Nelumbo nucifera (Sacred Lotus) : medicinal properties in alcoholic extraction
Nelumbo nucifera (Sacred Lotus, Lotus sacré) — family Nymphéacées.
Scientific synonyms : Nelumbo lutea-Pers, N speciosa Willd. N pentapetala-(W)-Willd.
This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 26 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 147 scientific references for this species (full detail in the application).
Therapeutic indications in alcoholic extraction:
Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).
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Type II diabetes mellitus
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Sakuljaitrong S (2013)
Excerpt This study was aimed to investigate an acute toxicity & effects of Nelumbo nucifera flower extract (NNFE) on hyperglycemic &hypolipidemic effects in streptozytocin-induced diabetic rats. Furthermore, the extract at a dose of 250 mg/kg significantly (p<0.05) decreased the levels of fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), & blood urea nitrogen (BUN) but increased high density lipoprotein (HDL) in the NNFE- treated diabetic rats compared to diabetic controls.
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According to RAKESH P (2011)
Excerpt The present study is aimed to evaluate the anti diabetic effect of Nelumbo nucifera rhizome & flower extracts on serum glucose level in normal & streptozotocin induced diabetic rats. The various extracts was prepared & screened for their effects on serum glucose level in rahese studies, we can conclude that the NN rhizome & flower extract is a promising anti diabetic agent.ts.
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According to Huralikuppi† JC (1991)
Excerpt Nelumbo nucifera Gaertn, an Indian aquatic herb, has been studied for its potential utility in the treatment of Diabetes mellitus. The powdered sun-dried flowers (test drug), as well as the aqueous & alcoholic extracts of these, produced significant hypoglycaemia in fasting normal albino rabbits.
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According to Bangar SP (2022)
Excerpt Hence, the review deals with the nutritional composition of the LS & bioactivities of LS extracts, viz., anti-cancer, anti-proliferation, anti-diabetic, anti-inflammatory, neuroprotective, antioxidant, & immunomodulatory action. Lotus is a member of a small family of Nelumbonaceae & is regarded as a sacred flower grown as a freshwater aquatic plant.
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According to Sakuljaitrong S (2012)
Excerpt Sakuljaitrong S et al, Effect of Flower Extract from Lotus (Nelumbo nucifera) on Haematological Values & Blood Cell Characteristics in Streptozotocin-induced Diabetic Rats, ARPN J of Sci &Technol, 2,11, 2012,.
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According to Sakuljaitrong S (2013)
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Cirrhosis, hepatitis, fatty liver disease
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Wang Z (2021)
Excerpt Lotus (Nelumbo nucifera Gaertn.) is a water plant belonging to the family Nelumbonacea that is cultivated in many areas of the world, and it is mainly composed of petals, seeds, leaves, and roots. Scope & approach :The aim of this review was to evaluate the scientific evidence for the health benefits of the Nelumbo nucifera leaves (NLEs) based on their pharmacokinetic properties.
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According to You Y (2018)
Excerpt The protective activity of a mixture of aqueous & ethanolic extracts from Houttuynia cordata Thunb, Nelumbo nucifera G. These results suggest that HNC might be a candidate agent for liver protection against ethanol-induced oxidative damage, through enhancement of antioxidant & antilipogenic activity.
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According to Sohn DH (2003)
Excerpt Ethanol extracts from Nelumbo nucifera (ENN) seeds were studied for possible antioxidative & hepatoprotective effects. Hepatoprotective effects were tested using carbon tetrachloride (CCl4) & aflatoxin B1 (AFB1)-induced hepatocyte toxicity models.
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According to Zhao X (2023)
Excerpt Nelumbo nucifera Gaertn, commonly known as lotus, is a genus comprising perennial & rhizomatous aquatic plants, found throughout Asia and Australia. In the traditional medicine systems & previous scientific studies, bioactive compounds& the extracts of lotus have been applied for treating inflammation, cancer, liver disease, Alzheimer’s disease, etc.
