Epilobium parviflorum (Fireweed) : medicinal properties in alcoholic extraction

Epilobium parviflorum (Fireweed, Épilobe) — family Onagracées.

Scientific synonyms : Chamaenerion parviflorum-Schreb, Epilobium mollissimum-Schur, E pubescens-Roth, E rivulare-H, E uralense-H, E villosum-C.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 4 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 21 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for colorectal carcinoma

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to AKBUDAk A A (2002)

     Excerpt The present study exhibited the antiproliferative activity of aqueous & ethanolic Epilobium parviflorum extracts in a colon cancer cell line, HT-29 cells in vitro. Although their benefits have been demonstrated on certain types of cancer cells, such as prostate cancer cells, their potential antiproliferative effects on colorectal adenocarcinoma cells have yet to be studied.

   • According to Hatefi Kia B (2021)

     Excerpt Conclusion: This study is the first to demonstrate that Epilobium parviflorum had a strong growth inhibiting property on MCF-7 cell line, as a potential model to treat human breast cancer cells. Epilobium parviflorum extracts have shown promising therapeutic effects on prostate cancer cells.

   • According to Author (2019)

     Excerpt While reviewing the literature; we did not encounter any studies that practised the expression of apoptotic genes which is applied to the colon cancer cell line (HT29) & fibroblast cell line (BJ) of Epilobium parviflorum.

   • According to Stolarczyk M (2013)

     Excerpt Our studies demonstrated that the extracts from Epilobium angustifolium, Epilobium parviflorum & Epilobium hirsutum herbs are potent prostate cancer cells (LNCaP) proliferation inhibitors with IC50 values around 35 µg/ml. Results of the work offer an explanation of the activity of Epilobium extracts & support the use of Epilobium preparations in the treatment of prostate diseases.

   • According to Stolarczyk M (2013)

     Excerpt Conclusions: This study demonstrated that Epilobium extracts are active against LNCaP prostate cancer cells & that their apoptotic activity is related to activation of the mitochondrial pathway. The aim of this work was to determine the effect of standardized aqueous extracts from Epilobium angustifolium L., E.

2. 2

   Inflammatory conditions: osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hevesi BT (2009)

     Excerpt parviflorum with respect to its antioxidant and antiinflammatory effects. Epilobium parviflorum Schreb.

   • According to Granica S (2014)

     Excerpt were shown to possess antimicrobial, anti-proliferative, anti-inflammatory, analgesic & antioxidative activities. As far as the treatment of benign prostate hyperplasia (BPH) is considered, in the literature, there are some reports indicating that Epilobium extracts have a beneficial effect for this disorder, but the number of in vitro studies is not sufficient & the in vivo studies are not conclusive or too preliminary to draw a final conclusion about the efficacy of Epilobium preparations.

   • According to Merighi S (2021)

     Excerpt We investigated the phenolic content characterizing different plant extracts from Epilobium parviflorum, Cardiospermum halicacabum, & Melilotus officinalis, their antioxidant, antiinflammatory effects, & their mechanism of action. Conclusion: EP, CH, & MO extracts may be considered a source of agents for treating disorders related to oxidative stress & inflammation.

   • According to Hiermann A (1986)

     Excerpt Epilobium species have been used as remedies in folk-medicine for the treatment of pathophysiological processes of the prostata. angustifolium strongly reduced the carrageenin-induced rat paw oedema whereas that of E.

   • According to Tóth B Hevesi (2009)

     Excerpt Both the water & ethanol extracts of Hypoxis hemerocallidea & Epilobium parviflorum inhibited the growth of Escherichia coli. In vitro studies have been made to investigate different aspects of its antioxidant capacity, anti-inflammatory (COX-inhibitory) action, steroid-receptor -agonistic & -antagonistic effect as well as aromatase-inhibitory effect.

3. 3

   Benign prostatic hyperplasia

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to AKBUDAk A A (2002)

     Excerpt The Epilobium species are rich in various active phytochemicals & have seen wide use in folk medicine to treat several diseases, including benign prostatic hyperplasia. The present study exhibited the antiproliferative activity of aqueous & ethanolic Epilobium parviflorum extracts in a colon cancer cell line, HT-29 cells in vitro.

   • According to Vitalone A (n.d.)

     Excerpt This study examined whether various species of Epilobium, a phytotherapeutic agent used in folk medicine as a treatment for benign prostatic hyperplasia, may have an antiproliferative effect in PZ-HPV-7 human prostatic epithelial cells in-vitro. This study provides some initial biological plausibility for the use of Epilobium extracts in benign prostatic hyperplasia.

   • According to Hevesi BT (2009)

     Excerpt (Onagraceae) is used for the treatment of benign prostatic hyperplasia (BPH), but its biological action is not entirely identified. Epilobium parviflorum Schreb.

   • According to Vitalone A (n.d.)

     Excerpt We have previously shown that extracts of different Epilobium species, a phytotherapeutic agent used in folk medicine as a treatment for benign prostatic hyperplasia, inhibit proliferation of human prostate cells. These results indicate that Epilobium extracts inhibit proliferation of prostate cells in a nonspecific manner.

   • According to Tóth B Hevesi (2009)

     Excerpt Epilobium parviflorum is used for the treatment of benign prostatic hyperplasia (BPH), but its biological action is not entirely identified. -Abstract: Crude water & ethanolic extracts of five herbal remedies reported in the literature for traditional treatment of benign prostatic hyperplasia (BPH) and/or prostatitis were investigated for their effect on hydroxyl scavenging activity, antibacterial activity & their ability to inhibit cyclooxygenase-1 & -2 (COX-1 & COX-2) catalysed prostaglandin biosynthesis.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.