Lagerstroemia speciosa (Jèstram) : medicinal properties in alcoholic extraction
Lagerstroemia speciosa (Jèstram) — family Lythracées.
Scientific synonyms : Lagerstroemia Regina-Roxb, L. Ros-Regina-Retz, Munchosia speciosa-L.
This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 20 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 100 scientific references for this species (full detail in the application).
Therapeutic indications in alcoholic extraction:
Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).
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Cancer: adjuvant treatment for liver, breast, leukaemia, lung and uterine cancer, and osteosarcoma
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Singh RT (2020)
Excerpt Hepatocellular carcinoma is the second leading cause of cancer-related mortality worldwide. Lagerstroemia speciosa Pers.
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According to Singh Rohit T (2021)
Excerpt This study investigated the hepatoprotective effect of ethanolic LS leaves extract (EBLE) against dapsone-induced hepatotoxicity in rats. This treatment also increased lipid peroxidation (p < 0.001) & pro-inflammatory markers (tumor necrosis factor-alpha, transforming growth factor-beta, & nuclear factor kappa-B) expressions (p < 0.001) and decreased antioxidants (p < 0.001) such superoxide dismutase, catalase & glutathione in the liver tissue.
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According to Singh R (2020)
Excerpt We investigated the cytotoxic potentials of ethanolic Banaba leaves extract (EBLE) against human hepatocellular carcinoma (HepG2) cell line. Lagerstroemia speciosa (L.) Pers., (Lythraceae) also called Banaba is a native plant of southeast Asia and is widely used in traditional medicinal system.
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According to Singh RT (2021)
Excerpt This study investigates the hepatoprotective effect of ethanolic LS leaves extract (EBLE) against simultaneously administered INH- & DDS-induced hepatotoxicity in rats. This study showed the hepatoprotective efficacy of LS ethanolic extract against simultaneously administered dapsone- & isoniazid-induced hepatotoxicity in rats.
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According to MADKALKAR HM (2022)
Excerpt Antimicrobial, antioxidant, anticancer, antidiabetic, hypolipidemic, antiobesity, anti-inflammatory, analgesic, diuretic, thrombolytic, cardiovascular, central nervous, inhibition of TNFα production, xanthine oxidase production, hepatoprotective, & nephroprotective effects were among the pharmacological effects of LS. Steroids, terpenoids, glycosides, phenolic compounds, -amino acids, saponins, starch, alkaloids, carbohydrates, organic acids, flavonoids, reducing sugars, tannins, & many other active metabolites were found in Lagerstroemia speciosa leaf & fruit,
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Excerpt according to a phytochemical analysis.
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According to Singh RT (2020)
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Hepatotoxicity induced by dapsone and isoniazid
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Singh RT (2021)
Excerpt This study showed the hepatoprotective efficacy of LS ethanolic extract against simultaneously administered dapsone- & isoniazid-induced hepatotoxicity in rats. LS administration was found to decrease dapsone- & isoniazid-induced oxidative stress & hepatic inflammation.
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According to Singh Rohit T (2021)
Excerpt This study investigated the hepatoprotective effect of ethanolic LS leaves extract (EBLE) against dapsone-induced hepatotoxicity in rats. Lagerstroemia speciosa commonly known as Banaba has been traditionally used to treat various ailments including diabetes & obesity due to its antioxidant and anti-inflammatory efficacies.
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According to Kesavanarayanan KS (2013)
Excerpt The dried bulbs of Allium sativum (Garlic) & leaves of Lagerstroemia speciosa (Banaba) are used as medicinal food for the treatment of diabetes & other ailments. METHODS: In the in vitro studies, the effect of standardized aqueous extract of A sativum (ASE), methanolic extract of L speciosa (LSE) & their mixture (1:1 ratio), DIA-2 on insulin stimulated glucose uptake in 3T3-L1 cells, erythrocyte sorbitol accumulation and protein glycation were evaluated.
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According to Singh RT (2020)
Excerpt Lagerstroemia speciosa Pers. Hepatocellular carcinoma is the second leading cause of cancer-related mortality worldwide.
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According to Singh R (2020)
Excerpt Lagerstroemia speciosa (L.) Pers., (Lythraceae) also called Banaba is a native plant of southeast Asia and is widely used in traditional medicinal system. We investigated the cytotoxic potentials of ethanolic Banaba leaves extract (EBLE) against human hepatocellular carcinoma (HepG2) cell line.
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According to Singh RT (2021)
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Diabetic neuropathy
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Nasikkar S (2016)
Excerpt The present study was designed to evaluate effects of Lagerstroemia Speciosa leaves extract in streptozotocin induced diabetic neuropathy. Four weeks after the confirmation of diabetes, diabetic rats were treated with L Speciosa Leaves (LS) extract (200 & 400 mg/kg, p.o) for next four weeks.
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According to Kiran H. B (2016)
Excerpt the present study was design to screen the neuroprotective effects of Lagerstroemia speciosa L.