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According to Wang Y (2019)
Excerpt Leaf extract of Nelumbo nucifera (NLE) has been demonstrated to possess anti-atherosclerosis, improve alcohol-induced steatohepatitis, prevent high-fat diet-induced obesity, & inhibit the proliferation & metastasis of human breast cancer cells. After the 6-month experiment, NLE supplementation resulted in decreasing AAF-induced serum parameters of hepatic injury, including the level of triglycerides, total cholesterol, alpha-fetoprotein (AFP), & inflammatory mediator interleukin (IL)-6 & tumor necrosis factor (TNF)-α as well as the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), & gamma-glutamyl transferase (γGT).
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According to Wang Z (2021)
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Hepatitis, cirrhosis, fatty liver
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Sohn DH (2003)
Excerpt Ethanol extracts from Nelumbo nucifera (ENN) seeds were studied for possible antioxidative & hepatoprotective effects. Hepatoprotective effects were tested using carbon tetrachloride (CCl4) & aflatoxin B1 (AFB1)-induced hepatocyte toxicity models.
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According to You Y (2018)
Excerpt The protective activity of a mixture of aqueous & ethanolic extracts from Houttuynia cordata Thunb, Nelumbo nucifera G. These results suggest that HNC might be a candidate agent for liver protection against ethanol-induced oxidative damage, through enhancement of antioxidant & antilipogenic activity.
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According to Zhao X (2023)
Excerpt Nelumbo nucifera Gaertn, commonly known as lotus, is a genus comprising perennial & rhizomatous aquatic plants, found throughout Asia and Australia. In the traditional medicine systems & previous scientific studies, bioactive compounds& the extracts of lotus have been applied for treating inflammation, cancer, liver disease, Alzheimer’s disease, etc.
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According to Wang Y (2019)
Excerpt Leaf extract of Nelumbo nucifera (NLE) has been demonstrated to possess anti-atherosclerosis, improve alcohol-induced steatohepatitis, prevent high-fat diet-induced obesity, & inhibit the proliferation & metastasis of human breast cancer cells. After the 6-month experiment, NLE supplementation resulted in decreasing AAF-induced serum parameters of hepatic injury, including the level of triglycerides, total cholesterol, alpha-fetoprotein (AFP), & inflammatory mediator interleukin (IL)-6 & tumor necrosis factor (TNF)-α as well as the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), & gamma-glutamyl transferase (γGT).
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According to Wang Z (2021)
Excerpt Lotus (Nelumbo nucifera Gaertn.) is a water plant belonging to the family Nelumbonacea that is cultivated in many areas of the world, and it is mainly composed of petals, seeds, leaves, and roots. Scope & approach :The aim of this review was to evaluate the scientific evidence for the health benefits of the Nelumbo nucifera leaves (NLEs) based on their pharmacokinetic properties.
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According to Sohn DH (2003)
Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.
Evolution of this plant record
Under the CTA · public change history
+11 references · −11 references
Counts and domains only: indication labels and synergy names are not listed here (open the in-app plant file). Full bibliographic texts for new, corrected, or removed references expand below.
