Lippia dulcis (Zèb-dous) : medicinal properties in alcoholic extraction

Lippia dulcis (Zèb-dous, Sweet herb, Aztec sugar, Herbe douce, Sucre des Aztèques) — family Verbenacées.

Scientific synonyms : Phylla dulcis-Moldencke, Lippia scaberrima-Mold, Phylla scaberrima (ALJ)-Mold., Zapania scaberrima-Juss. Ex Pers..

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 4 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 17 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Bacterial infection: Escherichia coli, Salmonella enteritidis, Shigella flexneri

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to CACERES A (1993)

     Excerpt Extracts were obtained with three solvents of different polarity (n-hexane, acetone and alcohol) & the in vitro activity was demonstrated against Enteropathogenic Escherichia coli, Salmonella enteritidis & Shigella flexneri. The activity of nine ethanolic extracts against enterobacteria, particularly Acalypha guatemalensis, Diphysa robinioides, Lippia dulcis, Psidium guajava & Spondias purpurea was confirmed.

   • According to COMPADRE CM (1986)

     Excerpt Lippia dulcis Trev., a sweet plant, emerged as a candidate for fractionation studies, & hernandulcin, a sesquiterpene, was isolated & judged by a human taste panel as more than 1000 times sweeter than sucrose. Hernandulcin was nontoxic when administered orally to mice, & it did not induce bacterial mutation,.

2. 2

   Arthritis, osteoarthritis, rheumatism

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Perez S (2005)

     Excerpt ippia dulcis hexane & ethanol extracts were tested for its anti-inflammatory activity in several animal models. Hexane extract showed to be inactive, but the ethanol extract at doses of 400 mg/kg produced significant inhibition of carrageenan-induced paw oedema & reduced the weight of cotton pellet-induced granuloma, moreover, the topical application of 0.5 mg/ear of this extract inhibited the edema induced with TPA by 49.13%, an effect which is of less intensity than that produced by indomethacine at the same dose.

   • According to PEREZ S (2005)

     Excerpt Lippia dulcis hexane & ethanol extracts were tested for its anti-inflammatory activity in several animal models. Hexane extract showed to but the ethanol extract at doses of 400 mg/kg produced significant inhibition of carrageenan-induced paw oedema and reduced the ton pellet-induced granuloma, Moreover, the topical application of 0.5 mg/ear of this extract inhibited the edema induced with TPA an effect which is of less intensity than that produced by indomethacin at the same dose.

   • According to Author (2009)

     Excerpt The cytotoxicity of the ethanolic extract, essential oils, hernandulcin & camphor was examined in human hepatocellular carcinoma cell line (HepG2) & their IC50 values were determined. The essential oil was isolated from the plants by steam distillation and its main components (camphor & hernandulcin) were quantitatively analyzed using HPLC and gas chromatography.

   • According to Gornemann T (2008)

     Excerpt The anti-histaminergic & anti-cholinergic activities of the essential oil of L dulcis support the rational use of the plant or plant extracts to treat bronchospasm. To investigate the essential oil of Lippia dulcis Trev.

3. 3

   Inflammatory pain

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Perez S (2005)

     Excerpt ippia dulcis hexane & ethanol extracts were tested for its anti-inflammatory activity in several animal models. Hexane extract showed to be inactive, but the ethanol extract at doses of 400 mg/kg produced significant inhibition of carrageenan-induced paw oedema & reduced the weight of cotton pellet-induced granuloma, moreover, the topical application of 0.5 mg/ear of this extract inhibited the edema induced with TPA by 49.13%, an effect which is of less intensity than that produced by indomethacine at the same dose.

   • According to PEREZ S (2005)

     Excerpt Lippia dulcis hexane & ethanol extracts were tested for its anti-inflammatory activity in several animal models. Hexane extract showed to but the ethanol extract at doses of 400 mg/kg produced significant inhibition of carrageenan-induced paw oedema and reduced the ton pellet-induced granuloma, Moreover, the topical application of 0.5 mg/ear of this extract inhibited the edema induced with TPA an effect which is of less intensity than that produced by indomethacin at the same dose.

   • According to Author (2009)

     Excerpt The cytotoxicity of the ethanolic extract, essential oils, hernandulcin & camphor was examined in human hepatocellular carcinoma cell line (HepG2) & their IC50 values were determined. The essential oil was isolated from the plants by steam distillation and its main components (camphor & hernandulcin) were quantitatively analyzed using HPLC and gas chromatography.

   • According to Gornemann T (2008)

     Excerpt The anti-histaminergic & anti-cholinergic activities of the essential oil of L dulcis support the rational use of the plant or plant extracts to treat bronchospasm. To investigate the essential oil of Lippia dulcis Trev.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.