Linum usitatissimum (Grenn’ di Len) : medicinal properties in alcoholic extraction

Linum usitatissimum (Grenn’ di Len, Linseed, Graine de Lin) — family Linacées.

Scientific synonyms : Linum angustifolium subsp. Humile (M) N, L angustifolium subsp. Usitatissimum (L.) R, L Crepitans (B.)-D, L humile Mill, L moroderorum Pau, L usitatissimum subsp. Crepitans Schübl. & G. Martens, L usitatissimum var. humile (Mill.) Pers., L. Utile Salisb..

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 15 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 55 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus (Metformin-like/Glimepride-like: only in synergistic combination)

   Plant part used: Seed. Mentioned synergistic association: Glycyrrhiza glabra-racine.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Qureshi JA (2018)

     Excerpt The purpose of the present experimental study was to assess the antihyperglycemic activity of ethanolic extract of Linum usitatissimum seeds & Glycyrrhiza glabra roots with standard drugs metformin & glimepiride in streptozotocin-induced diabetic rats model. Conclusions: This study indicates that the combination of both L usitatissimum & G glabra extracts have antihyperglycemic & anti hyperlipidemic effects in diabetic rats which might be useful for the search of dietary supplements inefficient management of Type-2 diabetes mellitus.

   • According to Ghule A (2012)

     Excerpt evaluate the effect of ethanolic extract of seeds of Linum usitatissimum (EELU) in hyperglycemia associated reactive oxygen species (ROS) production in peripheral blood mononuclear cells (PBMNCs) & pancreatic antioxidant enzymes in alloxan induced diabetic rat. Conclusions: It is concluded from the investigation that EELU showed antihyperglycaemic effect mediated through inhibition of ROS level in PBMNCs & preservation of endogenous antioxidant enzymes in pancreatic tissue in alloxan induced diabetic rat.

   • According to Pourjafarr A (2019)

     Excerpt Conclusions: It can be concluded that fennel alone & in combination with flaxseed could improve OFR during pregnancy, lactation & afterwards until puberty & menopause.

2. 2

   Cancer: adjuvant treatment for hormone-dependent breast cancer

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Engel N (2015)

     Excerpt The intention of this systematic cell biological study was to analyze the effects of the Phytoestrogen-rich, ethanolic flax root extract (Linum usitatissimum) on human MCF-7 estrogen receptor positive breast cancer cells in order to identify the main antitumor action by focusing on adhesion & migration related features. In conclusion, the flax root extract exhibits antitumor potential for estrogen receptor positive breast cancer cells mainly by remodeling of the actin cytoskeleton, leading to significant reduction of migration & colony formation in vitro.

   • According to Ghule A (2011)

     Excerpt To evaluate an ethanolic extract of seeds of Linum usitatissimum (Linn.) (EELU) for its renoprotective role in rats through its antihypertensive effect & conservation of biological enzymes. EELU also decreased the levels of tumour necrosis factor-α and myeloperoxidase activity.

   • According to Monirul Islam M (2023)

     Excerpt Numerous studies have demonstrated the therapeutic potential of Linum usitatissimum against ovarian cancer, but the specific molecular mechanisms remain elusive. Ovarian cancer is a malignant tumor that primarily forms in the ovaries.

   • According to Abarzua S (2053)

     Excerpt Abarzua S et al, Effects of phytoestrogen extracts from Linum usitatissimum on the Jeg3 human trophoblast tumour cell line.

   • According to Bahmanpour S (2016)

     Excerpt In this study, we compared brain weight and plasma sex hormone levels in young and aged mice after the administration of Linum usitatissimum (flax seed) hydro alcoholic extract. Results: The results of this study shows that the brain weight of mice did not change significantly, but the sex hormone levels in the experimental groups in comparison with the control groups increased significantly (P<0.05).

3. 3

   Bacterial infection: Bacillus subtilis, Enterococcus, Escherichia coli, Salmonella typhi, Staphylococcus aureus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Altwair K (2015)

     Excerpt Phytochemical screening & antimicrobial activity for plants Dracaena cinnabari, Verbena officinal Polygala tenuifolia & Linux usitatissimum.

   • According to Amin T (2014)

     Excerpt The present study was carried out to assess the proximate composition, phytochemical screening: antimicrobial & antioxidant activities of ethanol & chloroform extracts of Linum usitatissimum L. An in vitro antimicrobial assay was carried out by disc diffusion method.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.