Periplaneta americana (Ravèt) : medicinal properties in alcoholic extraction

Periplaneta americana (Ravèt, American cockroach, Cockroach, Blatte américaine, Caffard) — family Blattidés.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 107 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Diabetic foot: traditional Chinese formula (Kan-Fu-Xin)

   Plant part used: Whole body.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pang L (2022)

     Excerpt Along with the increasing attempts to explore the wound healing effective substances of Periplaneta americana (L.) (PA), a medicinal insect in traditional Chinese medicine, researchers' attention turned to the endogenetic macromolecules, such as polysaccharides & peptides. Based on the remarkable anti-inflammatory effects of PAGPs on LPS-induced RAW264.7 cells, the topical administration of PAGP-1 & PAGP-2 could significantly accelerate full-thickness wound healing in diabetic mice, involving to alleviate the inflammation, increase the ratio of type I & type III collagen fibers, & promote the polarization of macrophages M1 to M2.

   • According to LIAO Q (2022)

     Excerpt Periplaneta americana, a type of animal medicine, has been widely used for wound healing in clinical settings. Finally, as proof of concept, PaPPc2 & PaPPc3 were employed to accelerate the acute wounds of diabetic mice, involving in increase blood vessels & the amounts of angiogenesis-related cytokines (α-SMA, VEGF, & CD31).

   • According to Li Q (2022)

     Excerpt Over the past few years, SXYH has been applied in the Affiliated Hospital of Chengdu University of TCM (Chengdu, China) for the treatment of diabetic foot infections & bedsores, whereas there has been rare research on the effect of SXYH ointment on wound healing. In this study, SXYH ointment was first applied to streptozotocin (STZ)-triggered diabetic ICR mice (4–6 weeks, 20 ± 2 g) to observe the accelerated wound healing & the shortened wound healing period.

   • According to Zhao Y (2017)

     Excerpt As a kind of TCM, Periplaneta americana has a good effect on clinical application, & its anti-tumor effects has been increasingly well studied. A growing attention has been paid to anti-cancer effects of traditional Chinese medicine (TCM) with low toxicity & good efficacy.

   • According to Zeng C (2019)

     Excerpt The purpose of this review is to elaborate the role ofPeriplaneta americana in modern & traditional Chinese medicine (TCM) a&compare the use of the species in these two forms of medical treatments. The development of extraction technology in modern Chinese medicine has revealed that many extracts from PA are able to play an important role in the control of diseases such as cancer.

2. 2

   Liver degeneration

   Plant part used: Whole body.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Zhou Y (2020)

     Excerpt The traditional Chinese medicines known as Periplaneta americana extracts (PAEs) positively influence wound healing by promoting tissue repair. We used a mouse liver regeneration model after 70% partial hepatectomy (PH) & a hepatocyte culture to determine whether PAEs can promote liver regeneration as effectively as skin regeneration & establish their modes of action. (2018) — excerpt: The aims of this study were to examine the anti-fibrotic effects of extracts of Periplaneta americana (EPA) on CCl4-induced hepatic fibrosis in rats, to preliminary determine the anti-fibrotic efficacy of EPA, & to identify a potential & effective therapeutic agent to attenuate hepatic fibrosis. The mechanism of EPA action may be related to the inhibition of TGF-β1, NF-κB, & α-SMA expressions and the reduction of TIMP-1 levels in the liver to reduce the accumulation of extracellular matrix (ECM) components, thereby blocking the relevant signaling pathways & preventing inflammatory responses to attenuate or reverse hepatic fibrosis.

   • According to LYU H (2019)

     Excerpt To investigate anti-tumor effects of Periplaneta americana polypeptide PAP-2 on H22 tumor-bearing mice. The tumor inhibition rate （38.95％ of PAP-2 high dose group was significantly higher than those of skimmed cream group & CⅡ-3 group P＜0.05）which was close to that （40.87％ of 5-FU group （P＞0.05, Spleenindex thymus index & liver index of mice in PAP-2 high dose group were significantly those of model group and CⅡ-3 group （P＜0.05 & the liver index of mice in PAP-2 high dose group was significantly higher than that of skimmed cream group （P＜0.05）.

