Phoenix dactylifera (Date palm) : medicinal properties in alcoholic extraction

Phoenix dactylifera (Date palm, Palmié-Datié, Palmier-dattier) — family Arecacées.

Scientific synonyms : Phoenix cycadifolia hort., Attens ex Regel.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 229 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of carcinoma: hepatocellular, oral squamous cell, and triple-negative breast

   Plant part used: Fruit (flesh).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to AbouZeid AS (2024)

     Excerpt immunomodulatory, antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, anti-mutagenic & anti-cancer activities, in addition to its positive effects on male & female fertility. Phoenix dactylifera L.

   • According to Ibrahim AS (2024)

     Excerpt immunomodulatory, antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, anti-mutagenic & anti-cancer activities, in addition to its positive effects on male & female fertility. Phoenix dactylifera L.

   • According to Khan F (2017)

     Excerpt Many natural products including ajwa dates (Phoenix dactylifera L.), are claimed to have hepatoprotective & HCC inhibitory effects, but most lack scientific validation. Hepatocellular carcinoma (HCC) accounts for major cancer-related deaths despite current advanced therapies.

   • According to Zubair Alam M (2023)

     Excerpt Ajwa, a variety of date palm Phoenix dactylifera L., produces the most expensive date fruits.

   • According to Zhang C (2013)

     Excerpt Ajwa, a variety of date palm Phoenix dactylifera L., produces the most expensive date fruits.

2. 2

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Anbar SH (2024)

     Excerpt Diabetes mellitus was induced by a single intraperitoneal injection of Streptozotocin (40mg/kg). A significant reduction in blood sugar in diabetic rats & wound diameter in the treated group compared to the control group in both diabetic & normal rats was observed, confirming the promising role of palm leaf extract on diabetes & wound care.

   • According to Chakroun M (2016)

     Excerpt The oral administration of HEPdL (20mg/kg) in alloxan-induced diabetic mices for 28 days showed a more significant anti-diabetic activity than that of the drug (50mg/kg). This study was designed to evaluate the effectiveness of hydroalcoholic extract of Phoenix dactylifera L.

   • According to Zain MRAM (2022)

     Excerpt In this article, we review the most recent research on the role of date palm (Phoenix dactylifera L.) fruits (DPFs) to prevent or treat COVID-19 infection. The mechanisms underlying this preventive or therapeutic effect are also discussed in terms of bioactivity potentials in date palm, e.g., antimicrobial, antioxidant, anticancer, anti-diabetic, anti-inflammatory, neuroprotective, & hemolytic potential, as well as prospect against COVID-19 disease & the potential product development.

   • According to Hinkaew J (2021)

     Excerpt Date palm fruit (Phoenix dactylifera L.) is commonly consumed around the world & has recently become an economical crop in Eastern Thailand, especially the Barhi cultivar that can be consumed as fresh fruit. Effects of different planting origins (cell culture origin (CO) & seed origin (SO)) of PD fruits at the Khalal stage of Barhi cultivar were investigated for nutritive values, bioactive compounds, & in vitro health-promoting properties via key enzyme inhibitions against obesity (lipase), diabetes (α-amylase, α-glucosidase, & dipeptidyl peptidase-IV), Alzheimer’s disease (cholinesterases and β-secretase), & hypertension (angiotensin-converting enzyme).

   • According to Esfandiari E (2020)

     Excerpt Esfandiari E et al, Protective & therapeutic effects of Phoenix dactylifera leaf extract on pancreatic β-cells & diabetic parameters in streptozotocin-induced diabetic rats.

3. 3

   Gastric ulcer

   Plant part used: Fruit (flesh).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Al-Qarawi AA (2005)

     Excerpt On the last day of treatment, rats were fasted for 24 h, & were then given ethanol, 80% (1 ml/rat) by gastric intubation to induce gastric ulcer. The results indicated that the aqueous & ethanolic extracts of the date fruit &, to a lesser extent, date pits, were effective in ameliorating the severity of gastric ulceration and mitigating the ethanol-induced increase in histamine & gastrin concentrations, & the decrease in mucin gastric levels.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.