Lonicera japonica (Honeysuckle) : medicinal properties in alcoholic extraction

Lonicera japonica (Honeysuckle, Chevrefeuille) — family Caprifoliacées.

Scientific synonyms : Caprifolium japonicum (Thunb.) Kuntze, Lonicera aureoreticulata T.Moore, L brachypoda var. repens Siebold, L brachypoda DC., L chinensis P.W, Lonicera diversifolia Car, L fauriei H.Lév. & Vaniot, L flexuosa var. halliana Dippel, L japonica f. aureoreticulata (T.M) Rehder, L japonica f. chinensis (P.W H.Hara, L japonica f. flexuosa (Thunb.) Zabel, L japonica Thunb., var. japonica, L japonica var. aureoreticulata (T.M) G.Nich, Lonicera japonica var. chinensis (P.W) Baker, L japonica var. repens (Siebold) Rehder, L longiflora auct. non (Lindl.) DC, L miyagusukiana (Ma) Ohwi, L flexuosa Thunb., L japonica var. flexuosa (Thunb.) G.N, L japonica var. halliana (Dip) G.N, L japonica var. miyagusukiana Makino, Nintooa japonica (Thunb.) Sw..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 69 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Flower (flower bud).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shen W (2023)

     Excerpt Here, we found that 3,4-di- O -caffeoylquinic acid isobutyl ester effectively inhibited the proliferation & migration of hepatocellular carcinoma cells, & it displayed less toxicity to a normal liver cell line. We have purified a novel caffeoylquinic acid named 3,4-di- O -caffeoylquinic acid isobutyl ester from the flower buds of Lonicera japonica Thunb., Caprifoliaceae.

   • According to Li W (2024)

     Excerpt Pharmacological studies have shown that LJF & LF have various anti-inflammatory, antiviral, antibacterial, anti-endotoxic, antioxidant, anti-tumor, anti-platelet, myocardial protective, & hepatoprotective effects. Lonicerae japonicae flos (LJF) & Lonicerae flos (LF) belong to different genera of Caprifoliaceae with analogous appearances & functions.

   • According to Ge L (2018)

     Excerpt Lonicera japonica Thunb., possesses antiviral & hepatoprotective activities, & is widely used as a health food & in cosmetic.

   • According to Miao H. (2019)

     Excerpt Lonicerae Japonicae Flos (dried flower buds of Lonicera japonica Thunb) is a traditional heat-clearing & detoxifying herbal medicine in China.

   • According to Teng Y (2010)

     Excerpt The aim of this study is to investigate effects of Flos lonicera extract (FLE) on acute liver injury model rats which induced by 35 mg/kg diethylnitrosamine (DMN). Model rats were divided into hepatic injury control group (administrated with water), FLE group (administrated with FLE) and silymarin group (administrated with silymarin which is hepato therapeutic drug) as positive control.

2. 2

   Diabetic nephropathy

   Plant part used: Flower (flower bud).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Tzeng TF (2014)

     Excerpt The anti-inflammatory potential of Lonicera japonica makes it an excellent source of novel medicinal targets to reduce inflammation in diabetic nephropathy. We aimed to investigate whether the ethanol extract of the flowering aerial parts of LJ exerts an ameliorative effect on diabetic renal inflammation using streptozotocin-induced diabetic rats.

   • According to Yang, L (2023)

     Excerpt The regulatory effects of Lonicera japonica flos on fecal microbiota from humans with type 2 diabetes in a SHIME model.

   • According to Yang X (2023)

     Excerpt Lonicera japonica Thunb. The anti-diabetic, anti-Alzheimer's disease, anti-depression, antioxidative, immunoregulatory, anti-tumor, anti-inflammatory, anti-allergic, anti-gout, & anti-alcohol-addiction effects of LJ can also be explained by bioactive polysaccharides isolated from this plant.

   • According to GAO S (2024)

     Excerpt Lonicera japonica Thunb., commonly referred to as Caprifolium japonicum (Thunb.) Dum. Lonicera japonica Thunb.

   • According to Wang D (2017)

     Excerpt In this study, one fraction of the crude polysaccharides extracted from Lonicera japonica flower buds (LJP) were investigated for its hypolipidaemic & hypoglycaemic activities by means of streptozotocin (STZ)-induced diabetic rats. The results suggested that LJP could be considered as an ingredient of functional foods for diabetes, & this is the first report about the hypoglycemic & hypolipidemic effects of the polysaccharides extracted from Lonicera japonica.

3. 3

   Viremia: hepatitis (HBV)

   Plant part used: Flower (flower bud).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Zhao YY (2015)

     Excerpt Lonicera Japonica Flos is mainly used for the treatment of respiratory tract virus infection while Lonicera Japonica Caulis is mainly used for the treatment of hepatitis virus infection, respectively. Lonicera Japonica Flos, Lonicera Japonica Caulis and Lonicera Japonica Folium are the typical representative of this phenomenon.

   • According to Yang X (2023)

     Excerpt japonica is a phyto antibiotic with broad-spectrum antibacterial activity & a potent therapeutic effect on various infectious diseases. Lonicera japonica Thunb.

   • According to Shang X (2011)

     Excerpt LJ & its active principles possess wide pharmacological actions, such as anti-inflammatory, antibacterial, antiviral, antioxidative & hepatoprotective activities. Lonicera japonica Thunb.

   • According to Li W (2024)

     Excerpt Pharmacological studies have shown that LJF & LF have various anti-inflammatory, antiviral, antibacterial, anti-endotoxic, antioxidant, anti-tumor, anti-platelet, myocardial protective, & hepatoprotective effects. Lonicerae japonicae flos (LJF) & Lonicerae flos (LF) belong to different genera of Caprifoliaceae with analogous appearances & functions.

   • According to Shi Z (2016)

     Excerpt Shi Z et al, Spectrum-Effect Relationships Between Chemical Fingerprints & Antibacterial Effects of Lonicerae Japonicae Flos & Lonicerae Flos Base on UPLC & Microcalorimetry.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.