Graptophyllum pictum (Karikati) : medicinal properties in alcoholic extraction

Graptophyllum pictum (Karikati, Lèt-lavièj, Caricature, Virgin’s milk, lait de la Vierge) — family Acanthacées.

Scientific synonyms : Graptophyllum nortonii Van Geert, G picturatum W.Bull, G versicolor Veitch ex J.Dix, Justicia klotzschiana Hoffm. ex Nees, J nitida Nees, Jcarayana F.Newman ex Nees, J picta L., Marama picta (L.) Raf..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 64 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Rahmi H (2014)

     Excerpt Wungu leaf (Graptophyllum pictum (L.) Griff) is a plant thought to have potential use in alleviating symptoms of diabetes mellitus. The purpose of the present study was to evaluate the activity of wungu leaf extracts in decreasing blood glucose level of alloxan (200 mg/kg BW)-induced hyperglycemic mice.

   • According to Author (2010)

     Excerpt This study was aimed at evaluating the claimed anti-diabetic property of the aqueous extract of Graptophyllum pictum leaf & to establish an effective dose for the extract. The anti-diabetic study was carried out on alloxan-induced diabetic Wistar rats.

   • According to Metiefeng NT (2023)

     Excerpt Graptophyllum pictum is a tropical plant noticeable for its variegated leaves & exploited for various medicinal purposes. The compounds were evaluated for their anticholinesterase activities against acetylcholinesterase (AChE) & butyrylcholinesterase (BchE), as well as their antidiabetic potential through inhibition of α-glucosidase & α-amylase.

   • According to Priyanto JA (2024)

     Excerpt pictum leaves was a potential source of therapeutic compounds, particularly for antioxidant, antidiabetic, anticancer, & antibacterial agents. Graptophyllum pictum (L.) Griff is a medicinal shrub belonging to the Acanthaceae family & is traditionally used to treat various diseases.

   • According to Makkiyah F (2021)

     Excerpt Graptophyllum pictum (L.) Griff., a shrubby stove plant, has been used traditionally to treat various diseases. Meanwhile, the pharmacological analysis revealed that this plant possessed various activities such as antimicrobial, immunomodulatory, antioxidant, anti-inflammation, anti-analgetic, wound- healing, anti-hemorrhoid, anti-diabetic, & estrogenic effects.

2. 2

   Dental caries, periodontitis: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis & Streptococcus mutans

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Syahrani N (2024)

     Excerpt Purple leaf (Graptophyllum pictum) is one of the medicinal plants or natural ingredients that are useful as antibacterial. mutans would prevent the risk of dental caries.

   • According to Kusumaningsih T (2015)

     Excerpt streptococcus mutans are the main cause of dental caries bacteria. purle leaf (Graptophyllum pictum (L) Griff) is one of traditional medicinal plants which contains flavonoid, alkaloid, saponin & tannin that has antimicrobial effect.

   • According to Dhynawanda DE (2023)

     Excerpt Conclusion: GPL can be used for medical & dental purposes due to its anti-inflammatory, antioxidant, antibacterial, & antifungal properties. Review(s): Based on the 36 articles included, GPL is widely used in medicine & dentistry, such as for treatment of hemorrhoids, periodontitis, & candidiasis, due to its anti-inflammatory, antioxidant, & antifungal properties.

   • According to Author (2017)

     Excerpt The ungu leaf (Graptophyllum pictum (L.) Griff.) Can traditionally relieve hemorrhoid symptoms. This research was aimed to find out the antifungal activity of n-hexane, ethyl acetate & water fraction of ethanolic extract of ungu leaves on Candida albicans ATCC 10231.

   • According to Arista RA (2023)

     Excerpt Indonesia boasts a rich array of medicinal herbs, including the wungu (Graptophyllum pictum L. However, the antibacterial assays strikingly showed efficacy against bacteria across all parts of the plants, with varying strengths from weak to strong.

3. 3

   Menopause: endometrial hyperplasia, menstrual irregularities, prevention of osteoporosis in postmenopausal women, palliative treatment of prostate cancer

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Amin A (2020)

     Excerpt One of the plants that potential to develop as an anticancer agent is daun ungu (Graptophyllum Pictum (L.) Griff). The purpose of this study was to determine the cytotoxic activity of G.P ethanolic extract & its fractions on human colon cancer WiDr cells & to elucidate the compounds contained in most active extracts/ fractions.

   • According to Jiangseubchatveera N (2015)

     Excerpt The essential oil from the leaves of Graptophyllum pictum (L.) Griff. The oil showed significant cytotoxicity against KB (epidermoid carcinoma of oral cavity), NCI-H187 (small cell lung carcinoma) & Vero cell lines with IC50 values of 27.04, 25.27 & 26.52 µg/mL, respectively.

   • According to Suhargo L (2018)

     Excerpt Endometrial & myometrial hyperplasia was caused as a side effect of estradiol hormone using for menopausal condition & it could change to be cancer. The aim of this research was conducted to evaluate the utilization of daun wungu ethanol extracts as the endometrial & myometrial hyperplasia inhibitor of ovariectomy mice.

   • According to Rakasiwi HL (2019)

     Excerpt Menopause can occur osteoporosis caused by low estrogen. pictum leaf extract has no effect on bone morphometry but can increase the calcium content of the femur.

   • According to Priyanto JA (2024)

     Excerpt pictum leaves was a potential source of therapeutic compounds, particularly for antioxidant, antidiabetic, anticancer, & antibacterial agents. Graptophyllum pictum (L.) Griff is a medicinal shrub belonging to the Acanthaceae family & is traditionally used to treat various diseases.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.