Hylocereus polyrhizus (Red pitaya) : medicinal properties in alcoholic extraction

Hylocereus polyrhizus (Red pitaya, Pitaya wouj, Pitaya rouge) — family CaCTacée.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 89 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Alcohol addiction, fatty liver disease

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Thadeus SM (2018)

     Excerpt This study aims to prove that the administration of Hylocereus polyrhizus has an effect on membrane lipid peroxidation & liver tissue damage triggered by hyperlipidemia in white rats (Rattus norvegicus). HP extract 60 mg/day has a potential effect in repairing lipid peroxidation damage on liver cell membrane in hyperlipidemia conditions with high fat diet.

   • According to Ariffin A.A. (2009)

     Excerpt Hylocereus undatus & Hylocereus polyrhizus are two varieties of the commonly called pitaya fruits.

   • According to Yeh W (2020)

     Excerpt PPE treatment significantly ameliorated liver injury & hepatic fat accumulation, & it improved hepatic lipid metabolism via increases in AMPK & PPAR-α protein expression & a decrease in SREBP-1 expression. Hylocereus polyrhizus peel is rich in polyphenols & betanins, which possess antioxidative & anti-inflammatory properties.

   • According to Macia-Ceja D (2018)

     Excerpt We aim to determine the effects of the flesh ethanolic extract of H polyrhizus in a mice model of colitis induced by TNBS.Balb/c mice received TNBS (175 mg/kg, 100 μl, i.r.) & six & thirty hours later were administered with EH (1 g/kg, i.p.).

   • According to Mihir Y.P (2019)

     Excerpt Mihir Y.P et al, Antioxidant & hepatoprotective potential of dragon fruit extract in 003 opposition to acetaminophen-induce liver smash up in rats, Adv.

2. 2

   Colitis

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Macia-Ceja D (2018)

     Excerpt The LC–MS analysis detected metabolites such as polyphenols & fatty acids.Systemic administration of the ethanolic extract of HP exerts an anti-inflammatory effect & prevents murine colitis induced by TNBS. We aim to determine the effects of the flesh ethanolic extract of H polyrhizus in a mice model of colitis induced by TNBS.Balb/c mice received TNBS (175 mg/kg, 100 μl, i.r.) & six & thirty hours later were administered with EH (1 g/kg, i.p.).

   • According to Yeh W (2020)

     Excerpt Hylocereus polyrhizus peel is rich in polyphenols & betanins, which possess antioxidative & anti-inflammatory properties. In addition, PPE inhibited CYP2E1 & Nrf2 protein expression, reduced endotoxin levels in the serum, & decreased TLR4 & MyD88 expression & inflammatory cytokine TNF-α & IL-1β levels in the liver.

   • According to Rodriguez E.B (2016)

     Excerpt Duck embryo chorioallantoic membrane (CAM) vascular irritation assay showed that the anti-inflammatory activity of encapsulated betalains was five- to six-fold higher than that of non-encapsulated betalains (P ≤ 0.05). This study aimed to evaluate the health-promoting bioactivities of betalains from Hylocereus polyrhizus peels as affected by encapsulation in maltodextrin–gum Arabic & maltodextrin–pectin matrices.

   • According to Tahir T (2021)

     Excerpt This study aims to identify the effect of Hylocereus polyrhizus on the level of VEGFs and TGF-β1 in acute Wistar rat wounds. This study has shown that HP can accelerate wound healing during both the inflammation & proliferation phase,.

   • According to Rahmawati M.A (n.d.)

     Excerpt Results: Hemoglobin level in the intervention group (mean= 11.27; SD= 0.85) was higher than control group (mean= 10.34; SD= 0.94) & it was statistically significant (p<0.001). Hematocrit level in the intervention group (mean= 36.78; SD= 3.17) was higher than control group (mean= 34.98; SD= 2.32) & it was statistically significant (p<0.001).

3. 3

   Dyslipidaemia: hypercholesterolaemia, hypertriglyceridaemia, hyperlipidaemia, low HDL

   Plant part used: Fruit. Mentioned synergistic association: Allium sativum-bulbe.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Omidizadeh A (2014)

     Excerpt This study investigated the anti-insulin resistant activity of red pitaya (Hylocereus polyrhizus) fruit. Thermally-treated pitaya at 105 °C for 60 min (containing a low antioxidant & soluble dietary fiber content) fed to rats had no significant effect on insulin resistance, dyslipidemia & atherogenesis.

   • According to Aisah WS (2019)

     Excerpt garlic extract (Allium sativum) & red dragon fruit extract (Hylocereus polyrhizus) have been used to improve lipid profile. Objective: to determine the effectiveness between garlic, red dragon extracts,&d its combination on lipid profile and number of foam cells.

   • According to Indriasari I (2012)

     Excerpt Indriasari I et al, Ethanol Extract of Red Dragon Fruit (Hylocereus polyrhizus) Improves Lipid Profile in Dyslipidemia Male Wistar Rats (Rattus norvegicus), Udayana University.

   • According to Khalili MA (2009)

     Excerpt Khalili MA et al, Hypocholesterolemic effect of red pitaya (Hylocereus sp.), on hypercholesterolemia induced rats, Inter Food Res J, (16): 431-40.

   • According to Thadeus SM (2018)

     Excerpt This study aims to prove that the administration of Hylocereus polyrhizus has an effect on membrane lipid peroxidation & liver tissue damage triggered by hyperlipidemia in white rats (Rattus norvegicus). HP extract 60 mg/day has a potential effect in repairing lipid peroxidation damage on liver cell membrane in hyperlipidemia conditions with high fat diet.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.