Hylocereus undatus (Pitaya) : medicinal properties in alcoholic extraction

Hylocereus undatus (Pitaya, dragon fruit, fruit du dragon) — family Cactacées.

Scientific synonyms : Cereus tricostatus Rol.-Goss, C undatus Pfeiff., Hylocereus guatemaensis (Eichlam.) Britton & Rose, H tricostatus (Goss.) Britton & Rose.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 6 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 65 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of hormone-dependent and hormone-independent breast cancer

   Plant part used: Fruit (flesh).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Uribe Calvillo T (2013)

     Excerpt So, this results demonstrate the capaticy of Hylocereus undatus compounds to diminished cell survival on cervix cancer in vitro e in vivo,. Alamar Blue assay was used to study the antiproliferative activity of Hylocereus extract on cervix cancer cell line HeLa (PVH-18).

   • According to Salam HS (2022)

     Excerpt This research aimed to analyze the phytochemical components of Hylocereus undatus pulp & peel extracts using LC-MS and GC-MS, and to investigate the in vitro effects of both extracts against cancer (breast, MCF-7, & colon, Caco-2) & normal (lung; WI-38 & breast; MCF-10A) cell proliferation using the MTT assay. Both extracts displayed cytotoxic activity against MCF-7 & Caco-2 cancer cells after 48 h of treatment at IC50 values ranging from 14 to 53 μg/mL with high selective indices against normal WI-38 & MCF-10A cell lines.

   • According to Paśko P (2021)

     Excerpt Direct comparisons of antioxidant & cytotoxic properties of the methanol & water extracts of the fruits, with the range of antioxidant tests (ABTS, CUPRAC, DPPH & FRAP) & also with normal (HaCaT & PNT2) & cancer (A375, WM793, Du145, HepG2, Caco-2, HT-29 & A549) cell lines was done. Pitaya or dragon fruit comprises a group of exotic cacti species of the genus Hylocereus, with characteristic, eye-catching fruits.

   • According to Jimenez-Garcia SN (2022)

     Excerpt Studies indicate that the pulp has vitamin C & betalains, & seeds are rich in essential fatty acids, compounds that can contribute to the prevention of chronic non-communicable diseases (cancer, hypertension, & diabetes). undatus had higher antioxidant activity with 51% related to the presence of flavonoids 357 mgRE/g sample and fatty acids (hexadecanoic acid & linoleate) with 0.310 & 0.248 mg AG/g sample, respectively.

2. 2

   Bacterial infection: S. aureus, E. coli, S. typhimurium and K. pneumoniae

   Plant part used: Fruit (flesh).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2019)

     Excerpt Evaluation of the in vitro antioxidant & antimicrobial activity from extract of Hylocereus undatus fruit pulp & peel extracts. Thus, this study reveals that H undatus fruit pulp & peel extract has phytochemical compounds which showed antimicrobial activity & can be used as natural antioxidant.

   • According to Nurmahani M (2012)

     Excerpt In this study, the antibacterial activity of ethanol, chloroform & hexane extracts from Hylocereus polyrhizus (red flesh pitaya) & Hylocereus undatus (white flesh pitaya) peels against nine pathogens was evaluated using disc diffusion method & broth micro-dilution method. undatus peel were found to exhibit good antibacterial activity where almost all the pathogens studied were successfully inhibited.

   • According to Naseer U (2012)

     Excerpt Naseer U et al, Evaluation of antibacterial activity of five selected fruits on bacterial wound isolates.

   • According to Ranon N (2008)

     Excerpt The study was aimed at evaluating the inhibitory property of Hylocereus undatus (Red Dragon Fruit) extract against Salmonella typhimurium grown on Salmonella-Shigella Agar. These findings suggest the inhibitory effect of HU Fruit extract against Salmonella which may prove useful in isolating all other organisms of interest aside from Salmonella typhimurium.

3. 3

   Constipation

   Plant part used: Fruit (flesh).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kanchana P (2018)

     Excerpt HU extract was found to increase the number of faecal matter, faecal weight & decrease in the water content of faeces which were indication of laxative activity of HU Conclusion: The result of the study shows the Antiparkinson’s & Constipation activity of H undatus. To evaluate the antiparkinson’s & constipation activity of Hylocereus undatus fruit extract in haloperidol induced parkinson’s disease & loperamide induced constipation in mice.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.