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According to Bhokare KH (2016)
Excerpt Extract (Banaba Leaf Extract) in Streptozotocin Induced Painful Diabetic Neuropathy in Laboratory Rats. Bhokare KH et al, Neuroprotective Effects of Lagerstroemia speciosa L.
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According to Saha BK (2009)
Excerpt The hypoglycemic effect of Lagerstroemia speciosa leaves hot water extract on chemically induced diabetes in rat was investigated. These studies thus strongly suggest that the hot water extract of leave attributed its prominent hypoglycemic activity on experimental diabetic rats through suppression of gluconeogenesis & stimulation of glucose oxidation using the pentose phosphate pathway,.
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According to Barun KS (2009)
Excerpt Barun KS et al, Hypoglycemic activity of Lagerstroemia speciosa L extract on streptozotocin-induced diabetic rat: Underlying mechanism of action Bangladesh J Pharmacol 2009; 4: 79-83.
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According to Nasikkar S (2016)
Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.
Evolution of this plant record
Under the CTA · public change history
+1 indication · −1 indication · +15 references
Counts and domains only: indication labels and synergy names are not listed here (open the in-app plant file). Bibliographic texts for new, corrected, or removed references expand below.
+15 references — show text
Patil K et al, Antifertility activity of Momordica dioica & Lagerstroemia speciosa in experimental rat, IP Int J Comp Adv Pharmacol. 2022-Abstract: Agents that control fertility is termed as antifertility agents or oral contraceptives. Many plant-based products have the antifertility potential which need to be explored. The present study therefore was undertaken to evaluate possible antifertility effects of hydroalcoholic extract of fruits of MD (HAEMD) & aqueous extract of leaves of LS (AELS) in experimental rats. Experiments were carried using Wistar rats of either sex. Animals were admin…
AddedBREVET: EP-1841440A2: Pharmaceutical, therapeutic, & dietary compositions derived from lagerstroemia speciosa l. plant :An object of the present invention is to provide processes for preparing pharmaceutical, therapeutic, or dietary compositions derived from the Lagerstroemia speciosa L. plant that are rich in natural corosolic acids, ellagitannins, and/or valoneic acids, such that these compositions yield the holistic benefits of the LS leaf, either alone or with other complementary and enhancing constituents. Accordingly, in an aspect of the present invention, economical processes for ma…
AddedPRABHU VV et al, Evaluation of anti-fibrotic effect of Lagerstroemia speciosa (L) Pers on carbon tetrachloride induced liver fibrosis. Current Pharmaceut Res; 1(1):7-12, 2010-Abstract: This study was carried out to investigate the effect of alcoholic extract of Lagerstroemia speciosa (L) pers. against carbon tetrachloride (CCl4) induced liver fibrosis in male albino Wistar rats (150-200gm). Liver fibrosis was induced by twice/week administration of CCl4 at a dose of 1ml/kg body weight, mixed with an equal volume of corn oil. The extent of liver fibrosis was assessed by the content of hydrox…
AddedKesavanarayanan KS et al, DIA-2, a polyherbal formulation ameliorates hyperglycemia & protein-oxidation without increasing the body weight in type II diabetic rats. Euro Review for Med & Pharmacol Sci, 17(3): 356-69, 2013-Abstract: The dried bulbs of Allium sativum (Garlic) & leaves of Lagerstroemia speciosa (Banaba) are used as medicinal food for the treatment of diabetes & other ailments. AIM: The present study was undertaken to ascertain whether the combination of both garlic & banaba extract produces synergistic therapeutic effect in diabetic state. METHODS: In the in vitro studies, t…
AddedSINGH SR et al, A study on the antioxidant, cytotoxicity, & coagulation potential of carbon quantum dots derived from the leaves of Lagerstroemia speciosa, Hybrid Adv, 2025-Abstract: the green synthesis of carbon quantum dots (CQDs) from natural sources offers a sustainable approach in nanotechnology. In this study, CQDs were synthesized from Lagerstroemia speciosa leaves (LS-CQDs) & extensively characterized for their optical, structural, and biological properties. LS-CQDs exhibited UV–Vis absorption peaks at 247 & 351 nm, blue uorescence, a mean particle size of 3.7 nm with a…
AddedBAJPAL M et al, Standardized method to extract phenolic compounds from Lagerstroemia speciosa L. (Jarul) for enhanced antioxidant activity, Jl of Applied & Nat Sci, 13(3):1041-7, 2021-Abstract: Phenolic compounds contribute to the antioxidant property of plants & the efficient extraction of plant phenolics could enhance its antioxidant potential. Lagerstroemia speciosa (L.) Pers. has been investigated for its pharmacological activities, but comparing its antioxidant activities of phenolics derived from its various parts has a key role in developing natural antioxidants. This study was condu…
