Euphorbia milii (The Crown of Christ) : medicinal properties in alcoholic extraction

Euphorbia milii (The Crown of Christ, Couronne du Christ) — family Euphorbiacées.

Scientific synonyms : Euphorbia bojeri Hook., E bojeri Klotzsch, E rubrostriata Dr, Sterigmanthe bojeri (Hook.) Kloytzsch & Garcke, Tumalis bojeri (Hook.) Raf..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 5 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 58 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: chemoprevention

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to NGEM WA (2023)

     Excerpt Here, we elucidated the phytochemical profile of Euphorbia milii ethanol extract (EMEE) then, we studied its anti-inflammatory potential using a carrageenan-induced paw edema model in rats. Also, it was noticed the immunostaining with cyclooxygenase-2 & tumor necrosis factor-alpha antibodies decreased to a mild positive (score 1) after treatment with EMEE (200 mg/kg).

   • According to Delgado L (2003)

     Excerpt Euphorbia milii (Euphorbiaceae) is a decorative plant used in gardens and living fences. Two in vitro assays (inhibition of metabolic cooperation in V79 cells & Epstein-Barr virus induction in Raji cells) had suggested that EM latex contained tumor-promoting substances.

   • According to Ernst M (2015)

     Excerpt Fur- thermore the medicinally highly valuable subgenus Chamaesyce was identified as chemically under-investigated, emphasizing the need for further studies investigating the chemical diversity to which the high medicinal value of Euphorbia subg. Consensus ratios indicated that the most-valued medicinal uses of Euphorbia species are in the treatment of digestive & respiratory complaints, inflammation and injuries, especially by members of Euphorbia subg.

   • According to Riet K (2024)

     Excerpt Euphorbia milii,extract (EME), doxorubicin (Dox), & docetaxel (Doc) encapsulated in temperature–sensitive immunoliposomes were investigated for their activities against the prostate cancer LNCap & DU145 cell lines. The heat-sensitive immunoliposomes conjugated with a PSA antibody encapsulated the extract successfully & showed better cell antiproliferation efficacy against the prostate cancer cell lines in the presence of heat.

   • According to Agarwal S (2024)

     Excerpt This review summarizes the traditional uses, phytochemical profile, pharmacological activities, & therapeutic potential of Euphorbia milii, while also considering its toxicity profile,. Euphorbia milii, also known as the Crown of Thorns, is a plant with both ornamental and medicinal value, belonging to the Euphorbiaceae family.

2. 2

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Agarwal S (2024)

     Excerpt This review summarizes the traditional uses, phytochemical profile, pharmacological activities, & therapeutic potential of Euphorbia milii, while also considering its toxicity profile,. In vitro studies have demonstrated significant cytotoxic effects on cancer cell lines, while in vivo studies have supported its anti-inflammatory & antimicrobial effects.

   • According to NGEM WA (2023)

     Excerpt Here, we elucidated the phytochemical profile of Euphorbia milii ethanol extract (EMEE) then, we studied its anti-inflammatory potential using a carrageenan-induced paw edema model in rats. Interestingly, it resulted in a substantial increase (p < 0.05) in the levels of the anti-inflammatory interleukins (IL-10 & IL-12).

   • According to Salehi B (2019)

     Excerpt The extracts & secondary metabolites from Euphorbia plants may act as active principles of medicines for the treatment of many human ailments, mainly inflammation, cancer, & microbial infections. The chemical composition of essential oils from Euphorbia species revealed the presence of more than 80 phytochemicals, mainly oxygenated sesquiterpenes & sesquiterpenes hydrocarbons, while Euphorbia extracts contain secondary metabolites such as sesquiterpenes, diterpenes, sterols, flavonoids, & other polyphenols.

   • According to Delgado L (2003)

     Excerpt Euphorbia milii (Euphorbiaceae) is a decorative plant used in gardens and living fences. In China, it has also been employed in herbal remedies for hepatitis & abdominal edema.

   • According to Ernst M (2015)

     Excerpt Consensus ratios indicated that the most-valued medicinal uses of Euphorbia species are in the treatment of digestive & respiratory complaints, inflammation and injuries, especially by members of Euphorbia subg. Fur- thermore the medicinally highly valuable subgenus Chamaesyce was identified as chemically under-investigated, emphasizing the need for further studies investigating the chemical diversity to which the high medicinal value of Euphorbia subg.

3. 3

   Bacterial infection: Mycobacterium tuberculosis

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Satyaveni G (2014)

     Excerpt The present work will focus on the importance of plant base latex & their antifungal & antibacterial activity. There are about 7 indigenous Latex yielding plants were selected which are having diversified uses like medicinal, economic, timber & fibre yielding species like Calotropis gigantea (Jilledu), Carica papaya (papaya), Plumeria alba, Ficus religiosa (Ravi), Ficus bengalensis (Banyan), Euphorbia milli (crown of throns), Achras zapota (Sapota) viz.

   • According to TIWARI U (2023)

     Excerpt Euphorbia milii has been widely known as a remedy for skin infections, warts, cancer cells, hepatic disorders, fungal infections, nociceptive conditions, & viral infections. The present course of investigation represented notable medicinal applications of EM extract as an antiviral agent that would further be extended to molecular characterization & in silico antiviral action modeling to get depth insight.

   • According to Sundriyal S (2021)

     Excerpt Euphorbia hirta, Euphorbia milli & Euphorbia pulcherrima belong to the Euphorbia genus which is popular for its medicinal attributes in the folklore & cultural traditions countries in India, China, Pakistan & Brazil, etc. When observed for antimicrobial & antioxidant biological properties, all the three plants under evaluation depicted almost similar range of activity.

   • According to Agarwal S (2024)

     Excerpt This review summarizes the traditional uses, phytochemical profile, pharmacological activities, & therapeutic potential of Euphorbia milii, while also considering its toxicity profile,. Euphorbia milii, also known as the Crown of Thorns, is a plant with both ornamental and medicinal value, belonging to the Euphorbiaceae family.

   • According to Rauf AA (2014)

     Excerpt Rauf AA et al, Preliminary phytochemical screening, antimicrobial & antioxidant activities of Euphorbia milli.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.