Pfaffia spreng (Stronger than man) : medicinal properties in alcoholic extraction

Pfaffia spreng (Stronger than man, Plus-fort-que-l ’homme) — family Amaranthacées.

Scientific synonyms : Alternanthera iresinoides-Kunth in HBK, Iresine luzuliflora-Griseb, Pfaffia glomerata-(Spreng)-Pedersen.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 55 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Oedema, rheumatism, osteoarthritis

   Plant part used: Root – drying: circulating air at 40° / 36 hours.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Neto AG (2005)

     Excerpt The anti-inflammatory & antinociceptive effects of the crude hydroalcoholic extract (PE) of Pfaffia glomerata roots was assessed in the carrageenan-induced rat paw edema at the doses of 100, 200 & 300 mg/kg, using different animal models. An anti-inflammatory dose effect response correlation of r=0.997 & Y=11.67x+0.02 was found.

   • According to Teixeira CG (2006)

     Excerpt Pfaffia glomerata is used in southern American countries against inflammatory diseases. Further, its anti-oedematogenic action against carrageenan was prevented fully by N(G) nitro-L-arginine-methyl-ester (10 mg kg(-1), s.c.), as well as by methylene blue (20 mg kg(-1), s.c.) or 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (2 mg kg(-1), s.c.).

   • According to Costa CA (2018)

     Excerpt Conclusion: Intestinal anti-inflammatory activity of PP was related to modulation of Mapk & mucin gene expression, as well as mucus secretion in intestinal inflammation,. to evaluate intestinal anti-inflammatory effects of P.

   • According to Taniguchi SF (1997)

     Excerpt Antiinflammatory activities of aqueous & saponin extracts & ecdysterone obtained from Pfaffia iresinoides were studied by using three experimental inflammatory models in rats. The saponin extract (25 & 50mg/kg, p.o.) reduced the leukocyte migration, particularly of mononuclear cells in the carrageenin-inducedpleurisy.

   • According to Matta AL (2012)

     Excerpt Pfaffia glomerata is a species commonly used as a sexual stimulant, tranquilizer, anti-inflammatory & healing effects.

2. 2

   Gastric ulcer

   Plant part used: Root – drying: circulating air at 40° / 36 hours.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Freitas CS (2003)

     Excerpt Female Wistar rats were pretreated orally (p.o.) with the hydroalcoholic extract of Pfaffia (0.5, 1 and 2 g.kg-1) before the induction of ulcer with hypothermic restraint stress (HRS), ethanol (ET) or indomethacin (IND). The hydroalcoholic extract of Pfaffia (0.5, 1 & 2 mg.kg-1) protected rats against HRS and ET - induced ulcers, but was not able to protect the gastric mucosa against IND - induced ulcers.

   • According to Freitas CS (2004)

     Excerpt Freitas CS et al, Involvement of nitric oxide in the gastroprotective effects of an aqueous extract of Pfaffia glomerata (Spreng.) Pedersen, Amaranthaceae, in rats.

   • According to Freitas CS (2004)

     Excerpt Involvement of nitric oxide in the gastroprotective effects of an aqueous extract of Pfaffia glomerata (Spreng.) Pedersen, Amaranthaceae, in rats.

3. 3

   Psychological disorders: anxiety, nervousness, convulsions

   Plant part used: Root – drying: circulating air at 40° / 36 hours.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2000)

     Excerpt The alcoholic extract of Pfaffia glomerata roots (100, 500, 1000 mg/kg, intraperitoneally (i.p.), and 500, 1000, 1500 mg/kg, per os) was studied in several behavioral animal models for the evaluation of central activity: open field, barbiturate sleeping time, pentilenotetrazole (PTZ)-induced convulsions, elevated plus-maze, step-down inhibitory avoidance & forced swimming test. glomerata roots presents different effects depending on the route of administration: by i.p route, it seems to be a central nervous system depressant agent; by oral route, it seems to be ineffective, at least in the tested dose,.

   • According to Oliveira da Silva TF (2021)

     Excerpt The quantification of β-ecdysone by Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC–MS/MS) revealed that the highest accumulation of metabolites occurred after 8 weeks in the roller bottle culture system, wherein 1.81 μg of β-ecdysone was recovered from 30 mg of dry root. β-ecdysone is the main compound of commercial interest produced by the roots of Pfaffia glomerata & is used in herbal medicines & dietary supplements.

   • According to Costa CA (2015)

     Excerpt Clinical studies suggest that the initiation of IBD is multifactorial, involving genetics, the immune system & environmental factors, such as diet, drugs & stress. Pfaffia paniculata is an adaptogenic medicinal plant used in Brazilian folk medicine as an “anti-stress” agent.

   • According to De Paris F (n.d.)

     Excerpt De Paris F et al, Análise cromatográfica e atividade depressora central de produtos végétais comercializados como Pfaffia paniculata Mart.

   • According to FENNER R (2001)

     Excerpt Efeito depressor do Sistema Nervoso Central (SNC) do extrato orgânico de Pfaffia glomerata Spreng (Amaranthaceae).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.