Gynandropsis gynandra (White Akaya) : medicinal properties in alcoholic extraction

Gynandropsis gynandra (White Akaya, White Mouzambé, Spicy, White Acaya, Akaya-blan, Mouzambé-Blan, Pimanté, Acaya blanc, Mouzambé blanc, Pimenté) — family Capparacées.

Scientific synonyms : Cleome gynandra-L, gynandropsis pentaphylla-L-DC.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 15 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 109 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Dhandayuthapani S (2019)

     Excerpt A significant increase (p<0.001) in the activities of cancer marker enzymes γ-GT, LDH, ALP & 5| -NT in serum, liver & kidney with a significant elevation in the serum transaminases with a concomitant decrease in the liver & kidney transaminases activities in AFB1-induced HCC bearing rats were observed when compared with the normal control rats. These results indicate that GG extract could potentially modulate the cancer marker enzymes & thus could elicit suppressive activity on tumour growth in AFB1-induced male albino rats.

   • According to Sivanesan D (2007)

     Excerpt aerial parts extract on aflatoxin B1 (AFB1)-induced hepatocellular carcinoma (HCC) was studied on glucose-metabolizing enzymes in rats. In the present study, the effect of Gynandropsis gynandra L.

   • According to Dhandayuthapani S (n.d.)

     Excerpt extract on aflatoxin B1 (AFB1)-induced hepatocellular carcinoma (HCC) was studied on glucose-metabolizing enzymes in rats. In the present study, the effect of Gynandropsis gynandra L.

   • According to Chand J (2021)

     Excerpt The different parts of the plants, such as leaves, seeds, flowers, & roots, are used to treat acute & chronic inflammatory disorders, hepatotoxicity, malaria, fungal diseases, & cancer. Results & conclusion :Investigations & current evidence revealed that the different chemical constituents present in cleome species possess various health-promoting effects along with the aerial parts showing promising traditional uses in traditional healing & culinary.

   • According to SHAIK K (2013)

     Excerpt The objective of the present study was to investigate the hypoglycemic effect of Cleome gynandra L Ethanolic leaf extract (EECG) on normal & non insulin dependent diabetes mellitus in rats. The study was further carried out to investigate the effect of extract on blood glucose & hepatic enzyme level.

2. 2

   Type II diabetes mellitus

   Plant part used: Sheet. Mentioned synergistic association: Amaranthus cruentus-feuille.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Siwale DR (2019)

     Excerpt Objective: The present study was conducted to assess blood glucose lowering effects of ethanolic leaf extracts of Cleome gynandra (CG), Amaranthus cruentus (AC) & their mixture (1:1 ratio) in Normoglycaemic & Alloxan-diabetic rats. However, abnormally high blood glucose is characteristic of Diabetes Mellitus (DM) due to defects in insulin secretion, insulin action or both.

   • According to SHAIK K (2013)

     Excerpt The objective of the present study was to investigate the hypoglycemic effect of Cleome gynandra L Ethanolic leaf extract (EECG) on normal & non insulin dependent diabetes mellitus in rats. The results revealed the beneficial role of EECG as a potential hypoglycemic gent against Alloxon induced diabetes mellitus in rats.

   • According to Ravichandra B (2014)

     Excerpt The study aim is to investigate the Anti diabetic an anti dyslipidemic activity of Cleome gynandra plant extract in alloxan-induced diabetic rats. The CG was significantly (p<0.05) reduced the serum glucose, elevated dyslipidemia levels, SGOT & SGPT levels, in alloxan induced group, Metformin treated group, EECG-I group, EECG-II groups but increased the serum HDL status in all the ethanolic extract CG treated groups, compared with normal control & diabetic control.

   • According to Trilochana Y (2017)

     Excerpt It has been planned to explore the hypoglycaemic & antihyperglycaemic activity of aqueous extract of root of Gynandropsis gynandra herb in normal & diabetic rats. The study revealed that the GG herb was found to have hypoglycemic actions compared with Tolbutamide.

   • According to Adhikari PP (2018)

     Excerpt Careful scrutiny reveals that the plant possesses a huge range pharmacological applications, such as anti-inflammatory, free radical scavenging, anticancerous, immunomodulator, & antidiabetic agents.

3. 3

   Aflatoxin-induced hepatotoxicity

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Dhandayuthapani S (2019)

     Excerpt Gynandropsis gynandra L., has been reported to be useful in treatment of various ailments in the Indian system of medicine. We proposed to investigate the biopotency of GG extract against aflatoxin B1-induced hepatocellular carcinoma in rats.

   • According to Sivanesan D (2007)

     Excerpt aerial parts extract on aflatoxin B1 (AFB1)-induced hepatocellular carcinoma (HCC) was studied on glucose-metabolizing enzymes in rats. In the present study, the effect of Gynandropsis gynandra L.

   • According to Dhandayuthapani S (n.d.)

     Excerpt extract on aflatoxin B1 (AFB1)-induced hepatocellular carcinoma (HCC) was studied on glucose-metabolizing enzymes in rats. In the present study, the effect of Gynandropsis gynandra L.

   • According to Tejaswini K (2015)

     Excerpt Tejaswini K et al, Hepatoprotective Activity of Methanolic Extract of Cleome gynandra Leaves against CCl4-Induced Hepatotoxicity in Rats Inter J of Innovative Pharmaceut Sci & Res, 2015; 3(1): 85-90-.

   • According to SHAIK K (2013)

     Excerpt The objective of the present study was to investigate the hypoglycemic effect of Cleome gynandra L Ethanolic leaf extract (EECG) on normal & non insulin dependent diabetes mellitus in rats. The study was further carried out to investigate the effect of extract on blood glucose & hepatic enzyme level.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.