Eupatorium triplinerve (Djapanna) : medicinal properties in alcoholic extraction

Eupatorium triplinerve (Djapanna, Ayapana) — family Asteracées.

Scientific synonyms : Ayapana triplinervis-(Vahl) R.M. King & H. Robinson.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 83 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Suja G (2019)

     Excerpt The present study attempts to evaluate the phytochemical activity and in vitro anticancer activity of Eupatorium triplinerve methanol extract against lung cancer cell line A-549 & normal cell line Vero. In future, research need to be explored in the purification of this extract & identification of lead compound which could be used as a therapeutic tool against lung cancer.

   • According to Bepari M (2015)

     Excerpt After 24 h of the last dose, the antitumor effect of ethanolic & water extracts was assessed by evaluating tumor volume, viable cell count, increase in body weight, mean survival time & hematological parameters of the EAC bearing host. The objective of the present study is to explore the antitumour activity of the ethanolic & water extracts of the EA in Ehrlich Ascites Carcinoma (EAC) bearing Swiss albino mice.

   • According to Gayathri M (2023)

     Excerpt The primary objective of the present investigation is to evaluate the anti-hemorrhoidic, anti-inflammatory & anti-cancer potential of acetone leaf of Eupatorium triplinerve. Conclusion: The results revealed that the leaf extract possesses anti-cancer, anti-inflammatory and anti-hemorrhoidic properties at different concentration.

   • According to BOSE P (2007)

     Excerpt The present study was carried out to evaluate the hepatoprotective & antioxidant effect of the methanol extract of Eupatorium ayapana (MEEA) (Family- Asteraceae) leaves in Wistar albino rats. The MEEA nd silymarin produced significant (p < 0.05) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, uric acid, & lipid peroxidation and significantly (p < 0.05) increased the levels of SOD, CAT, GSH & protein in a dose dependent manner.

2. 2

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nadipelly J (2017)

     Excerpt To evaluate the anti-nociceptive activity of 7-methoxy coumarin isolated from ethyl acetate fraction of the alcoholic extract of Eupatorium triplinerve Vahl. Conclusion: A dose dependent anti-nociceptive action of 7- methoxy coumarin was revealed by the present experiments which support the traditional use of E.T in pain & inflammatory disorders.

   • According to Putri AS (2022)

     Excerpt In terms of cosmetic applications, the activities of Eupatorium are antioxidant, anti-tyrosinase, anti-melanin/melanogenesis, anti-acne, & anti-inflammatory. The active compounds of Eupatorium are contained in the whole plant, as well as the stems, leaves, roots, and aerial parts (flower, fruit, & seeds).

   • According to Gayathri M (2023)

     Excerpt The primary objective of the present investigation is to evaluate the anti-hemorrhoidic, anti-inflammatory & anti-cancer potential of acetone leaf of Eupatorium triplinerve. Materials & Methods: The acetone leaf extract was initially determined for in vitro cytotoxic potential against human colorectal adenocarcinoma cell line (HT-29) & to identify anti- inflammatory properties in macrophages (RAW 264.7 cells) through LPS stimulation with pro- inflammatory cytokines (IL-6 & TNF-α) expression study by flow cytometry.

   • According to Parimala K (2012)

     Excerpt The acute anti-inflammatory effect was studied by carrageenan induced hind paw edema method in rats. The present study indicates that the petroleum-ether extract of ET has potential antinociceptive & anti-inflammatory activity.

   • According to Leejae S (2015)

     Excerpt Leejae S et al, Eupatorium ayapana, a natural source of anti-biofilm, anti-inflammatory & anti-oxidant agents, Rangsit J of Arts & Sci, 5(2):141-9.

3. 3

   Pain, hyperalgesia

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to George M (2019)

     Excerpt Eupatorium triplinervis commonly known as ayapana is a most important plant used in traditional medicine. The present study indicates that the stem & root extracts of ET have potential analgesic activity.,.

   • According to Putri AS (2022)

     Excerpt Thus, it has pharmacological effects, including antifungal, antibacterial, cytotoxic, & antinociceptive properties, that can be utilized for cosmetic purposes. In terms of cosmetic applications, the activities of Eupatorium are antioxidant, anti-tyrosinase, anti-melanin/melanogenesis, anti-acne, & anti-inflammatory.

   • According to Melo AS (2013)

     Excerpt Eupatorium triplinerve Vahl belongs to the Asteraceae family, popularly known as Japana. The antinociceptive activity was verified using chemical (acetic acid & formalin) & thermal (hot plate) models of nociception.

   • According to Parimala K (2012)

     Excerpt Analgesic activity of petroleum-ether extract was evaluated by well-established models like acetic acid induced writhing, formalin test & tail immersion method in mice. The present study indicates that the petroleum-ether extract of ET has potential antinociceptive & anti-inflammatory activity.

   • According to Author (2017)

     Excerpt To evaluate the anti-nociceptive activity of 7-methoxy coumarin isolated from ethyl acetate fraction of the alcoholic extract of Eupatorium triplinerve Vahl. Conclusion: A dose dependent anti-nociceptive action of 7- methoxy coumarin was revealed by the present experiments which support the traditional use of ET in pain & inflammatory disorders.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.