Leea indica (Pwa-mannikou) : medicinal properties in alcoholic extraction

Leea indica (Pwa-mannikou, Manicou peas, Pois-à-manicou) — family Vitacées.

Scientific synonyms : Leea gracilis-Lant, L robusta-Blume, L sambucina-Willd, L staphylea-Roxb, L nonvoguineensis-Val, L umbraculifera-CB Clarke, L vididifolia-Plan., Staphylea indica-Burm.f.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 8 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 38 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cirrhosis, hepatitis, fatty liver disease

   Plant part used: Stem bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mishra G (2014)

     Excerpt To evaluate the hepatoprotective activity of ethanolic extract of Leea indica stem bark against paracetamol (PCM) induced hepatotoxicity in rats. Conclusion: The ethanolic extract of LI bark seems to justify the promising hepatoprotective effect on PCM induced liver damage in rats.

   • According to Dalu D (2014)

     Excerpt These results reveal that Leea indica has beneficial effect in reducing blood glucose & lipid levels indicating its efficient antihyperglycemic & hypolipidemic activity. Leaves of Leea indica have multiple pharmacological activities like Antitumour, Analgesic, Antiviral, Sedative & Anxiolytic & NO inhibitory activities.

   • According to Raihan O (n.d.)

     Excerpt In this study the crude methanolic extract of the leaves of Leea indica was examined for their anti tumor, anti-oxidant & cytotoxic activity. These outcomes indicate the possible potential use of LI as anti tumor agent,.

   • According to Raihan O (2012)

     Excerpt In this study the crude methanolic extract of the leaves of Leea indica was examined for their anti-tumor, anti-oxidant & cytotoxic activity. These outcomes indicate the possible potential use of LI as anti-tumor agent.

   • According to Ghagane-Sridevi SC (2017)

     Excerpt To determine the phytochemical constituents, antioxidant & anticancer activities of Leea indica leaf extracts on DU-145 & PC-3 human prostate cancer cell lines. Conclusion : The results indicate that L indica was a promising antioxidant & anticancer agent for DU-145 & PC-3 human prostate cancer cell lines.

2. 2

   Cancer: adjuvant treatment for prostate cancer

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ghagane-Sridevi SC (2017)

     Excerpt To determine the phytochemical constituents, antioxidant & anticancer activities of Leea indica leaf extracts on DU-145 & PC-3 human prostate cancer cell lines. Conclusion : The results indicate that L indica was a promising antioxidant & anticancer agent for DU-145 & PC-3 human prostate cancer cell lines.

   • According to Raihan O (n.d.)

     Excerpt In this study the crude methanolic extract of the leaves of Leea indica was examined for their anti tumor, anti-oxidant & cytotoxic activity. In vivo anti tumor activity was studied against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice by monitoring parameters like tumor weight measurement, survival time & tumor cell growth inhibition.

   • According to Raihan O (2012)

     Excerpt In this study the crude methanolic extract of the leaves of Leea indica was examined for their anti-tumor, anti-oxidant & cytotoxic activity. In vivo anti-tumor activity was studied against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice by monitoring parameters like tumor weight measurement, survival time & tumor cell growth inhibition.

   • According to Reddy NS (2012)

     Excerpt The leaves of Leea indica commonly known as ‘Huo Tong Shu’ in Malaysia, have been traditionally used as natural remedy in folk medicine by the locals. To the best of our knowledge, this is the first report of LI leaf crude ethanol & its fractionated extracts (hexane, ethyl acetate & water) for evaluation of total phenolic content, antioxidant effect & cytotoxic activity against colon cancer cell lines.

   • According to Wong Yau Hsiung (2011)

     Excerpt Wong Yau Hsiung et al, Leea indica Ethyl Acetate Fraction Induces Growth-Inhibitory Effect in Various Cancer Cell Lines & Apoptosis in Ca Ski Human Cervical Epidermoid Carcinoma Cells, Evidence-Based Comp & Alter Med, 2011-doi:10.1155/2011/293060,.

3. 3

   Bacterial infection: E. coli

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Rahman MA (2012)

     Excerpt This study investigated the phytochemical, antioxidative, antimicrobial & cytotoxic effects of Leea indica leaf ethanol extract. In antibacterial screening, the extract showed significant (P < 0.05) zone of inhibitions compared to positive controls Ampicillin & Tetracycline against Gram positive Bacillus subtilis, Bacillus cereus, Bacillus megaterium, & Staphylococcus aureus & Gram negative Salmonella typhi, Salmonella paratyphi, Pseudomonas aeroginosa, Shigella dysenteriae, Vibrio cholerae, & Escherichia coli.

   • According to Tareq SM (2017)

     Excerpt Tareq SM et al, Comparative Anti-dirrhoeal & Antimicrobial Activities of Methanol Extract of Leea indica (Burm.

   • According to Manaf AA (1996)

     Excerpt Cytotoxic activity was present in the extracts from Acalypha indica, Andrographis paniculata, Cerbera manghas, Codiaeum variegatum, Elephantopus scaber, Etlingera elatior, Hibiscus rosa-sinensis, Centella asiatica, M arvensis, Mirabilis Jalapa, Ocimum tenuiflorum, (CD50: 0.001-0.1 mg.mL).Co-existing antiviral & cytotoxic activities were shown by M arvensis. The extracts from Alternanthera sessilis, Eleusine indica, Euphorbia hirta, Leea indica & Solanum americanum were active in selectively inhibiting HSV-1 (0.001-0.1 mg/ml).

   • According to Rokhade VK (2016)

     Excerpt Synthesized silver nanoparticles exhibited synergistic antimicrobial activity in combination with antibiotic against Escherichia coli, Salmonella typhi, Staphylococcus aureus & Bacillus subtilis. In the present investigation fruit extract of Leea indica was used for the synthesis of silver nanoparticles.

   • According to Dalu D (2014)

     Excerpt Leaves of Leea indica have multiple pharmacological activities like Antitumour, Analgesic, Antiviral, Sedative & Anxiolytic & NO inhibitory activities. These results reveal that Leea indica has beneficial effect in reducing blood glucose & lipid levels indicating its efficient antihyperglycemic & hypolipidemic activity.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.