Indigofera tinctoria (Digo) : medicinal properties in alcoholic extraction
Indigofera tinctoria (Digo, Indigo) — family Fabacées.
Scientific synonyms : Anila tinctoria (L.) Kuntze, Indigofera bergii Vatke, I cinerascens DC, I houer Forssk., I indica Lam., I oligophylla Baker, I orthocarpa (DC.) O.Berg & C.F.Schmidt, I sumatrana Gaertn, I tinctoria Blanco, I tulearensis-Drake.
This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 51 scientific references for this species (full detail in the application).
Therapeutic indications in alcoholic extraction:
Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).
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Diabetic nephropathy
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Bangar AV (2011)
Excerpt The objective of the present study was to investigate anti-diabetic & nephroprotective activity of Indigofera tinctoria leaves, using STZ-induced diabetic rats as model for clinical type-1, type-2 diabetes. IT leaves extract improved renal creatinine clearance & reduce renal total protein loss demonstrating nephroprotective properties.
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According to Verma SM (2009)
Excerpt The methanolic extract of dried leaves of Indigofera tinctoria Linn showed significant decrease in blood glucose level of rabbits as estimated by Folin-Wu Method. In this experiment, alloxan is used as diabetes inducing agent.
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According to PRIYADARSINI G (2012)
Excerpt PRIYADARSINI G et al, NEPHROPROTECTIVE ACTIVITY OF DECOCTION OF INDIGOFERA TINCTORIA (AVURI KUDINEER) AGAINST CISPLATIN-INDUCED NEPHROPATHY IN RATS, Inter J of Life Sci & Pharm Res, 2, 2012,.
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According to Anand K (1981)
Excerpt Anand K et al, Histological evidence of protection by Indigofera tinctoria Linn.
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According to Malarvannan L (2003)
Excerpt The effects of pre-treatment with alcoholic extract of Indigofera tinctoria Linn (Leguminosae) (500 mg/kg body wt/day orally for 21 days) on liver antioxidant defense system during acute hepatitis induced by D-galactosamine (D-GalN) /endotoxin (LPS extracted by phenol water method from E. IT pre-treated rats showed considerable protection against D-GalN/endotoxin-induced oxidative stress as evidenced by a significant increase in the activities of all the antioxidant enzymes studied & significant decrease in the levels of lipid peroxides.
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According to Bangar AV (2011)
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Type II diabetes mellitus
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Bangar AV (2011)
Excerpt The objective of the present study was to investigate anti-diabetic & nephroprotective activity of Indigofera tinctoria leaves, using STZ-induced diabetic rats as model for clinical type-1, type-2 diabetes. Statistical analysis of the results shown that in STZ-induced diabetic rats chloroform & alcohol extracts of IT leaves at 40, 80, 160 & 200 mg/kg doses.
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According to Verma SM (2009)
Excerpt The methanolic extract of dried leaves of Indigofera tinctoria Linn showed significant decrease in blood glucose level of rabbits as estimated by Folin-Wu Method. In this experiment, alloxan is used as diabetes inducing agent.
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According to Bangar AV (2011)
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Type 1 diabetes mellitus
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Bangar AV (2011)
Excerpt The objective of the present study was to investigate anti-diabetic & nephroprotective activity of Indigofera tinctoria leaves, using STZ-induced diabetic rats as model for clinical type-1, type-2 diabetes. Statistical analysis of the results shown that in STZ-induced diabetic rats chloroform & alcohol extracts of IT leaves at 40, 80, 160 & 200 mg/kg doses.
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According to Verma SM (2009)
Excerpt The methanolic extract of dried leaves of Indigofera tinctoria Linn showed significant decrease in blood glucose level of rabbits as estimated by Folin-Wu Method. In this experiment, alloxan is used as diabetes inducing agent.
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According to Bangar AV (2011)
Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.
Evolution of this plant record
Under the CTA · public change history
~2 indications corrected · ~3 references corrected
Counts and domains only: indication labels and synergy names are not listed here (open the in-app plant file). Bibliographic texts for new, corrected, or removed references expand below.
~3 references corrected — show text
Brouillet E, Nitro propionic acid, Encyclopedia of Movement Disorders, 2010-Abstract: The neurotoxin 3-nitropropionic acid (3NP), a metabolite of 3-nitropropanol, was identified many decades ago in western United States of America as a toxic agent responsible for livestock poisoning. Animals intoxicated with leguminous plants (e.g., Indigofera or Astragalus) presented motor abnormalities consisting of general weakness & incoordination of the hindlimbs that evolved to paralysis.
CorrectedGaboriaud-Kolar N et al, Indirubin derivatives: a patent review (2010 - present), Expert Opin Ther Pat, 25(5) :583-93, 2015-Abstract: Indirubins are bisindole alkaloids naturally occurring in indigo-bearing plants or in mollusks from the Muricidae family. They belong to the rather small family of indigoids, which has nevertheless found an extreme importance in the fields of dyes & medicinal chemistry. Indirubin has been found to be the active ingredient of a traditional Chinese Medicine used to treat the symptoms of leukemia. Further biological explorations revealed the ability of indirubin…
CorrectedBlaney BJ, Plant & fungal toxins as contaminants of feed & meat, Improving the Safety of Fresh Meat, 2005-Abstract: About 700 non-protein amino acids have been identified in higher plants – these are accumulated in the leaves & seeds but not incorporated into proteins. About 20 of these are known to be toxic in humans or livestock (Hegarty, 1978). Some causing disease in humans include hypoglycin A, which is responsible for vomiting sickness in Jamaica, & several amino acids produced by Lathyrus species & considered to cause two diseases (lathyrism) –one involving skeletal abnormalities, & …
Corrected