+11 references — show text
Mukherjee PK et al, Diuretic activity of extract of the rhizomes of Nelumbo nucifera Gaertn. (Fam. Nymphaeaceae), Phytother Res, 10 (5) :424-5, 1996-Abstract: The diuretic efficacy of the rhizomes of Nelumbo nucifera was studied on albino rats. The methanol extract of the rhizomes induced significant diuresis in rats. Dose dependent effects were observed in urine volume & electrolyte excretion. There was a significant increase in natriuretic & chloruretic activity but kaliuresis was less than natriuresis,
AddedTungmunnithum D et al, Phytochemical Diversity & Antioxidant Potential of Natural Populations of Nelumbo nucifera Gaertn. throughout the Floristic Regions in Thailand, Molecules, 27(3):681, 2022-Abstract: This present study provided the frontier results to fill-in this necessary gap to investigating the phytopharmaceutical potential of perianth & stamen, which represent an important part for Asian traditional medicines, from 18 natural populations throughout Thailand by (1) determining their phytochemical profiles, such as total contents of phenolic, flavonoid, & anthocyanin, & (2) determin…
AddedYou JS et al, Ethanol extract of lotus (Nelumbo nucifera) root exhibits an anti-adipogenic effect in human pre-adipocytes & anti-obesity & anti-oxidant effects in rats fed a high-fat diet, Nutr Res, 34(3) :258-67, 2014-Abstract : Lotus (Nelumbo Nucifera) root, a well-known medicinal plant in Asia, is reported to have various therapeutic benefits, including anti-diabetes, anti-hypertension, & anti-hyperlipidaemia. We hypothesized that the ethanol extract of lotus root (ELR) would exhibit an anti-adipogenic effect in human pre-adipocytes as well as anti-obesity & anti-oxidant effects in rats …
AddedUthirapathy S et al, Nelumbo Nucifera in Male Wistar Rats, Inter J of Pharm Practice, 5(1):935-40, 2014-Abstract: In the present research, the Hyperlipidemia activity of Nelumbo nucifera Flower (NN) along with their phytochemical evaluation has been done. The Hyperlipidemia effect of hydroalcoholic extract of NN Flower was evaluated in Poloxamer 407 induced hyperlipidemic in male Wistar rats. Hyperlipidemia was induced by giving Poloxamer 407 intrapertonial route for 15 days. The groups of rats selected for the study were treated with Atorvastatin, ethanol extract of NN. The analysis of lip…
AddedBrindha D et al, Antiplatelet activity of white & pink Nelumbo nucifera Gaertn flowers, Braz J of Pharmaceut Sci, 46’3) :579-83, 2010-Abstract: Nelumbo nucifera, a plant used in Ayurvedic medicine is a perennial, large & rhizomatous aquatic herb most prevalent in South India. Preliminary phytochemical screening of both white & pink NN flowers revealed the presence of phytochemical constituents (flavonoids, alkaloids, phenols etc,). Hence, an attempt has been made to screen the effect of NN flowers (both types) on platelet aggregation. The antiplatelet activity of hydroethanolic extract of b…
AddedTungmunnithum D et al, Validation of a High-Performance Liquid Chromatography with Photodiode Array Detection Method for the Separation & Quantification of Antioxidant & Skin Anti-Aging Flavonoids from Nelumbo nucifera Gaertn. Stamen Extract, Molecules, 27(3):1102, 2022-Abstract: Nelumbo nucifera Gaertn., or the so-called sacred lotus, is a useful aquatic plant in the Nelumbonaceae family that has long been used to prepare teas, traditional medicines as well as foods. Many studies reported on the phytochemicals & biological activities of its leaves and seeds. However, to date, only few stud…
AddedMukherjee PK et al, Studies on antipyretic activity of Nelumbo nucifera rhizome extract, Indian J Exp Biol, 1996, 82, 274-6.
AddedBrindha D et al, Antimicrobial Activity of White & Pink Nelumbo Nucifera Gaertn Flowers, Asian J of Pharmaceut Res & Health Care, 2010; 2(2)-Abstract: Nelumbo nucifera Gaertn (Family: Nelumbonaceae), medicinally versatile & used as an important raw material of age-old traditional medical practices like Ayurveda & folk medicine. Bioassays for antimicrobial activities were carried out using hydroethanolic extract of both white & pink flowers of Nelumbo nucifera plant. Both the flower extracts were tested against five important bacterial strains & two fungal strains. Further, Minimum Inhibitor…
AddedMukherjee PK et al, Studies on psychopharmacological effect of Nelumbo nucifera Gaertn. rhizome extract, J Ethnopharmacol, 1996, 54, 63-67-Abstract : Methanolic extract of rhizomes of Nelumbo nucifera was investigated for different psychopharmacological actions in rats & mice. The extract was found to cause reduction in spontaneous activity, decrease in exploratory behavioural pattern by the head dip & Y-maze test, reduction in muscle relaxant activity by rotarod, 30° inclined screen & traction test & potentiated the pentobarbitone induced sleeping time in mice significantly.
