Justicia gendarussa (Djapanna-nwè) : medicinal properties in alcoholic extraction

Justicia gendarussa (Djapanna-nwè, Black Ayapana, Stronger-than-the-woman, Ayapana noir, Plus-fort-que-la-femme) — family Acanthacées.

Scientific synonyms : Gendarussa vulgaris-Bojer, G. vulgaris -Nees.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 16 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 69 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of carcinoma: liver, uterine

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Alarmal Mangaï S (2017)

     Excerpt The Chloroform, ethyl acetate & ethanol extract of the plant were used to analyse the cytotoxicity against the human cancer cell lines –human liver carcinoma cancer cell line (HepG2) & cervical cancer cell line (HeLa) by MTT assay. Many research works have been carried out concurrently in last few decades on these plants for cancer treatment & emphasized the importance of clinical support for these plants.

   • According to Elya B (n.d.)

     Excerpt Preminelary experiment showed that ethanolic extract of gendarussa leaves (Justicia gendarussa Burm.) could decreased uric acid blood level on rats. Acute Toxicity of Justicia gendarussa Burm.

   • According to Zain NC (n.d.)

     Excerpt Zain NC et al, EFFECT of 70% ETANOL EXTRACT Justicia gendarussa Burm.f, in CAPSULE to RENAL FUNCTION, LIVER FUNCTION, & LIPID PROFILE to SERUM for NORMAL ADULT MEN, Penulis : Rev Kurniati Septanti.

   • According to Krishna KL (n.d.)

     Excerpt Krishna KL et al, Antioxidant & Hepatoprotective Activity of Leaf Extract of Justicia gendarussa Burm, Int.

   • According to Krishna KL (2010)

     Excerpt Krishna KL et al, IN-VITRO HEPATOPROTECTIVE ACTIVITY OF JUSTICIA GENDARUSSA STEM ON ISOLATED RAT HEPATOCYTES, Pharmacologyonline 2: 9-13, 2010.

2. 2

   Microbial infection: Shigella flexneri, Proteus mirabilis, Escherichia coli, Bacillus subtilis

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sugumaran P (2013)

     Excerpt The obtained biomass of leaves, stem & root were examined for antibacterial activity against various human pathogenic organisms such as Staphylococcus aureus, Escherichia coli, Shigella sp., Pseudomonas sp. Rooting & biomass production of Justicia gendarussa has been achieved through a hydroponic system of cultivation.

   • According to Subramanian N (2012)

     Excerpt gendarussa) showed maximum inhibitory activity against Shigella flexneri (26.20mm), Proteus mirabilis (24.50 mm), Escherichia coli (21.40mm) & Bacillus subtilis (20.25mm) respectively & ethanolic extract showed less inhibitory activity. To evaluate the phytochemical & antimicrobial properties of ethanolic & aqueous extracts of stem & leaves (Justicia gendarussa) against 12 human pathogens.

   • According to Beltrao-Carneiro MR (2023)

     Excerpt The most observed species were Justicia gendarussa Burm., Justicia procumbens L., Justicia adhatoda L., Justicia spicigera Schldl, & Justicia pectoralis Jacq. This study presents a review of the biological activities of plant extracts & isolated chemical constituents of Justicia (ACANTHACEAE), identified in the period from May 2011 to August 2022.

   • According to Sharma K (2011)

     Excerpt & Justicia gendarussa B. Sharma K et al, Antifungal Activity of Solanum Melongena L, Lawsonia Inermis L.

   • According to Hikmawanti NPE (2020)

     Excerpt One of such antiviral herbs is Justicia gendarussa. The effect of the extracts in inhibiting viral replication & fusion process on acute HIV infection was identified through syncytia formation assay.

3. 3

   Arthritis, osteoarthritis, arthritis, rheumatism

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Subramanian N (2013)

     Excerpt Justicia gendarussa has been traditionally used for the treatment of various ailments such as rheumatism, inflammation, nerve diseases, lumbago & chorea. Objective: Thus, J gendarussa was subjected to preliminary anti-anxiety screening studies, with a view to ascertain the verity of its traditional use as an anxiolytic.

   • According to Jothimanivannan C (2010)

     Excerpt The aim of the present study was to evaluate the anti-inflammatory & analgesic activities of the ethanol extract of aerial parts of Justicia gendarussa (EJG) in animal models. The anti-inflammatory activity of the extract was evaluated by using carrageenan-induced rat paw edema & cotton pellet granuloma method.

   • According to Zhang HX (2021)

     Excerpt Three new compounds (1–3), together with six known compounds (4–9), were isolated from the ethyl acetate fraction of ethanol extract of the aerial parts of Justicia gendarussa. Compounds 2 & 3 showed anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC50 values of 20.95 ± 1.11 & 16.50 ± 1.04 μM, respectively.

   • According to Shikha P (2010)

     Excerpt Shikha P et al, Anti-inflammatory & antinociceptive activity of Justicia gendarussa Burm.

   • According to Kumar KS (2012)

     Excerpt gendarussa) is a plant used as traditional medicine in different parts of India and China to treat inflammatory disorders like rheumatoid arthritis. The anti-inflammatory function & mechanism(s) of action was studied in an ethyl acetate fraction isolated from methanolic extract of J.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.