Phragmites australis (Ti-wozo) : medicinal properties in alcoholic extraction

Phragmites australis (Ti-wozo, Little reed, Petit roseau) — family Poacées.

Scientific synonyms : Phragmites australis var. berlandieri (Fourn.) C.F. Reed P communis Trin., PC var. berlandieri (Fourn.) Fern., PC ssp. Berlandieri (Fourn.) A.& D. Löve, P phragmites (L.) Karst..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 29 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of carcinoma: colorectal, liver and breast

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • Excerpt (2022) — excerpt: The purpose of this study was to construct Phragmites rhizoma polysaccharide-based nano-drug delivery systems (PRP2-SeNPs-H/Aza-Lips) for synergistically alleviating ulcerative colitis & to investigate the important roles of Phragmites rhizoma polysaccharide-based nanocarriers in PRP2-SeNPs-H/Aza-Lips. PA rhizoma polysaccharide-based nanocarriers may protect azathioprine liposomes against gastrointestinal digestion, enhance the therapeutic effects on ulcerative colitis, & significantly reduce liver damage from azathioprine, which helps to improve the efficacy & toxicity of clinical drugs,.

   • According to ABDULLA SA (2025)

     Excerpt The cytotoxic effects of the extracts on the breast (MCF-7), hepatocellular (Hep-G2), & colon (Caco-2) cancer cell lines were assessed using the 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay. Aim: This study analyzed & identified phytochemical compounds & the antioxidant, cytotoxic, antimicrobial, & antiviral activities of Phragmites australis ethanolic extract (PAEE).

   • According to Chen Y (2022)

     Excerpt Two new alkaloids, phranisines A–B (1–2), along with two known compounds, N-p-Coumaroyl serotonin (3) and N-p-coumaroyl-tryptamine (4), were isolated from the roots of Phragmites australis. All the isolated compounds were tested for their cytotoxic activities against HeLa & MCF-7 human cancer cell lines, & compounds 2–4 showed moderate cytotoxic activities against HeLa cell lines with IC50 values ranging from 13.2 to 18.6 μM.

   • According to Zhu L (2017)

     Excerpt Phragmites australis, a worldwide distributed wetland grass, is traditionally used as foodmaking helper & spice in China. Here, we demonstrated that lipopolysaccharide (LPS)-induced production of inflammatory mediators nitric oxide (NO) & reactive oxygen species (ROS), & the pro-inflammatory cytokines tumor necrosis factor-a (TNF-a) & interleukin-1β (IL-1β) in RAW264.7 macrophage were significantly inhibited by the crude extract.

2. 2

   Bacterial infection: Pseudomonas aeruginosa

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Delfino V (2021)

     Excerpt In this context, bacteria associated to medicinal plants, including Phragmites australis, might represent an important source of antimicrobial compounds. Materials & methods: In the present work, 21 bacterial endophytes isolated from PA roots were tested, by cross-streaking, for their inhibitory activity against 36 multidrug-resistant pathogens isolated from food, clinical patients & hospitals.

   • According to Zhu L (2017)

     Excerpt Phragmites australis, a worldwide distributed wetland grass, is traditionally used as foodmaking helper & spice in China. australisa a novel natural herb as a potential candidate for the generation of antiviral & anti-inflammatory agent.

   • According to Sohaib M (2022)

     Excerpt The antimicrobial activity assays were performed on gram-positive bacteria (i.e., Bacillus subtilis & Staphylococcus aureus), gram-negative bacteria (i.e., Escherichia coli, & Pseudomonas aeruginosa), & fungi (i.e., Aspergillus niger, Candida albicans, & Rhizopus spp.). marina ‘s shoots), with non-mangrove plants, i.e., Phragmites australis (5E: PA ‘s shoot), & Moringa oleifera (6E: MO ‘s leaves) for their antimicrobial activities, total phenolic contents, antioxidant activity, & cytotoxicity potential.

   • According to ABDULLA SA (2025)

     Excerpt Aim: This study analyzed & identified phytochemical compounds & the antioxidant, cytotoxic, antimicrobial, & antiviral activities of Phragmites australis ethanolic extract (PAEE). Antimicrobial effects were tested against four bacterial strains & three fungi, & the antiviral activities of the extracts against herpes simplex virus type 1 (HSV-1) & hepatitis A virus (HAV) were assessed.

   • According to Kim NS (2019)

     Excerpt A rhizome of Phragmites communis Trinius has been used in traditional medicine to remove a heat, relieve vomiting & fever, nourish body fluids, & treat diseases like cancers. Materials & methods: The genotoxic potential of AEPR was evaluated using both in vitro & in vivo assay systems: a bacterial reverse mutation (AMES) test using auxotrophic mutant strains of Salmonella typhimurium (TA100, TA1535, TA98, TA1537) & Escherichia coli (WP2 uvrA), a chromosomal aberration test using Chinese hamster lung cells, & a micronucleus test using bone marrow cells from male ICR mice subjected to an oral administration of AEPR.

3. 3

   Fungal infection: Candida albicans, Aspergillus niger

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Delfino V (2021)

     Excerpt In this context, bacteria associated to medicinal plants, including Phragmites australis, might represent an important source of antimicrobial compounds.

   • According to Zhu L (2017)

     Excerpt Phragmites australis, a worldwide distributed wetland grass, is traditionally used as foodmaking helper & spice in China. australisa a novel natural herb as a potential candidate for the generation of antiviral & anti-inflammatory agent.

   • According to Sohaib M (2022)

     Excerpt The antimicrobial activity assays were performed on gram-positive bacteria (i.e., Bacillus subtilis & Staphylococcus aureus), gram-negative bacteria (i.e., Escherichia coli, & Pseudomonas aeruginosa), & fungi (i.e., Aspergillus niger, Candida albicans, & Rhizopus spp.). marina ‘s shoots), with non-mangrove plants, i.e., Phragmites australis (5E: PA ‘s shoot), & Moringa oleifera (6E: MO ‘s leaves) for their antimicrobial activities, total phenolic contents, antioxidant activity, & cytotoxicity potential.

   • According to ABDULLA SA (2025)

     Excerpt Aim: This study analyzed & identified phytochemical compounds & the antioxidant, cytotoxic, antimicrobial, & antiviral activities of Phragmites australis ethanolic extract (PAEE). Antimicrobial effects were tested against four bacterial strains & three fungi, & the antiviral activities of the extracts against herpes simplex virus type 1 (HSV-1) & hepatitis A virus (HAV) were assessed.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.