Lactuca sativa (Leti) : medicinal properties in alcoholic extraction

Lactuca sativa (Leti, lettuce, Léti, laitue) — family Asteracées.

Scientific synonyms : -L var. : angustana, capitata, crispa, longifolia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 12 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 41 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Riris ID (2022)

     Excerpt Sijukkot (Lactuca indica L), the plants have been from an area in the village of Toba Samosir, North Sumatera, has long been used & believed to be a medicinal plant, especially as a medicine for diabetes, although it has never been studied. We also tested the anti-diabetic activity of the ethanol extract of LS leaves by in vitro using the alpha amylase enzyme inhibition method & the results showed the IC50: 132,413ppm, it has moderate anti-diabetic activity.

2. 2

   Bacterial infection: Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, P. vulgaris, Bacillus subtilis

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to MLADENOVIC JD (2013)

     Excerpt The antimicrobial activity of the lettuce extract, was tested with bacteria from clean cultures Staphylococcus aureus ATCC 25923, Klebsiella pneumoniae ATCC13883, Escherichia coli ATCC 25922, Proteus vulgaris ATCC13315, Proteus mirabilis ATCC14153, Bacillus subtilis ATCC6633, and fungi Candida albicans ATCC10231 & Aspergillus niger ATCC16404. The smallest susceptibility to the ethanolic extract of lettuce was exhibited by the bacteria S aureus & P vulgaris (MIC=78,125 g/ml), while the other selected bacteria and fungi showed higher susceptibility (MIC=39,1 g/ml).

   • According to Ezdiri HL (2011)

     Excerpt Antioxidant, antibacterial & antiviral effects of aqueous & methanol extracts of Lactuca sativa var longifolia leaves were investigated. Methanol & aqueous extracts exhibited antiviral activity against HCMV & Cox-B3 viruses with IC50 of 200 μg/ml.

   • According to Zdravkovic J (2012)

     Excerpt In order to determinate the antimicrobial activity of the extract, clean cultures originating from The Institute of Virology, Vaccines & Sera Torlak: Staphylococcus aureus ATCC 25923, Klebsiella pneumoniae ATCC13883, Escherichia coli ATCC 25922, Proteus vulgaris ATCC13315, Proteus mirabilis ATCC14153, Bacillus subtilis ATCC6633, Candida albicans ATCC10231, Aspergillus niger ATCC16404 have been used. Reference antibiotics used for bacterial strains have been Amracin & Nystatin for fungal strains.

   • According to Al-Nomaani RSS (2013)

     Excerpt Therefore, the essential oils & the crude extracts from Omani vegetable species of lettuce are active candidates which would be used as antioxidant, antifungal or antimicrobial agents in new drugs preparation for therapy of infectious diseases. To isolate and analyse the chemical composition in the essential oils & free radical scavenging activity of different crude extracts from the fresh & dry leaves of vegetable plants of Lactuca sativa.

3. 3

   Cancer: adjuvant treatment for gastrointestinal carcinoma: LS Capitata cv. ‘Melodion’

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sularz O (2021)

     Excerpt The objective of this study was to determine the effect of iodine biofortification (potassium iodate/KIO3/, 5-iodosalicylic acid/5-ISA/, & 3,5-diiodosalicylic acid/3,5-diISA/) on the antioxidant activity of Lactuca sativa L. Moreover, the study has shown that iodine-biofortified LS induces production of ROS in cancer cells, resulting in an anticancer effect by the induction of programmed cancer cell death.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.