Leonorus sibiricus (Savonnèt) : medicinal properties in alcoholic extraction

Leonorus sibiricus (Savonnèt, Zèb Man Lali, Savonnette, Mrs Lali’s herb, Siberian motherwort, herbe-à-Mme -Lali, Agripaume de Sibérie) — family Lamiacées.

Scientific synonyms : Leonorus manshuricus-YY, L multifidus-(M)-Desf, Panzeria angustifolia-R, P multifida-M, P sibirica-S.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 3 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 38 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for leukaemia

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Krishnan V (2022)

     Excerpt The aim of this study was to evaluate the methanolic extract of aerial parts of Leonurus sibiricus L (LS) for its anticancer activity on HCC cell lines. The carotenoids, lutein & beta carotene present in LS-M extract exhibited anticancer activity.

   • According to Sitarek P (2017)

     Excerpt This is the first study to examine composition of the EOs & their antimicrobial, antioxidant, antiproliferative, & anti‐inflammatory activities. Essential oils obtained from the NR (normal roots) & HR (hairy roots) of the medicinal plant Leonurus sibiricus root were used in this study.

   • According to Sitarek P (2018)

     Excerpt The aim of this study was to determine the anticancer potential of Leonurus sibiricus extract derived from in vitro transgenic roots transformed by Agrobacetrium rhizogenes with AtPAP1 transcriptional factor, & that of transformed roots without construct, on grade IV human glioma cells & the U87MG cell line, & attempt to characterize the mechanism involved in this process. Both the tested extracts showed anticancer properties & the better results were observed for AtPAP1 with transcriptional factor root extract; this effect could be ascribed to the presence of higher condensed phenolic acids such as neochlorogenic acid, chlorogenic acids, ferulic acid, caffeic acid & p-coumaric acid.

   • According to Sitarek P (2017)

     Excerpt We found TR root extract to have antiproliferative activity on glioma cells after 24 h of treatment. This study determines the influence of transformed root (TR) extract of Leonurus sibiricus L.

   • According to Lee MJ (2010)

     Excerpt In Leonurus sibiricus herb extract (LHE)-supplemented animals, plasma cholesterol decreased & high-density lipoprotein-cholesterol increased, resulting in a lowered atherogenic index. In human umbilical vein endothelial cells stimulated with tumor necrosis factor alpha, LHE significantly suppressed intracellular reactive oxygen species, LOX-1, & adhesion molecules.

2. 2

   Gastric ulcer

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Biano LS (2022)

     Excerpt Aim of the study: To evaluate the effect of the ethanol extract of the aerial parts of L.S (EELs) in models of gastric damage in mice. Material & methods: The effect of EELs (50, 100 & 300 mg/kg, p.o., 1 h before induction) was tested on acidified ethanol (ACEt)-induced gastric ulcers.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.