Pereskia grandifolia (Wôz-Kaktis) : medicinal properties in alcoholic extraction

Pereskia grandifolia (Wôz-Kaktis, Rose-cactus) — family Cactacées.

Scientific synonyms : Cactus grandifolius-L, C rosa-V, Pereskia ochnocarpa-FAC W, P tampucarpa-FAC, Rhodocactus tampicanus-(FAC)-Backeb.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 27 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Liver disorders associated with metabolic syndrome (MAFLD): abnormal serum levels of ALT, ASP and AST

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to De Almeida M.E.F (2016)

     Excerpt There was no significant difference in total lipids & moisture level between the groups; however, rats fed PGF diet had lower hepatic lipids levels than control group and reduced liver weight. Several measurements were performed including body weight, food consumption, body mass index, Lee index, liver weight, liver & body moisture content, & body & hepatic lipid level.

   • According to Albuquerque E (2023)

     Excerpt Metabolic-associated fatty liver disease (MAFLD) is a complex condition characterized by steatosis & metabolic disturbances. The MAFLD model induced liver abnormalities, including increased AST, ALT, disrupted lipid profile, oxidative stress, & significant hepatic damage.

   • According to Kazama CC (2012)

     Excerpt The oral administration of the HEPG (30mg/kg) significantly reduced serum levels of vasopressin & the mean arterial pressure (MAP) in normotensive rats. Pereskia grandifolia Haw.

   • According to Souza LF (2016)

     Excerpt Pereskia aculeata & Pereskia grandifolia have been studied widely due to their high nutritional & therapeutic values. The results obtained from the germination of P.A & PG can be described by the Weindull distribution model with three parameters, as proposed by Carneiro & Guedes (1992).

2. 2

   Cancer: adjuvant treatment for hepatocellular carcinoma and chronic myeloid leukaemia

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to De Almeida M.E.F (2016)

     Excerpt There was no significant difference in total lipids & moisture level between the groups; however, rats fed PGF diet had lower hepatic lipids levels than control group and reduced liver weight. Several measurements were performed including body weight, food consumption, body mass index, Lee index, liver weight, liver & body moisture content, & body & hepatic lipid level.

   • According to Massocatto AM (2022)

     Excerpt All extracts exhibited selective antiproliferative activity against human chronic myeloid leukemia cell lines (K562). The cytotoxic activity was assessed by an Artemia salina lethality test & the antiproliferative properties against seven human carcinoma cell lines.

   • According to ABDEL-WAHAB SK (2013)

     Excerpt ABDEL-WAHAB SK et al, Anticancer, antioxidant & antibacterial activities of different extracts of Pereskia grandifolia Haw.

   • According to Albuquerque E (2023)

     Excerpt Pereskia grandifolia has shown potential as an alternative treatment, but its effectiveness against liver disease remains unexplored. The MAFLD model induced liver abnormalities, including increased AST, ALT, disrupted lipid profile, oxidative stress, & significant hepatic damage.

   • According to MATUSZEWSKA A (2021)

     Excerpt The present study demonstrated that the low molecular weight subfractions III exhibited the strongest inhibitory activity towards breast carcinoma cells MDA-MB-231, prostatic carcinoma cells PC3, & breast cancer cells MCF7 with the half-maximal inhibitory concentration (IC 50) value of 52,25 μg/mL, 60,66 μg/mL, & 54,92 μg/mL, respectively. the aim of this study is to investigate in vitro the anticancer, antioxidant, & antibacterial activities of three low molecular weight subfractions I, II & III isolated from secondary metabolites produced by the wood degrading fungus Cerrena unicolor.

3. 3

   Hypertension, vasoconstriction, oedema

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2020)

     Excerpt Mucilages, polyethylamnies, flavonol glycosides, betalains & some uncommon triterpenoids have been related to the improvement of human health against general inflammation, metabolic disorders & disturbances of the digestive system. Several genera of the Cactoideae & Pereskioideae subfamilies (Hylocereus, Cereus, Pilosocereus, Stenocereus, Myrtillocactus, Melocactus & Pereskia genera) are often consumed as fresh fruits, processed foods & as functional plants.

   • According to Kazama CC (2012)

     Excerpt The aim of this work is to evaluate the diuretic & hypotensive activities of the infusion (INFPG) & the ethanol extract (HEPG) of PG & possible mechanism of action. The oral administration of the HEPG (30mg/kg) significantly reduced serum levels of vasopressin & the mean arterial pressure (MAP) in normotensive rats.

   • According to Albuquerque E (2023)

     Excerpt Pereskia grandifolia has shown potential as an alternative treatment, but its effectiveness against liver disease remains unexplored. Blood samples were collected to measure cholesterol, triglycerides, glucose, ALT, & AST levels.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.