AddedUthirapathy S et al, Phytochemical Analysis & Anti Hyperlipidemic Activity of Nelumbo Nucifera in Male Wistar Rats, Research-gate, 2014-Abstract: Hyperlipidemia is the leading cause for the development of various diseases made pharmaceutical companies to turn towards the herbal products with fewer side effects. In the present research, the Hyperlipidemia activity of Nelumbo nucifera Flower (NN) along with their phytochemical evaluation has been done. The Hyperlipidemia effect of hydroalcoholic extract of NN Flower was evaluated in Poloxamer 407 induced hyperlipidemic in male Wistar rats. Hy…
AddedYou JS et al, Anti- obesity & hypolipidaemic effects of Nelumbo nucifera seed ethanol extract in human pre-adipocytes & rats fed a high-fat diet. J Sci Food Agric. 2014; 94(3): 568–55-Abstract : We conducted this investigation in order to examine the anti-obesity & hypolipidaemic effects of Nelumbo nucifera seed ethanol extract (NSEE) in vitro & in vivo. METHODS : To study the anti-obesity effect of NSEE in vitro & in vivo, human pre-adipocytes were treated with NSEE, & male Sprague–Dawley rats were fed with a normal diet and a high-fat diet with or without NSEE, respectively. RESULTS : In …
AddedMukherjee PK et al, Diuretic activity of extract of the rhizomes of Nelumbo nucifera Gaertn. (Fam. Nymphaeaceae), Phytother Res, 10 (5) :424-5, 1996-Abstract: The diuretic efficacy of the rhizomes of Nelumbo nucifera was studied on albino rats. The methanol extract of the rhizomes induced significant diuresis in rats. Dose dependent effects were observed in urine volume & electrolyte excretion. There was a significant increase in natriuretic & chloruretic activity but kaliuresis was less than natriuresis,
RemovedTungmunnithum D et al, Phytochemical Diversity & Antioxidant Potential of Natural Populations of Nelumbo nucifera Gaertn. throughout the Floristic Regions in Thailand, Molecules, 27(3):681, 2022-Abstract: This present study provided the frontier results to fill-in this necessary gap to investigating the phytopharmaceutical potential of perianth & stamen, which represent an important part for Asian traditional medicines, from 18 natural populations throughout Thailand by (1) determining their phytochemical profiles, such as total contents of phenolic, flavonoid, & anthocyanin, & (2) determin…
RemovedYou JS et al, Ethanol extract of lotus (Nelumbo nucifera) root exhibits an anti-adipogenic effect in human pre-adipocytes & anti-obesity & anti-oxidant effects in rats fed a high-fat diet, Nutr Res, 34(3) :258-67, 2014-Abstract : Lotus (Nelumbo Nucifera) root, a well-known medicinal plant in Asia, is reported to have various therapeutic benefits, including anti-diabetes, anti-hypertension, & anti-hyperlipidaemia. We hypothesized that the ethanol extract of lotus root (ELR) would exhibit an anti-adipogenic effect in human pre-adipocytes as well as anti-obesity & anti-oxidant effects in rats …
RemovedUthirapathy S et al, Nelumbo Nucifera in Male Wistar Rats, Inter J of Pharm Practice, 5(1):935-40, 2014-Abstract: In the present research, the Hyperlipidemia activity of Nelumbo nucifera Flower (NN) along with their phytochemical evaluation has been done. The Hyperlipidemia effect of hydroalcoholic extract of NN Flower was evaluated in Poloxamer 407 induced hyperlipidemic in male Wistar rats. Hyperlipidemia was induced by giving Poloxamer 407 intrapertonial route for 15 days. The groups of rats selected for the study were treated with Atorvastatin, ethanol extract of NN. The analysis of lip…
