Fragaria vesca (Milling cutter) : medicinal properties in alcoholic extraction

Fragaria vesca (Milling cutter, Frèz, Fraise) — family Rosacées.

Scientific synonyms : Dactylophyllum fragaria Spenn., F abnormis Tratt., F alpina (Weston) Steud., F chinensis Losinsk., F florentina Poit. & Turpin, Finsularis Rydb., F sylvestris (L.) Weston, F unifolia Steud..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 14 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 41 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Liberal JT (2013)

     Excerpt Previous studies performed in our laboratory demonstrated that a hydroalcoholic extract of Fragaria vesca leaves affects cellular proteolytic pathways through the reduction of proteasome activity& modulation of autophagic machinery, mechanisms that are therapeutic targets in cancer treatment. Thus, the aim of this study was to evaluate the anti-cancer properties of an ellagitannin-enriched fraction (EEF) from FV leaves (characterized by HPLC/PDA/ESI-MSn), in human hepatocellular carcinoma cells (HepG2).

   • According to Cardoso O (2018)

     Excerpt (Ag), Fragaria vesca (Fv) extracts & a Fv ellagitannin-enriched fraction (Fve) activity were tested against these isolates. Helicobacter pylori plays a causal role in chronic gastritis, peptic ulcer & gastric cancer.

   • According to Liberal JT (2014)

     Excerpt Fragaria vesca leaves have been used in folk medicine for the treatment of several diseases, namely gastrointestinal, cardiovascular & urinary disorders, which could be related with the potential anti-inflammatory properties of the extract. Polyphenols, namely ellagitannins, proanthocyanidins, & quercetin & kaempferol glucuronide derivatives were identified in Fragaria vesca leaves extract.

   • According to Kirsch J (2020)

     Excerpt The present in situ study aims to examine the influence of the polyphenolic tea drugs Fragaria vesca, hamamelis & tormentil on the initial oral bio adhesion. After 1 min of intraoral pellicle formation, the subjects rinsed with Fragaria vesca, tormentil (0.8 mg/8 mL) & hamamelis (0.2 mg/8 mL) for 10 min.

2. 2

   Irritable bowel syndrome

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kanodia L (2011)

     Excerpt Ethanolic extract of Fragaria vesca (EFFV) fruits was prepared by percolation method & subjected to oral toxicity testing using OECD guidelines. EFFV at 500 mg/kg showed significant amelioration of experimentally induced IBD, which may be attributed to its antioxidant & anti-inflammatory properties.

   • According to Liberal JT (2014)

     Excerpt Fragaria vesca leaves have been used in folk medicine for the treatment of several diseases, namely gastrointestinal, cardiovascular & urinary disorders, which could be related with the potential anti-inflammatory properties of the extract. Materials & methods: A hydroalcoholic extract was prepared from FV leaves & its anti-inflammatory potential was evaluated through inhibition of nitric oxideproduction and expression of several pro-inflammatory proteins in lipopolysaccharide-triggered macrophages.

   • According to Malheiros J (2022)

     Excerpt (wild strawberry) is traditionally used for its anti-inflammatory activity and for gastrointestinal, cardiovascular & urinary disorders.

   • According to Liberal JT (2013)

     Excerpt Previous studies performed in our laboratory demonstrated that a hydroalcoholic extract of Fragaria vesca leaves affects cellular proteolytic pathways through the reduction of proteasome activity& modulation of autophagic machinery, mechanisms that are therapeutic targets in cancer treatment. Thus, the aim of this study was to evaluate the anti-cancer properties of an ellagitannin-enriched fraction (EEF) from FV leaves (characterized by HPLC/PDA/ESI-MSn), in human hepatocellular carcinoma cells (HepG2).

   • According to Dhole AR (2020)

     Excerpt In vitro experiments (nucleation, aggregation & microscopic assay's) were performed to test the anti-urolithiasis activity of microwave assisted extracted CP, FV & BS extracts. Results: The extracts were tested for the inhibition percentage of anti-urolithiasis potential against preformed calcium oxalate crystal.

3. 3

   Pain, peripheral hyperalgesia

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kanodia L (2009)

     Excerpt The aim of the study was to compare the analgesic activities of ethanolic extract of fruits & whole plant of Fragaria vesca in experimental animal models. Fruit extract, whole plant extract & aspirin showed significant analgesic activity, both central & peripheral, as compared to control (p<0.01).

   • According to Kanodia L (2008)

     Excerpt The aim of the study was to compare the analgesic activities of ethanolic extract of fruits and whole plant of Fragaria vesca in experimental animal models. Fruit extract, whole plant extract & aspirin showed significant analgesic activity, both central & peripheral, as compared to control (p<0.01).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.