Neurolaena lobata (Fèy-pik) : medicinal properties in alcoholic extraction

Neurolaena lobata (Fèy-pik, Zèb-a-pik, Feuille-à-pique, Herbe-à-pique) — family Astéracées.

Scientific synonyms : Calea Lobata-(L)-Sw, Conyza lobata-L, C. Symphiyifolia-Mills, Pluchea symphitifolia-(Mills)-G.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 31 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nayak BS (2014)

     Excerpt The leaves of the Neurolaena lobata (Asteraceae) plant are used to control diabetes and Heal wounds and infections. lobata leaf was evaluated for its ability to Heal inflicted wounds in rats using the excision wound model.

   • According to GUPTA MP (1984)

     Excerpt Lobata in normo & hyperglycemic mice, utilizing the more sensitive enzymatic method for the quantitative determination of blood glucose levels. (1973-4), using 0-toluidine method for glucose determination did show slight hypoglycemic activity.

2. 2

   Cancer: Chemoprevention of (metastatic) lymphoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lajter Ió (2014)

     Excerpt Five new sesquiterpenes, Neurolobatin A (1), Neurolobatin B (2), 5β-hydroxy-8β-isovaleroyloxy-9α-hydroxycalyculatolide (3), 3-epi-desacetylisovaleroylheliangine (4), & 3β-acetoxy-8β-isovaleroyloxyreynosin (5), were isolated from the aerial parts of Neurolaena lobata. The isolated compounds (1-5) were shown to have noteworthy antiproliferative activities against human tumor cell lines (A2780, A431, HeLa, & MCF7).

   • According to KISS I (2015)

     Excerpt An apolar extract of the traditional medicinal plant Neurolaena lobata inhibited the expression of the NPM/ALK chimera, which is causal for the majority of anaplastic large cell lymphomas (ALCLs). This property also inhibits tumour cell intravasation into the lymphatic system & may provide an option to manage this early step of metastatic progression.

3. 3

   Ulcer

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Gracioso JS (2000)

     Excerpt lobata aerial parts were investigated for their ability to prevent ulceration of the gastric mucosa. lobata present a significant anti-ulcer effect when assessed in these ulcer-induced models.

   • According to Walshe-Roussel B (2013)

     Excerpt lobata by the Q'eqchi' Maya of Belize for a variety of inflammatory symptoms and to evaluate the in vitro anti-inflammatory activity of leaf extract and isolated sesquiterpene lactones. The widespread use of Neurolaena lobata (L.) R.

   • According to Lajter Ió (2014)

     Excerpt Five new sesquiterpenes, Neurolobatin A (1), Neurolobatin B (2), 5β-hydroxy-8β-isovaleroyloxy-9α-hydroxycalyculatolide (3), 3-epi-desacetylisovaleroylheliangine (4), & 3β-acetoxy-8β-isovaleroyloxyreynosin (5), were isolated from the aerial parts of Neurolaena lobata. The anti-inflammatory effects of 1-5, evaluated in vitro using LPS- & TNF-α-induced IL-8 expression inhibitory assays, revealed that all these compounds strongly down-regulated the LPS-induced production of IL-8 protein, with Neurolobatin B (2) & 3-epi-desacetyl-sovaleroyl-heliangine (4) being the most effective.

   • According to Passreiter CM (1997)

     Excerpt Passreiter CM et al, Antifeedant bioactivity of sesquiterpene lactones from Neurolaena lobata & their antagonism by γ-amino-butyric acid.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.