study indicates that IDET might be a promising constituent from the anti-inflammatory herb E scaber in mitigating inflammatory conditions, especially respiratory inflammation,. Since the occurrence & development of cancer usually accompany with inflammation, & tumor signaling shares many components with inflammation signaling, the agents with anti-tumor activity are likely to possess anti-inflammation potential.

   • According to Sankar V (2001)

     Excerpt To study the antiinflammatory activity of Elephantopus scaber in acute, subacute and chronic experimental models in albino rats, aerial parts of E scaber were extracted with hydroalcoholic solvent & purified by chromatographic procedure. The pouch was opened on day 7 under anaesthesia & the exudates collected by a syringe was measured the compound was also investigated in formalin-induced oedema models in rats.

   • According to Chan C (2018)

     Excerpt Elephantopus scaber has been traditionally utilized as a folkloric medicine a&scientifically shown to exhibit anti-inflammatory activities in various in vivo inflammatory models. Taken altogether, the cumulative findings suggested that ESEAF holds the potential to develop as nutraceutical for the intervention of neuroinflammatory disorder,meas well as to ameliorate the inflammatory response in LPS-stimulated BV-2 cells.

   • According to QI R (2019)

     Excerpt Elephantopus scaber is a widely-used traditional herb whose use has been documented for various inflammatory diseases such as fever, sore throat, dysentery, carbuncle & so on. Aim: This study aims to investigate the anti-inflammatory mechanism of the ethanol extract of E.scaber (ESE) in lipopolysaccharide (LPS)-induced inflammatory models.

   • According to Ho WY (2011)

     Excerpt Recent studies had also suggested that this plant posses various bioactivities such as anti-bacterial, anti-inflammatory, hepatoprotective as well as anti cancer properties. Elephantopus scaber Linn, a herb from the Asteraceae family, has traditionally been taken as decoction or tea to cure various ailments & diseases throughout the world.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.