Neolamarckia cadamba (Kadamba) : medicinal properties in alcoholic extraction

Neolamarckia cadamba (Kadamba) — family Rubiacées.

Scientific synonyms : Anthocephalus cadamba (Roxb.) Miq., A indicus var. glabrescens H.L.Li, A indicus var. macrophyllus Pierre, A morindifolius Korth., A indicus var. macrophyllus Pierre ex Pit., Nauclea cadamba Roxb. N megaphylla S.Moore, Neonauclea megaphylla (S.Moore) S.Moore, Samama cadamba (Roxb.) Kuntze, Sarcocephalus cadamba (Roxb.) Kurz.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 27 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: bark & stem.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to YADAV JP (2024)

     Excerpt Traditional Chinese Medicine (TCM), Neolamarckia cadamba (NMCA), a member of the Rubiaceae family, is well-known for its rich assortment of phytochemicals & has a historical use in addressing various health issues. This study aimed to assess HPTLC analysis & explore the wound healing, antidiabetic, & antioxidant properties of optimized extracts from NMCA stems & bark.

   • According to Munira S (2020)

     Excerpt Various parts i.e., stem bark, leaf, root & flower of Neolamarckia cadamba (Roxb.) Bosser has been extensively used by traditional practitioners to treat all types of diabetes. Our present study investigated the antidiabetic property of the extract from its flower & evaluated its traditional use for diabetes.

   • According to Ahmed F (2011)

     Excerpt Neolamarckia cadamba (Rubiaceae) leaf is used in folk medicine of Bangladesh for the treatment of diabetes, but so far, no scientific study has been done which may support its use in traditional medicine. Maximum anti-hyperglycemic activity was shown at 400 mg per kg body weight, which was comparable to that of, Glibenclamide (10 mg/kg).

   • According to PANDEY A (2016)

     Excerpt One such under-explored plant is an evergreen tropical tree Neolamarckia cadamba (Roxb.) Bosser (Rubiaceae). It is widely distributed in tropical & subtropical regions of the world & has therapeutic potential against many diseases such as diabetes, anaemia, stomatitis, leprosy, cancer & infectious diseases.

   • According to REN R (2023)

     Excerpt We previously reported the monoterpenoid indole alkaloids (MIAs) cadambine biosynthetic pathway in Neolamarckia cadamba, a woody tree species that provides an important traditional medicine widely used to treat diseases such as diabetes, leprosy, & cancer in Southeast Asia.

2. 2

   Cancer: adjuvant treatment for breast cancer

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Razali S (2021)

     Excerpt The leaves of Neolamarckia cadamba (NC) (Roxb.) Bosser (family: Rubiaceae) are traditionally used to treat breast cancer in Malaysia; however, this traditional claim is yet to be scientifically verified. Hence, this study was aimed to evaluate the anticancer effect of NC leaves’ ethanol extract against breast cancer cell line (MCF-7 cells) using an in vitro cell viability, cytotoxicity, & gene expression assays followed by the gas chromatography analysis to further confirm active principles.

   • According to ZHAO X (2022)

     Excerpt Three majors glycosidic monoterpenoid indole alkaloids (MIAs), cadambine and its derivatives 3β-is dihydrocadambine & 3β-dihydrocadambine, accumulate in the bark & leaves, & exhibit antimalarial, antiproliferative, antioxidant, anticancer & anti-inflammatory activities. cadamba (Roxb.), a close relative of Coffea canephora and Ophiorrhiza pumila, is an important traditional medicine in Southeast Asia.

   • According to PANDEY A (2016)

     Excerpt One such under-explored plant is an evergreen tropical tree Neolamarckia cadamba (Roxb.) Bosser (Rubiaceae). It is widely distributed in tropical & subtropical regions of the world & has therapeutic potential against many diseases such as diabetes, anaemia, stomatitis, leprosy, cancer & infectious diseases.

   • According to REN R (2023)

     Excerpt We previously reported the monoterpenoid indole alkaloids (MIAs) cadambine biosynthetic pathway in Neolamarckia cadamba, a woody tree species that provides an important traditional medicine widely used to treat diseases such as diabetes, leprosy, & cancer in Southeast Asia.

3. 3

   Oxidative stress

   Plant part used: bark & stem.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to YADAV JP (2024)

     Excerpt Traditional Chinese Medicine (TCM), Neolamarckia cadamba (NMCA), a member of the Rubiaceae family, is well-known for its rich assortment of phytochemicals & has a historical use in addressing various health issues. This study aimed to assess HPTLC analysis & explore the wound healing, antidiabetic, & antioxidant properties of optimized extracts from NMCA stems & bark.

   • According to ZHAO X (2022)

     Excerpt Three majors glycosidic monoterpenoid indole alkaloids (MIAs), cadambine and its derivatives 3β-is dihydrocadambine & 3β-dihydrocadambine, accumulate in the bark & leaves, & exhibit antimalarial, antiproliferative, antioxidant, anticancer & anti-inflammatory activities. cadamba (Roxb.), a close relative of Coffea canephora and Ophiorrhiza pumila, is an important traditional medicine in Southeast Asia.

   • According to Kumar D (2020)

     Excerpt The present study was to evaluate the qualitative estimation of phytochemicals & antioxidant properties from leaves, stem, & root of Neolamarckia cadamba & Cymbopogon citratus. In the present study, free radical scavenging percentage activity was found maximum in aqueous stem extract of Neolamarckia cadamba (81% with 1.5 ml extract) & least in aqueous stem & leaf extract of Cymbopogon citrates (1.67% & 1.67% with 0.5 ml respectively).

   • According to Ganjewala D (2013)

     Excerpt Ganjewala D et al, Phytochemical composition & antioxidant properties of methanol extracts of leaves & fruits of Neolamarckia cadamba (Roxb).

   • According to Shrivastava AK (2023)

     Excerpt Among the studied plants, Neolamarckia cadamba exhibited the highest total phenolic & tannin contents, as 241.53 ± 0.20 µg of gallic acid equivalent/mg & 74.48 ± 1.081 µg of tannic acid equivalent/mg, respectively. Moreover, Raphanus sativus demonstrated significant ferrous ion chelating, 2,2-diphenyl-1-picrylhydrazyl, hydrogen peroxide scavenging, & total antioxidant activities with IC50 value of 4.76 ± 0.68 µg/mL, 5.84 ± 0.14 µg/mL, 6.89 ± 0.16 µg/mL, & 8.99 ± 0.20 µg/mL, respectively.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.