Nepheleum lappaceum (Rambutan) : medicinal properties in alcoholic extraction

Nepheleum lappaceum (Rambutan, Ranboutan, Ramboutan) — family Sapindacées.

Scientific synonyms : Dimocarpus crinitus Lour., Euphoria crinita Poir., Euphoria nephelium Poir., Euphobria nephelium DC, Nephelium lappaceum Linn., N ramb-outan Labi.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 109 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Fruit peel.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Suhendi A (2015)

     Excerpt Group I (negative control) were given a solution of 0.5% CMC-Na, group II (positive control antidiabetic) was given Glibenclamide 0.45 mg/kg, III, IV, & V were given ethanol extract of NL peel with successive doses of 500, 250, & 125 mg/kgBW. The results showed that the ethanol extract of NL fruit peel with dose of 125, 250, & 500 mg/kgBW had blood glucose lowering activity in mice induced alloxan, the percentage decrease in blood glucose levels at 22.65 ± 2.10%, 49.05 ± 3.22%, 61.76 ± 4.26%.

   • According to Muhtadi M (2016)

     Excerpt This research study aimed to explore the antidiabetic & antihypercholesterolemia activities of rambutan (Nephelium lappaceum L.) & durian (Durio zibethinus Murr.) fruit peels extracts. Diabetic rats induced by alloxan intra-peritoneal at dose 150 mg/kg.bw.

   • According to Sukmandari NS (2017)

     Excerpt A thorough literature survey revealed that the plant possesses several biological activities such as antidiabetic, analgesic, antiinflammatory, immunomodulatory, antioxidant, anticancer, antimicrobial & antiviral activities against dengue virus. The plant has been used as traditional medicine for centuries especially as a remedy for diabetes & high blood pressure.

   • According to Adawiyah Rabiatul (2019)

     Excerpt Adawiyah Rabiatul et al, Dermiati, Antidiabetic Activity Test of Rambutan Fruit Skin Fraction (Nephalium lappaceum L.) in Male White Rats (Rattus norvegicus) Hypercholesterolemia-Diabetes, Pharmacol J of Pharm, XVI (1) 2019: 69–79-Abstract:.

   • According to Author (2019)

     Excerpt Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia due to abnormalities of the metabolism of carbohydrates, fats, & proteins. This research is experimental research aims to produce syrup for the treatment of diabetes with various concentrations of propylene glycol as a cosolvent.

2. 2

   Cardiovascular risk in people with diabetes

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Susilawati R (2018)

     Excerpt This study aimed to find out the potential of ethanol extract in rambutan seed to reduce the risk factors of cardiovascular disease by using animal model on diabetes-type 2 (DM-2). The diabetes mellitus induction type 2 to the animal model was performed through the administration of high fat diet for 4 weeks followed by the daily dosage of Streptozotocin (STZ) 40 mg/kgbw & it was repeated for 4 times in the last week of induction.

   • According to Author (2019)

     Excerpt Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia due to abnormalities of the metabolism of carbohydrates, fats, & proteins. This research is experimental research aims to produce syrup for the treatment of diabetes with various concentrations of propylene glycol as a cosolvent.

   • According to Akika M (2013)

     Excerpt Diabetes Mellitus adalah kelompok penyakit metabolik dengan karakteristik hiperglikemik yang terjadi karena kelainan sekresi insulin, kerja insulin, atau kedua-duanya. Salah satu bahan tradisional yang digunakan secara empiris dalam pengelolaan diabetes adalah biji rambutan (Nephelium lappaceum L.), yang mengandung polifenol & saponin yang berefek hipoglikemik dan sebagai antioksidan.

   • According to Suhendi A (2015)

     Excerpt Group I (negative control) were given a solution of 0.5% CMC-Na, group II (positive control antidiabetic) was given Glibenclamide 0.45 mg/kg, III, IV, & V were given ethanol extract of NL peel with successive doses of 500, 250, & 125 mg/kgBW. The results showed that the ethanol extract of NL fruit peel with dose of 125, 250, & 500 mg/kgBW had blood glucose lowering activity in mice induced alloxan, the percentage decrease in blood glucose levels at 22.65 ± 2.10%, 49.05 ± 3.22%, 61.76 ± 4.26%.

   • According to Soeng S (2015)

     Excerpt this research was done to measure the antioxidants and hypoglycemic activities of Nephelium lappaceum L.

3. 3

   Type II diabetes mellitus: conventional formulation

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2019)

     Excerpt Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia due to abnormalities of the metabolism of carbohydrates, fats, & proteins. Based on the research formulation of the rambutan leaf extract in the preparation of syrup showed that the addition of propylene glycol has an influence on the sense of providing a sweet taste so the addition of propylene glycol to improve the taste of the preparation of syrup NL leaf extract as well.

   • According to Pratiwi E (2020)

     Excerpt Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia due to the abnormal metabolism of carbohydrates, fats, & proteins. Based on the research on rambutan leaf extract formulation on syrup preparations showed that the addition of propylene glycol has an effect on taste which is giving a sweet taste so that the addition of propylene glycol can improve the taste in the preparation of rambutan leaf extract syrup.

   • According to Akika M (2013)

     Excerpt Diabetes Mellitus adalah kelompok penyakit metabolik dengan karakteristik hiperglikemik yang terjadi karena kelainan sekresi insulin, kerja insulin, atau kedua-duanya. Salah satu bahan tradisional yang digunakan secara empiris dalam pengelolaan diabetes adalah biji rambutan (Nephelium lappaceum L.), yang mengandung polifenol & saponin yang berefek hipoglikemik dan sebagai antioksidan.

   • According to Suhendi A (2015)

     Excerpt Group I (negative control) were given a solution of 0.5% CMC-Na, group II (positive control antidiabetic) was given Glibenclamide 0.45 mg/kg, III, IV, & V were given ethanol extract of NL peel with successive doses of 500, 250, & 125 mg/kgBW. The results showed that the ethanol extract of NL fruit peel with dose of 125, 250, & 500 mg/kgBW had blood glucose lowering activity in mice induced alloxan, the percentage decrease in blood glucose levels at 22.65 ± 2.10%, 49.05 ± 3.22%, 61.76 ± 4.26%.

   • According to Soeng S (2015)

     Excerpt this research was done to measure the antioxidants and hypoglycemic activities of Nephelium lappaceum L.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.