   • According to Fang LL (2007)

     Excerpt Observe the effect of extractive from Periplaneta americana(CⅡ-3) on immune & on inhibitory tumor action in S180-bearing mice.Method: S180 sarcoma was implanted into right-fore oxter,then randomly divided into normal group, model group, cyclophosphamide group(30 mg·kg-1,ip quaque die alterna),CⅡ-3 high dosage group,medium dosage group & low dosage group (200,100,50 mg·kg-1,ig),t he S180-bearing mice in every group were received corresponding treatment for 10 days.Tumor growth of the mice was observed, immune organs were weighted to calculate the organ index & ELISA was used to test the concentration of vascular tumor necrosis factor-α(TNF-α) in serum.Results: CⅡ-3 inhibited the growth of S180 sarcoma significantly,200,100,50 mg·kg-1 dosages inhibited the tumor weight by 58.22%, 45.66%, 35.37% .CⅡ-3 had protective function on immune,the liver indexs in high dosage group, medium dosage group & low dosage group were 53.54,54.15 59.53 mg·g-1 respectively, spleen indexs were 3.60,4.44,5.18 mg·g-1 respectively & thymic indexs were 2.45,2.00,2.30 mg·g-1 respectively.And it dramatically increased the concentration of TNF-α in serum, the concentrations of TNF-α of three groups were 324.92, 304.

   • According to Liang G (2016)

     Excerpt Liang G et al, the inhibitory effect of Periplaneta americana polypeptide on tumor growth & angiogenesis in nude mice bearing human hepatocellular carcinoma Bel-7402 cells.

3. 3

   Cancer: adjuvant treatment of gastric carcinoma, nasopharyngeal carcinoma, oral squamous cell carcinoma, chronic myeloid leukaemia and promyelocytic leukaemia, non-small-cell lung cancer, oesophageal cancer and prostate cancer

   Plant part used: Whole body.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to NI L (2020)

     Excerpt to investigate the effects of Periplaneta americanaextract on the proliferation & apoptosis of human non-small cell lung cancer A 549 cells as well as its possible mechanism. The percentage of cells in the early stage of apoptosis the late stage of apoptosis the late stage of apoptosis and the early stage of necrosis the late stage of necrosis except for the percentage of cells in the late stage of apoptosis and early stage of necrosis when treated with YS-F 27 μg/mL for 72 h，the percentage of cells in the late stage of necrosis when treated with YS-F 3，9 μg/mL for 72 h were decreased significantly & the percentage of cells in S phase （except for YS-F 3 μg/mL for 72 h）& Sub-G 0/G1 phase after treated for 72 h were significantly higher than same group after 48 h of treatment while the percentage of cells in G 0/G1 & G 2/M phase were significantly lower than same group after 48 h of treatment （P＜0.01; After treated with YS-F 9，27，81 μg/mL for 48 h，the reduction rate of cell mitochondrial membrane potential was increased significantly ；YS-F 27, 81 μg/mL groups were significantly higher than YS-F 9 μg/mL group & YS-F 81 μg/mL group was significantly higher than YS-F 27 μg/mL group.

   • According to Zhao Y (2017)

     Excerpt As a kind of TCM, Periplaneta americana has a good effect on clinical application, & its anti-tumor effects has been increasingly well studied. The main mechanisms of its anti-tumor effects include suppression of tumor cell growth, induction of cell cycle arrest & tumor cell apoptosis, inhibition of angiogenesis, enhancement of immunity, & reversal of tumor drug resistance.

   • According to Ali SM (2017)

     Excerpt Here, we characterized antibacterial properties in extracts of various body organs of Periplaneta americana & showed potent antibacterial activity in crude brain extract against methicillin-resistant Staphylococcus aureus & neuropathogenic Escherichia coli K1. Among hundreds of compounds, only a few homologous compounds were identified that contained the isoquinoline group, chromene derivatives, thiazine groups, imidazoles, pyrrole-containing analogs, sulfonamides, furanones, & flavanones & known to possess broad-spectrum antimicrobial properties & anti-inflammatory, anti-tumour, & analgesic properties.

   • According to Jiang Y (2006)

     Excerpt Jiang Y et al, Inhibitory effect & mechanism research of Periplaneta americana extract on 3LL lung cancer cell in mice.

   • According to Author (2014)

     Excerpt To explore the effect of Periplaneta americana extract on human lung cancer cell H125 & its mechanism.Methods The human lung cancer cells H125 were divided into negative control group,positive control group(cisplatin 10μg/mL) & PA extract group(10,20,40 μg/mL).Methyl thiazolyl tetrazolium(MTT) colorimetric method was adopted to observe the growth of H125 cells.Cell cycle,apoptosis & mitochondrial membrane potential were measured with flow cytometry.The expression of Bax and Bcl-2 protein were detected with Western blot.Results PA extract could inhibit the growth of human lung cancer cell H125,with a 50% inhihition concentration(IC50) of 24.8 μg/ml. Conclusion : PA extract can inhibit the growth of human lung cancer cell H125,arrest the cell cycle in S phase,and induce apoptosis through.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.