Kalantchoe daigremontiana (Madagascar Kalanchoe) : medicinal properties in alcoholic extraction

Kalantchoe daigremontiana (Madagascar Kalanchoe, Kalanchoé de Madagascar) — family Crassulacées.

Scientific synonyms : Bryophyllum daigremontianum (Raym. -Hamet & H. Perrier) A. Berger.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 12 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of colorectal, liver, breast and uterine carcinoma

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to ALVARADO-PALACIOS QG (2015)

     Excerpt daigremontiana had a better cytotoxic effect (IC50 48.53 μg/ml), compared to the non-encapsulated aqua-ethanolic extract (IC50 61.29 μg/ml) in the MDA-MB-231 metastatic breast cancer cell line. The Aranto (Kalanchoe daigremontiana) is a succulent & xerophytic plant that contains glycosides, flavonoids and lipids; these last ones include triterpenoids & bufadienolides that have cytotoxic activity against various cancer cell lines.

   • According to Supratman U (2001)

     Excerpt daigremontiana x tubiflora (Crassulaceae) were examined for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. These results strongly suggest that bufadienolides are potential cancer chemopreventive agents.

   • According to Stefanowicz-Hajduk J (2020)

     Excerpt In our present study, we analyzed the phytochemical composition of KD ethanol extract & fractions–water & dichloromethane–by the HPLC-DAD-ESI-MS method & estimated cytotoxic activity of the extracts on human adenocarcinoma (HeLa), ovarian (SKOV-3), breast (MCF-7), & melanoma (A375) cell lines by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, real-time cell analyzer (RTCA), & flow cytometry. Studies on the biological activity of this species are scarce, & there is a lack of data on the cytotoxic activity of KD extracts on epithelial cancer cells in the literature.

   • According to Stefanowicz-Hajduk J (2022)

     Excerpt In our study, we analyzed the phytochemical composition of KD water extract using UHPLC-QTOF-MS & estimated the cytotoxic activity of the extract on human ovarian cancer SKOV-3 cells by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, flow cytometry, luminometric, & fluorescent microscopy techniques. The extract showed significant antiproliferative & cytotoxic activity, induced depolarization of the mitochondrial membrane, & significantly arrested cell cycle in the S & G2/M phases of SKOV-3 cells.

   • According to Stefanowicz-Hajduk J (2020)

     Excerpt blossfeldiana ethanol extract did not show the presence of these compounds, Conclusion: K blossfeldiana ethanol extract is a potential candidate for cancer & bacterial infection treatment. Cytotoxicity tests were performed on human cancer cell lines – HeLa, SKOV-3, MCF-7, & A375 by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay & Real-Time Cell Analysis system.

2. 2

   Bacterial infection: Staphylococcus aureus, S. epidermidis, & E. hirae

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Stefanowicz-Hajduk J (2020)

     Excerpt The microbiological study was done using a few bacteria strains (β-hemolytic Streptococcus, Corynebacterium diphtheriae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus hirae, Escherichia coli) & Candida albicans. blossfeldiana ethanol extract did not show the presence of these compounds, Conclusion: K blossfeldiana ethanol extract is a potential candidate for cancer & bacterial infection treatment.

3. 3

   Oxidative stress

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to SHUJAAT S (2017)

     Excerpt The results of various antioxidant assays suggest that the butanol extract exhibits highest antioxidant potential as compared to other solvents (ethanol, dichlorométhane, hexane & water). In present study, different assays have been used to evaluate antioxidant potential of various extracts of K.

   • According to Kolodziejcyk -Czepas J (2016)

     Excerpt Studies on an experimental model of blood plasma under peroxynitrite-induced oxidative stress revealed that the plant preparation had moderate antioxidant properties. Objective: This is the first study on antioxidant effects & cytotoxicity of bufadienolide-rich fraction isolated from Kalanchoe daigremontiana Raym.

   • According to Stefanowicz-Hajduk J (2022)

     Excerpt In keratinocytes treated with menadione, the extract moderately reduced the level of oxidative stress. Additionally, the extract increased the level of oxidative stress in the cancer cell line.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.