RemovedBrindha D et al, Antiplatelet activity of white & pink Nelumbo nucifera Gaertn flowers, Braz J of Pharmaceut Sci, 46’3) :579-83, 2010-Abstract: Nelumbo nucifera, a plant used in Ayurvedic medicine is a perennial, large & rhizomatous aquatic herb most prevalent in South India. Preliminary phytochemical screening of both white & pink NN flowers revealed the presence of phytochemical constituents (flavonoids, alkaloids, phenols etc,). Hence, an attempt has been made to screen the effect of NN flowers (both types) on platelet aggregation. The antiplatelet activity of hydroethanolic extract of b…
RemovedTungmunnithum D et al, Validation of a High-Performance Liquid Chromatography with Photodiode Array Detection Method for the Separation & Quantification of Antioxidant & Skin Anti-Aging Flavonoids from Nelumbo nucifera Gaertn. Stamen Extract, Molecules, 27(3):1102, 2022-Abstract: Nelumbo nucifera Gaertn., or the so-called sacred lotus, is a useful aquatic plant in the Nelumbonaceae family that has long been used to prepare teas, traditional medicines as well as foods. Many studies reported on the phytochemicals & biological activities of its leaves and seeds. However, to date, only few stud…
RemovedMukherjee PK et al, Studies on antipyretic activity of Nelumbo nucifera rhizome extract, Indian J Exp Biol, 1996, 82, 274-6.
RemovedBrindha D et al, Antimicrobial Activity of White & Pink Nelumbo Nucifera Gaertn Flowers, Asian J of Pharmaceut Res & Health Care, 2010; 2(2)-Abstract: Nelumbo nucifera Gaertn (Family: Nelumbonaceae), medicinally versatile & used as an important raw material of age-old traditional medical practices like Ayurveda & folk medicine. Bioassays for antimicrobial activities were carried out using hydroethanolic extract of both white & pink flowers of Nelumbo nucifera plant. Both the flower extracts were tested against five important bacterial strains & two fungal strains. Further, Minimum Inhibitor…
RemovedMukherjee PK et al, Studies on psychopharmacological effect of Nelumbo nucifera Gaertn. rhizome extract, J Ethnopharmacol, 1996, 54, 63-67-Abstract : Methanolic extract of rhizomes of Nelumbo nucifera was investigated for different psychopharmacological actions in rats & mice. The extract was found to cause reduction in spontaneous activity, decrease in exploratory behavioural pattern by the head dip & Y-maze test, reduction in muscle relaxant activity by rotarod, 30° inclined screen & traction test & potentiated the pentobarbitone induced sleeping time in mice significantly.
RemovedUthirapathy S et al, Phytochemical Analysis & Anti Hyperlipidemic Activity of Nelumbo Nucifera in Male Wistar Rats, Research-gate, 2014-Abstract: Hyperlipidemia is the leading cause for the development of various diseases made pharmaceutical companies to turn towards the herbal products with fewer side effects. In the present research, the Hyperlipidemia activity of Nelumbo nucifera Flower (NN) along with their phytochemical evaluation has been done. The Hyperlipidemia effect of hydroalcoholic extract of NN Flower was evaluated in Poloxamer 407 induced hyperlipidemic in male Wistar rats. Hy…
RemovedYou JS et al, Anti- obesity & hypolipidaemic effects of Nelumbo nucifera seed ethanol extract in human pre-adipocytes & rats fed a high-fat diet. J Sci Food Agric. 2014; 94(3): 568–55-Abstract : We conducted this investigation in order to examine the anti-obesity & hypolipidaemic effects of Nelumbo nucifera seed ethanol extract (NSEE) in vitro & in vivo. METHODS : To study the anti-obesity effect of NSEE in vitro & in vivo, human pre-adipocytes were treated with NSEE, & male Sprague–Dawley rats were fed with a normal diet and a high-fat diet with or without NSEE, respectively. RESULTS : In …
Removed