Illicium verum (Lanni étwalé) : medicinal properties in alcoholic extraction

Illicium verum (Lanni étwalé, Star anise, Chinese badamier, Anis étoilé, Badamier de Chine) — family Schisandracées.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 4 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 43 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of colorectal carcinoma, breast cancer, sarcoma, promyelocytic leukaemia, liposarcoma, synovial sarcoma, osteosarcoma, melanoma and leiomyosarcoma

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lombardi WRM (2017)

     Excerpt Methods: The human liposarcoma cell line (SW872), the human synovial sarcoma cell line (SW982), the human bone osteosarcoma cell line (HS 39.T), the human connective tissue leiomyosarcoma cell line (HS 5.T), the human acute promyelocytic leukemia cell line (HL-60), the human melanoma cell line (M14WM), the human breast adenocarcinoma cell line (MCF-7), & the human colon carcinoma (HT29) cell lines were purchased from American Type Culture Collection (Rockville, MD). Results: Experimental results obtained through a variety of methods & techniques indicated that extracts of Ilicium verum, Glycyrhizza glabra, Rhamnus frangula & Linum usitatissimum present significant reduction in in vitro tumor cell proliferation, suggesting these extracts as possible chemotherapeutical adjuvants for different cancer treatments.

   • According to Kausar R (2017)

     Excerpt The present study was used to design to cure cancers by the treatment of Chinese star anise (illicium verum) extraction (not Japanese star anise) & vegetables (Leaf Turnip) in relation with vit.C antioxidant activity. Thus, the aim of the study is to enhance the function of star anise or iV as an anticancer agent.

   • According to Khan M (2022)

     Excerpt Major bioactive compounds of ASF & their extracts have proven to be effective against GC due to the mechanistic action of these compounds involving signaling pathways that target cancer cell apoptosis, proliferation, & tumor metastasis in GC cells. Anisi stellati fructus (ASF) is the fruit of Illicium verum Hook F.

   • According to Sung YY (2012)

     Excerpt Illicium verum is a traditional herbal medicine with anti-inflammatory properties used in Asia. In addition, we determined the expression of IL-4, IL-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ thymus- & activation-regulated chemokine (TARC), regulated on activation, normal T cell expressed & secreted (RANTES), ICAM-1, & vascular cell adhesion molecule (VCAM)-1 in ear tissues.

   • According to Sung YY (2012)

     Excerpt Illicium verum is a traditional herbal medicine with anti-inflammatory properties used in Asia. In addition, we determined the expression of IL-4, IL-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ thymus- & activation-regulated chemokine (TARC), regulated on activation, normal T cell expressed & secreted (RANTES), ICAM-1, & vascular cell adhesion molecule (VCAM)-1 in ear tissues.

2. 2

   Atherosclerosis, hyperlipidaemia

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Park SH (2015)

     Excerpt Illicium verum Hook. The aortic expression of inflammatory adhesion molecules & cytokines (TNF-α, IL-1β, NF-κB, COX, IκB-α, Iκκ-α/β), which is characteristic of HFD-fed ApoE−/− mice, was attenuated by 12-week treatment with daily oral administration of Illicium v.

   • According to Bhadra S (2011)

     Excerpt Illicium verum is a well-known spice in traditional Indian system for its therapeutic potential. Therefore IV can be a good lead as anti-cholinesterase agent from natural resources.

   • According to Sharafan M (2022)

     Excerpt Illicium verum Hook f. Recent pharmacological studies on fruit extracts & the essential oil of this species have confirmed their antibacterial, antifungal, anti-inflammatory, & antioxidant activities & thus their medicinal & cosmetic value.

   • According to Khan M (2022)

     Excerpt Anisi stellati fructus (ASF) is the fruit of Illicium verum Hook F. The present review aims to discuss the bioactive properties of ASF & its phytocompounds against GC, with a particular insight into the molecular mechanisms & signaling pathways involved in its anti-GC mechanism.

   • According to Kim YS (2019)

     Excerpt Anisi stellati fructus (ASF) is the dried fruit of the Illicium verum Hook.f. The anti-p210Bcr-Abl effects of ASFE & ASFE + IM combination were evaluated by western blotting.

3. 3

   Atopic dermatitis: skin laceration, thin ear

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sung YY (2012)

     Excerpt Conclusions :These results indicate that IVE inhibits atopic dermatitis-like skin lesions by suppressing the expression of cytokines, chemokines, & adhesion molecules. verum extract (IVE) in a mouse model of atopic dermatitis.

   • According to Sung YY (2012)

     Excerpt Conclusions: These results indicate that IVE inhibits atopic dermatitis-like skin lesions by suppressing the expression of cytokines, chemokines, & adhesion molecules. This study evaluated the anti-inflammatory & antiallergic effects of IV extract (IVE) in a mouse model of atopic dermatitis.

   • According to Park SH (2015)

     Excerpt Illiciaceae (Illicium v.) has been traditionally used in herbal medicine for treating many inflammatory diseases, including skin inflammation & rheumatism. Illicium verum Hook.

   • According to Sung YY (2012)

     Excerpt Conclusions: IVE exerts anti-inflammatory effects by suppressing the expression of TNF-α/IFN-γ-induced chemokines, pro-inflammatory cytokines, & adhesion molecules via blockade of NF-κB, STAT1, MAPK, & Akt activation, suggesting that IVE may be a useful therapeutic candidate for inflammatory skin diseases, such as atopic dermatitis,. This study investigated the anti-inflammatory effects of Illicium verum extract (IVE) in the human keratinocyte HaCaT cell line.

   • According to Kim JY (2009)

     Excerpt In order to determine whether IAE can be safely applied to human skin, the cytotoxic effects of IAE were determined by colorimetric MTT assays in human dermal fibroblast & keratinocyte HaCaT cells. The essential oil of air-dried Illicium anisatum (Illiciaceae), obtained by hydrodistillation was analyzed by gas chromatography-mass spectrometry (GC-MS).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.