AddedHAQUE S et al, integrating bioactivity & molecular simulations to explore the pharmacological landscape of Lagerstroemia speciosa leaf extract, Plos-One, 20:12, 2025-Abstract: Natural resources are vital for identifying novel treatments for noncommunicable diseases & multidrug-resistant pathogens. Lagerstroemia speciosa (L. speciosa) Linn. is traditionally used to manage conditions like diabetes, cancer, & oxidative stress-related diseases. Current studies frequently lack comprehensive bioactivity assessments coupled with molecular simulation analyses of LS leaf extracts. We aimed to assess…
AddedSWEETY SP et al, Exploring the anticancer & antioxidant properties of Lagerstroemia speciosa bark extract via phytochemical & molecular docking analysis, Jl Genet Eng. Biotechnol, 23(3):100553. 2025-Abstract: Lagerstroemia speciosa is traditionally used for treating diabetes & inflammation; however, its anticancer potential remains unexplored. This study assesses the antioxidant & anticancer activities of LS bark extract, with a focus on Ehrlich Ascites Carcinoma (EAC) cells in mice. The crude methanol extract (CME) was subdivided into n-hexane (NHF), chloroform (CHF), ethyl acetate (EAF), …
AddedYue Z. et al, Floral Elegance Meets Medicinal Marvels: Traditional Uses, Phytochemistry, & Pharmacology of the Genus Lagerstroemia L, Phytochemistry, & Pharmacology of the Genus Lagerstroemia L. Plants (Basel). 13: 21, 3016, 2024-Abstract: The genus Lagerstroemia L. (Lythraceae), known for its exquisite flowers and prolonged flowering period, is commonly employed in traditional medicinal systems across Asian countries, where it has always been consumed as tea or employed to address ailments such as diabetes, urinary disorders, coughs, fevers, inflammation, pain, & anesthesia. Its diverse us…
AddedBREVET: TW2005-539820A: Process for preparing lagerstroemia speciosa L. Extract-Abstract: The present invention provides a process for preparing a Lagerstroemia speciosa L. extract with low bitterness comprising Lagerstroemia speciosa L. which contains corosolic acid or corosolic acid plus ellagitannin in high proportion as a blood sugar level increase inhibiting component. The process comprises steps of (1) extracting Lagerstroemia speciosa L. with a hydrous organic solvent, concentrating the obtained extract, & dispersing the concentrate in a hydrous organic solvent, (2) subjecting the di…
AddedKhandare K et al, Optimization of supercritical fluid extraction of valuable compounds from Lagerstroemia speciosa leaves for in vitro antidiabetic & antioxidant activity, Sustainable Food Technol, 4(1):865-84, 2025-Abstract: this study reports, for the first time, the optimization of supercritical CO2 extraction (SFE) of phenolic compounds from Lagerstroemia speciosa (LS) leaves using Response Surface Methodology (RSM), targeting both antioxidant & antidiabetic potential. Unlike conventional solvent-based extractions, SFE offers a green & tunable approach to recover thermolabile bioactive …
AddedTjokroprawiro A et al, DLBS3233, a combined bioactive fraction of Cinnamomum burmanii & Lagerstroemia speciosa, in type-2 diabetes mellitus patients inadequately controlled by metformin & other oral antidiabetic agents. Jl Comp & Integr Med 2016;13:41-Abstract: BackgroundDLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa, has preclinically demonstrated its beneficial effects on glucose & lipid metabolism through the upregulation of insulin-signal transduction. This study evaluated the clinical efficacy of an add-on therapy with DLBS3233 in type-2 diab…
AddedGoyal S et al, Bioactive Compound from Lagerstroemia speciosa: Activating Apoptotic Machinery in Pancreatic cancer cells, 3 Biotech. 12 (4):10.1007, 2022- Abstract: The study was aimed at the identification of a potential anti-cancer compound from the leaf extract of Lagerstroemia speciosa, against pancreatic cancer cells (PANC-1). Out of different extracts tested, methanolic extract showed significant cytotoxicity at an IC50 of 289.5 ± 0.03 µg/mL after 24 h (MTT assay). The safety of the extract was ascertained using normal pancreatic cells (hTERT-HPNE). Methanolic extract was able to indu…
AddedDawood A.S et al, Apoptotic mechanism of lantadene A from Lantana camara leaves against prostatic cancer cells. Egypt. Jl. Chem. 64:7503–10, 2021-Abstract:
AddedMADKALKAR HM et al, Lagerstroemia speciosa-Its Ethnobotanical knowledge, Phytochemical studies, Pharmacological aspects, & future prospects. Research-Gate, 2022-Abstract: The purpose of this paper is to highlight the significance of Lagerstroemia speciosa, also known as the Pride of India, Banaba, or Taman plant. Steroids, terpenoids, glycosides, phenolic compounds, -amino acids, saponins, starch, alkaloids, carbohydrates, organic acids, flavonoids, reducing sugars, tannins, & many other active metabolites were found in Lagerstroemia speciosa leaf & fruit, according to a phytochemical analy…
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